| 1 |
Abingworth LLP |
1,600,000 |
2,720,000 |
22.60% |
|
|
| 2 |
Versant Venture Management, LLC |
1,048,601 |
1,814,080 |
15.07% |
|
|
| 3 |
KINGDON CAPITAL MANAGEMENT, L.L.C. |
941,348 |
1,629,000 |
13.54% |
|
|
| 4 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
700,000 |
1,211,000 |
10.06% |
|
|
| 5 |
Lombard Odier Asset Management (USA) Corp |
576,665 |
998,000 |
8.29% |
|
|
| 6 |
VANGUARD GROUP INC |
527,684 |
913,000 |
7.59% |
|
|
| 7 |
J. Goldman & Co LP |
330,207 |
571,000 |
4.74% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
309,268 |
535,000 |
4.45% |
|
|
| 9 |
Omega Fund Management, LLC |
301,477 |
522,000 |
4.34% |
|
|
| 10 |
ALLIANCEBERNSTEIN L.P. |
204,256 |
353,000 |
2.93% |
|
|
| 11 |
RENAISSANCE TECHNOLOGIES LLC |
117,400 |
203,000 |
1.69% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
98,296 |
170,000 |
1.41% |
|
|
| 13 |
BlackRock Fund Advisors |
67,554 |
117,000 |
0.97% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
46,238 |
80,000 |
0.66% |
|
|
| 15 |
NORTHERN TRUST CORP |
31,100 |
54,000 |
0.45% |
|
|
| 16 |
Alpha Cubed Investments, LLC |
20,000 |
35,000 |
0.29% |
|
|
| 17 |
Bank of New York Mellon Corp |
17,204 |
30,000 |
0.25% |
|
|
| 18 |
ARDSLEY ADVISORY PARTNERS LP |
15,210 |
26,000 |
0.22% |
|
|
| 19 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
10,500 |
18,000 |
0.15% |
|
|
| 20 |
UBS Group AG |
7,069 |
12,000 |
0.10% |
|
|
| 21 |
BlackRock Investment Management, LLC |
3,841 |
7,000 |
0.06% |
|
|
| 22 |
Creative Planning |
4,000 |
7,000 |
0.06% |
|
|
| 23 |
MORGAN STANLEY |
2,175 |
4,000 |
0.03% |
|
|
| 24 |
Parallax Volatility Advisers, L.P. |
1,764 |
3,000 |
0.02% |
|
|
| 25 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
1,435 |
2,000 |
0.02% |
|
|
| 26 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
257 |
0 |
0.00% |
|
|
| 27 |
BANK OF AMERICA CORP /DE/ |
1 |
0 |
0.00% |
|
|
