| 1 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,700,000 |
2,873,000 |
15.78% |
|
|
| 2 |
Abingworth LLP |
1,600,000 |
2,672,000 |
14.68% |
|
|
| 3 |
Lombard Odier Asset Management (USA) Corp |
1,085,681 |
1,835,000 |
10.08% |
|
|
| 4 |
Versant Venture Management, LLC |
1,048,601 |
1,772,135 |
9.73% |
|
|
| 5 |
Point72 Asset Management, L.P. |
1,035,288 |
1,750,000 |
9.61% |
|
|
| 6 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
993,920 |
1,680,000 |
9.23% |
|
|
| 7 |
Omega Fund Management, LLC |
650,000 |
1,099,000 |
6.04% |
|
|
| 8 |
SABBY MANAGEMENT, LLC |
593,900 |
1,004,000 |
5.51% |
|
|
| 9 |
VANGUARD GROUP INC |
498,726 |
843,000 |
4.63% |
|
|
| 10 |
J. Goldman & Co LP |
356,260 |
602,000 |
3.31% |
|
|
| 11 |
Visium Asset Management, LP |
321,158 |
543,000 |
2.98% |
|
|
| 12 |
ALLIANCEBERNSTEIN L.P. |
234,974 |
456,000 |
2.50% |
|
|
| 13 |
PURA VIDA INVESTMENTS, LLC |
200,000 |
338,000 |
1.86% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
98,296 |
166,000 |
0.91% |
|
|
| 15 |
RENAISSANCE TECHNOLOGIES LLC |
60,900 |
103,000 |
0.57% |
|
|
| 16 |
BlackRock Fund Advisors |
53,975 |
91,000 |
0.50% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
46,238 |
78,000 |
0.43% |
|
|
| 18 |
NORTHERN TRUST CORP |
30,116 |
51,000 |
0.28% |
|
|
| 19 |
Hoxton Financial, Inc. |
25,920 |
44,000 |
0.24% |
|
|
| 20 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
25,405 |
43,000 |
0.24% |
|
|
| 21 |
Parallax Volatility Advisers, L.P. |
25,274 |
43,000 |
0.24% |
|
|
| 22 |
Bank of New York Mellon Corp |
22,147 |
37,000 |
0.20% |
|
|
| 23 |
Alpha Cubed Investments, LLC |
20,000 |
34,000 |
0.19% |
|
|
| 24 |
Virtu KCG Holdings LLC |
18,946 |
32,000 |
0.18% |
|
|
| 25 |
BlackRock Investment Management, LLC |
3,566 |
6,000 |
0.03% |
|
|
| 26 |
BANK OF AMERICA CORP /DE/ |
2,200 |
4,000 |
0.02% |
|
|
| 27 |
Tower Research Capital LLC (TRC) |
2,473 |
4,000 |
0.02% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
1,562 |
2,000 |
0.01% |
|
|
| 29 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
257 |
0 |
0.00% |
|
|
