| 1 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,700,000 |
3,298,000 |
14.36% |
|
|
| 2 |
Abingworth LLP |
1,600,000 |
3,072,000 |
13.38% |
|
|
| 3 |
Lombard Odier Asset Management (USA) Corp |
1,098,198 |
2,131,000 |
9.28% |
|
|
| 4 |
Versant Venture Management, LLC |
1,048,601 |
2,034,285 |
8.86% |
|
|
| 5 |
Point72 Asset Management, L.P. |
1,035,288 |
2,008,000 |
8.75% |
|
|
| 6 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
950,000 |
1,843,000 |
8.03% |
|
|
| 7 |
ARMISTICE CAPITAL, LLC |
836,000 |
1,622,000 |
7.06% |
|
|
| 8 |
Omega Fund Management, LLC |
650,000 |
1,261,000 |
5.49% |
|
|
| 9 |
VANGUARD GROUP INC |
427,907 |
830,000 |
3.62% |
|
|
| 10 |
Ghost Tree Capital, LLC |
400,000 |
776,000 |
3.38% |
|
|
| 11 |
J. Goldman & Co LP |
359,500 |
697,000 |
3.04% |
|
|
| 12 |
Visium Asset Management, LP |
321,158 |
623,000 |
2.71% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
293,294 |
569,000 |
2.48% |
|
|
| 14 |
Iguana Healthcare Management, LLC |
250,000 |
485,000 |
2.11% |
|
|
| 15 |
ALLIANCEBERNSTEIN L.P. |
234,974 |
456,000 |
1.99% |
|
|
| 16 |
PURA VIDA INVESTMENTS, LLC |
200,000 |
388,000 |
1.69% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
85,796 |
166,000 |
0.72% |
|
|
| 18 |
BNP PARIBAS FINANCIAL MARKETS |
55,000 |
106,700 |
0.46% |
|
|
| 19 |
BlackRock Fund Advisors |
52,014 |
101,000 |
0.44% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
46,238 |
90,000 |
0.39% |
|
|
| 21 |
Bank of New York Mellon Corp |
29,875 |
58,000 |
0.25% |
|
|
| 22 |
NORTHERN TRUST CORP |
30,116 |
58,000 |
0.25% |
|
|
| 23 |
Parallax Volatility Advisers, L.P. |
23,400 |
45,000 |
0.20% |
|
|
| 24 |
Virtu KCG Holdings LLC |
22,640 |
44,000 |
0.19% |
|
|
| 25 |
TFS CAPITAL LLC |
21,263 |
41,000 |
0.18% |
|
|
| 26 |
Alpha Cubed Investments, LLC |
20,000 |
31,000 |
0.14% |
|
|
| 27 |
BOOTHBAY FUND MANAGEMENT, LLC |
15,747 |
31,000 |
0.14% |
|
|
| 28 |
BALYASNY ASSET MANAGEMENT L.P. |
12,600 |
24,000 |
0.10% |
|
|
| 29 |
Creative Planning |
12,000 |
23,000 |
0.10% |
|
|
| 30 |
Mariner, LLC |
12,000 |
23,000 |
0.10% |
|
|
| 31 |
Walleye Trading LLC |
4,100 |
8,000 |
0.03% |
|
|
| 32 |
BlackRock Investment Management, LLC |
3,151 |
6,000 |
0.03% |
|
|
| 33 |
MORGAN STANLEY |
2,568 |
5,000 |
0.02% |
|
|
| 34 |
BANK OF AMERICA CORP /DE/ |
2,200 |
4,000 |
0.02% |
|
|
| 35 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
257 |
1,000 |
0.00% |
|
|
