| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 11,699,047 | 150,801,000 | 13.19% | ||
| 2 | Broadfin Capital, LLC | 8,917,975 | 114,953,000 | 10.06% | ||
| 3 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 6,074,616 | 78,302,000 | 6.85% | ||
| 4 | FMR LLC | 6,071,396 | 78,260,000 | 6.85% | ||
| 5 | HealthCor Management, L.P. | 5,600,000 | 72,184,000 | 6.31% | ||
| 6 | Visium Asset Management, LP | 4,492,524 | 57,910,000 | 5.07% | ||
| 7 | VANGUARD GROUP INC | 4,004,847 | 51,623,000 | 4.52% | ||
| 8 | STATE STREET CORP | 3,470,413 | 44,735,000 | 3.91% | ||
| 9 | Point72 Asset Management, L.P. | 2,614,700 | 33,703,000 | 2.95% | ||
| 10 | TimesSquare Capital Management, LLC | 2,584,000 | 33,308,000 | 2.91% | ||
| 11 | Scale Management, LLC | 2,204,563 | 28,417,000 | 2.49% | ||
| 12 | Murphy Michael R | 2,187,854 | 28,201,000 | 2.47% | ||
| 13 | BANK OF MONTREAL /CAN/ | 1,561,360 | 20,126,000 | 1.76% | ||
| 14 | D. E. Shaw & Co., Inc. | 1,407,304 | 18,140,000 | 1.59% | ||
| 15 | Tourbillon Capital Partners, L.P. | 1,250,000 | 16,113,000 | 1.41% | ||
| 16 | Bank of New York Mellon Corp | 1,112,693 | 14,343,000 | 1.25% | ||
| 17 | ORBIMED ADVISORS LLC | 1,075,000 | 13,857,000 | 1.21% | ||
| 18 | EMERALD ADVISERS, LLC | 935,655 | 12,061,000 | 1.06% | ||
| 19 | SYSTEMATIC FINANCIAL MANAGEMENT LP | 929,750 | 11,984,000 | 1.05% | ||
| 20 | Allianz Asset Management GmbH | 887,011 | 11,434,000 | 1.00% | ||
| 21 | PRICE T ROWE ASSOCIATES INC /MD/ | 866,700 | 11,172,000 | 0.98% | ||
| 22 | NEW YORK STATE COMMON RETIREMENT FUND | 812,275 | 10,470,000 | 0.92% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 803,719 | 10,360,000 | 0.91% | ||
| 24 | EverPoint Asset Management, LLC | 700,000 | 9,023,000 | 0.79% | ||
| 25 | NORTHERN TRUST CORP | 699,477 | 9,017,000 | 0.79% | ||
| 26 | Nicholas Investment Partners, LP | 631,038 | 8,134,000 | 0.71% | ||
| 27 | EMERALD MUTUAL FUND ADVISERS TRUST | 601,719 | 7,756,000 | 0.68% | ||
| 28 | CASTLEARK MANAGEMENT LLC | 601,500 | 7,753,000 | 0.68% | ||
| 29 | JW Asset Management, LLC | 580,684 | 7,485,000 | 0.65% | ||
| 30 | STIFEL FINANCIAL CORP | 539,913 | 6,959,000 | 0.61% | ||
| 31 | Jefferies Group LLC | 511,000 | 6,587,000 | 0.58% | Call | |
| 32 | OXFORD ASSET MANAGEMENT LLP | 509,771 | 6,489,000 | 0.57% | ||
| 33 | TURNER INVESTMENTS LLC | 499,134 | 6,434,000 | 0.56% | ||
| 34 | TANG CAPITAL MANAGEMENT LLC | 490,000 | 6,316,000 | 0.55% | ||
| 35 | BARCLAYS PLC | 471,800 | 5,662,000 | 0.50% | Call | |
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 409,100 | 5,273,000 | 0.46% | Call | |
| 37 | FORESTERS INVESTMENT MANAGEMENT COMPANY, INC. | 408,250 | 5,262,000 | 0.46% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 403,816 | 5,205,000 | 0.46% | ||
| 39 | Tygh Capital Management, Inc. | 394,830 | 5,089,000 | 0.45% | ||
| 40 | COWEN INC. | 390,066 | 5,019,000 | 0.44% | ||
| 41 | Connor, Clark & Lunn Investment Management Ltd. | 377,100 | 4,861,000 | 0.43% | ||
| 42 | BALYASNY ASSET MANAGEMENT L.P. | 370,000 | 4,769,000 | 0.42% | Put | |
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 235,402 | 3,922,000 | 0.34% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 302,711 | 3,902,000 | 0.34% | ||
| 45 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 300,000 | 3,867,000 | 0.34% | Call | |
| 46 | Broadfin Capital, LLC | 300,000 | 3,867,000 | 0.34% | Call | |
| 47 | Ghost Tree Capital, LLC | 300,000 | 3,867,000 | 0.34% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 280,070 | 3,610,000 | 0.32% | ||
| 49 | TUDOR INVESTMENT CORP ET AL | 274,577 | 3,539,000 | 0.31% | ||
| 50 | Timpani Capital Management LLC | 245,914 | 3,170,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
