| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,204,768 | 76,195,000 | 10.26% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 5,520,566 | 67,793,000 | 9.13% | ||
| 3 | Broadfin Capital, LLC | 5,088,883 | 62,491,000 | 8.41% | ||
| 4 | Visium Asset Management, LP | 4,290,972 | 52,693,000 | 7.09% | ||
| 5 | STATE STREET CORP | 3,693,725 | 45,355,000 | 6.11% | ||
| 6 | HealthCor Management, L.P. | 3,575,000 | 43,901,000 | 5.91% | ||
| 7 | Murphy Michael R | 2,397,620 | 29,443,000 | 3.96% | ||
| 8 | TimesSquare Capital Management, LLC | 2,174,540 | 26,703,000 | 3.60% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,147,604 | 26,373,000 | 3.55% | ||
| 10 | VANGUARD GROUP INC | 1,763,507 | 21,656,000 | 2.92% | ||
| 11 | TURNER INVESTMENTS LLC | 1,357,418 | 16,669,000 | 2.24% | ||
| 12 | CHARTWELL INVESTMENT PARTNERS, LLC | 1,287,853 | 15,815,000 | 2.13% | ||
| 13 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,200,000 | 14,736,000 | 1.98% | Call | |
| 14 | BANK OF MONTREAL /CAN/ | 1,154,539 | 14,178,000 | 1.91% | ||
| 15 | Point72 Asset Management, L.P. | 934,396 | 11,474,000 | 1.54% | ||
| 16 | ORBIMED ADVISORS LLC | 896,000 | 11,003,000 | 1.48% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 884,100 | 10,857,000 | 1.46% | ||
| 18 | SYSTEMATIC FINANCIAL MANAGEMENT LP | 882,850 | 10,841,000 | 1.46% | ||
| 19 | Allianz Asset Management GmbH | 867,140 | 10,648,000 | 1.43% | ||
| 20 | NEW YORK STATE COMMON RETIREMENT FUND | 768,150 | 9,433,000 | 1.27% | ||
| 21 | NORTHERN TRUST CORP | 708,332 | 8,698,000 | 1.17% | ||
| 22 | EMERALD ADVISERS, LLC | 697,133 | 8,561,000 | 1.15% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 477,400 | 5,862,000 | 0.79% | Call | |
| 24 | BARCLAYS PLC | 471,800 | 5,662,000 | 0.76% | Call | |
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 457,956 | 5,624,000 | 0.76% | ||
| 26 | FRED ALGER MANAGEMENT, LLC | 432,217 | 5,308,000 | 0.71% | ||
| 27 | Ghost Tree Capital, LLC | 425,000 | 5,219,000 | 0.70% | ||
| 28 | Bank of New York Mellon Corp | 420,121 | 5,159,000 | 0.69% | ||
| 29 | Nicholas Investment Partners, LP | 388,739 | 4,774,000 | 0.64% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 360,743 | 4,429,000 | 0.60% | ||
| 31 | COWEN INC. | 353,666 | 4,343,000 | 0.58% | ||
| 32 | MORGAN STANLEY | 340,899 | 4,186,000 | 0.56% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 340,825 | 4,185,000 | 0.56% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 317,166 | 3,895,000 | 0.52% | ||
| 35 | Tygh Capital Management, Inc. | 309,463 | 3,800,000 | 0.51% | ||
| 36 | EverPoint Asset Management, LLC | 304,600 | 3,740,000 | 0.50% | ||
| 37 | TANG CAPITAL MANAGEMENT LLC | 300,000 | 3,684,000 | 0.50% | ||
| 38 | TUDOR INVESTMENT CORP ET AL | 294,814 | 3,620,000 | 0.49% | ||
| 39 | AMERIPRISE FINANCIAL INC | 279,510 | 3,432,000 | 0.46% | ||
| 40 | WASATCH ADVISORS LP | 239,029 | 2,935,000 | 0.40% | ||
| 41 | FORESTERS INVESTMENT MANAGEMENT COMPANY, INC. | 231,000 | 2,837,000 | 0.38% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 221,269 | 2,717,000 | 0.37% | ||
| 43 | Iguana Healthcare Management, LLC | 220,000 | 2,702,000 | 0.36% | ||
| 44 | MARSHALL WACE, LLP | 204,348 | 2,509,000 | 0.34% | ||
| 45 | UBS AG | 182,733 | 2,244,000 | 0.30% | ||
| 46 | STIFEL FINANCIAL CORP | 182,007 | 2,235,000 | 0.30% | ||
| 47 | CITADEL ADVISORS LLC | 178,841 | 2,196,000 | 0.30% | ||
| 48 | A.R.T. Advisors, LLC | 171,196 | 2,102,000 | 0.28% | ||
| 49 | MCKINLEY CAPITAL MANAGEMENT LLC | 167,565 | 2,058,000 | 0.28% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 162,544 | 1,996,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
