| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 12,780,094 | 231,703,000 | 8.59% | ||
| 2 | VANGUARD GROUP INC | 11,888,874 | 215,545,000 | 8.00% | ||
| 3 | BlackRock Fund Advisors | 7,052,901 | 127,869,000 | 4.74% | ||
| 4 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 6,816,903 | 123,590,000 | 4.58% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 6,434,439 | 116,656,000 | 4.33% | ||
| 6 | Broadfin Capital, LLC | 5,503,182 | 99,773,000 | 3.70% | ||
| 7 | JPMORGAN CHASE & CO | 4,316,681 | 78,261,000 | 2.90% | ||
| 8 | HealthCor Management, L.P. | 4,250,000 | 77,053,000 | 2.86% | ||
| 9 | STATE STREET CORP | 4,236,544 | 76,810,000 | 2.85% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 4,057,096 | 73,555,000 | 2.73% | ||
| 11 | JANUS HENDERSON INVESTORS US LLC | 3,815,813 | 69,181,000 | 2.57% | ||
| 12 | Consonance Capital Management LP | 3,698,903 | 67,061,000 | 2.49% | ||
| 13 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,650,700 | 66,187,000 | 2.46% | Call | |
| 14 | Brandywine Global Investment Management, LLC | 2,644,758 | 47,950,000 | 1.78% | ||
| 15 | TimesSquare Capital Management, LLC | 2,408,475 | 43,666,000 | 1.62% | ||
| 16 | GOLDMAN SACHS GROUP INC | 2,106,110 | 38,184,000 | 1.42% | ||
| 17 | GLENMEDE TRUST CO NA | 2,050,199 | 37,169,000 | 1.38% | ||
| 18 | DIMENSIONAL FUND ADVISORS LP | 1,965,305 | 35,627,000 | 1.32% | ||
| 19 | NORTHERN TRUST CORP | 1,923,251 | 34,868,000 | 1.29% | ||
| 20 | Scale Management, LLC | 1,710,451 | 31,010,000 | 1.15% | ||
| 21 | Fiera Capital Corp | 1,704,056 | 30,894,000 | 1.15% | ||
| 22 | EverPoint Asset Management, LLC | 1,675,000 | 30,368,000 | 1.13% | ||
| 23 | FRANKLIN RESOURCES INC | 1,474,100 | 26,726,000 | 0.99% | ||
| 24 | EAGLE ASSET MANAGEMENT INC | 1,463,170 | 26,527,000 | 0.98% | ||
| 25 | NORGES BANK | 1,493,746 | 25,866,000 | 0.96% | ||
| 26 | MORGAN STANLEY | 1,408,682 | 25,539,000 | 0.95% | ||
| 27 | NEXT CENTURY GROWTH INVESTORS LLC | 1,363,845 | 24,726,000 | 0.92% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,360,100 | 24,659,000 | 0.91% | Put | |
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,282,400 | 23,250,000 | 0.86% | Call | |
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 1,198,744 | 21,733,000 | 0.81% | ||
| 31 | Beach Point Capital Management LP | 1,162,751 | 21,081,000 | 0.78% | ||
| 32 | VOYA INVESTMENT MANAGEMENT LLC | 1,073,251 | 19,459,000 | 0.72% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,061,023 | 19,236,000 | 0.71% | ||
| 34 | Broadfin Capital, LLC | 1,050,000 | 19,037,000 | 0.71% | Call | |
| 35 | CAPITAL GROWTH MANAGEMENT LP | 1,000,000 | 18,130,000 | 0.67% | ||
| 36 | D. E. Shaw & Co., Inc. | 977,456 | 17,721,000 | 0.66% | ||
| 37 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 913,130 | 16,555,000 | 0.61% | ||
| 38 | UBS Group AG | 873,303 | 15,833,000 | 0.59% | ||
| 39 | TEACHERS ADVISORS, LLC | 864,348 | 15,671,000 | 0.58% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 825,108 | 14,960,000 | 0.55% | ||
| 41 | KENNEDY CAPITAL MANAGEMENT LLC | 759,005 | 13,761,000 | 0.51% | ||
| 42 | Bank of New York Mellon Corp | 750,930 | 13,614,000 | 0.51% | ||
| 43 | Tekla Capital Management LLC | 749,900 | 13,596,000 | 0.50% | ||
| 44 | C WorldWide Group Holding A/S | 747,600 | 13,554,000 | 0.50% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 729,476 | 13,226,000 | 0.49% | ||
| 46 | SAMLYN CAPITAL, LLC | 728,700 | 13,211,000 | 0.49% | ||
| 47 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 705,932 | 12,799,000 | 0.47% | ||
| 48 | TIGER MANAGEMENT L.L.C. | 673,933 | 12,218,000 | 0.45% | ||
| 49 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 647,783 | 11,744,000 | 0.44% | ||
| 50 | PANAGORA ASSET MANAGEMENT INC | 614,255 | 11,136,000 | 0.41% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
