| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 23,353,416 | 384,631,000 | 16.29% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 13,740,261 | 226,302,000 | 9.59% | ||
| 3 | VANGUARD GROUP INC | 10,569,177 | 174,074,000 | 7.37% | ||
| 4 | Broadfin Capital, LLC | 6,863,848 | 113,048,000 | 4.79% | ||
| 5 | BlackRock Fund Advisors | 6,678,136 | 109,989,000 | 4.66% | ||
| 6 | JPMORGAN CHASE & CO | 4,341,698 | 71,508,000 | 3.03% | ||
| 7 | STATE STREET CORP | 4,201,164 | 69,194,000 | 2.93% | ||
| 8 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 4,055,167 | 66,789,000 | 2.83% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 4,041,744 | 66,566,000 | 2.82% | ||
| 10 | TimesSquare Capital Management, LLC | 3,859,290 | 63,563,000 | 2.69% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 3,673,204 | 60,498,000 | 2.56% | ||
| 12 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 3,507,668 | 57,771,000 | 2.45% | ||
| 13 | Brandywine Global Investment Management, LLC | 2,809,382 | 46,271,000 | 1.96% | ||
| 14 | Beach Point Capital Management LP | 1,960,149 | 32,284,000 | 1.37% | ||
| 15 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,957,500 | 32,240,000 | 1.37% | Call | |
| 16 | EverPoint Asset Management, LLC | 1,800,000 | 29,646,000 | 1.26% | ||
| 17 | NORTHERN TRUST CORP | 1,775,906 | 29,250,000 | 1.24% | ||
| 18 | Fiera Capital Corp | 1,754,211 | 28,892,000 | 1.22% | ||
| 19 | Scale Management, LLC | 1,710,451 | 28,171,000 | 1.19% | ||
| 20 | NORGES BANK | 1,604,242 | 26,422,000 | 1.12% | ||
| 21 | FRANKLIN RESOURCES INC | 1,538,570 | 25,340,000 | 1.07% | ||
| 22 | DIMENSIONAL FUND ADVISORS LP | 1,458,520 | 24,026,000 | 1.02% | ||
| 23 | Allianz Asset Management GmbH | 1,181,369 | 19,457,000 | 0.82% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,127,000 | 18,562,000 | 0.79% | Put | |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 1,104,758 | 18,194,000 | 0.77% | ||
| 26 | UBS Group AG | 1,012,141 | 16,670,000 | 0.71% | ||
| 27 | DEUTSCHE BANK AG\ | 989,090 | 16,289,000 | 0.69% | ||
| 28 | D. E. Shaw & Co., Inc. | 927,514 | 15,276,000 | 0.65% | ||
| 29 | TIGER MANAGEMENT L.L.C. | 894,577 | 14,734,000 | 0.62% | ||
| 30 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 777,471 | 12,805,000 | 0.54% | ||
| 31 | Tekla Capital Management LLC | 749,900 | 12,351,000 | 0.52% | ||
| 32 | KENNEDY CAPITAL MANAGEMENT LLC | 726,469 | 11,965,000 | 0.51% | ||
| 33 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 719,184 | 11,845,000 | 0.50% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 715,559 | 11,786,000 | 0.50% | ||
| 35 | MORGAN STANLEY | 704,914 | 11,609,000 | 0.49% | ||
| 36 | Bank of New York Mellon Corp | 699,070 | 11,514,000 | 0.49% | ||
| 37 | C WorldWide Group Holding A/S | 665,000 | 10,953,000 | 0.46% | ||
| 38 | JW Asset Management, LLC | 629,075 | 10,361,000 | 0.44% | ||
| 39 | BANK OF MONTREAL /CAN/ | 618,861 | 10,193,000 | 0.43% | ||
| 40 | BlackRock Investment Management, LLC | 600,780 | 9,895,000 | 0.42% | ||
| 41 | BALYASNY ASSET MANAGEMENT L.P. | 534,640 | 8,806,000 | 0.37% | ||
| 42 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 517,300 | 8,520,000 | 0.36% | ||
| 43 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 509,860 | 8,397,000 | 0.36% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 503,967 | 8,300,000 | 0.35% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 500,829 | 8,249,000 | 0.35% | ||
| 46 | Broadfin Capital, LLC | 500,000 | 8,235,000 | 0.35% | Call | |
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 497,828 | 8,199,000 | 0.35% | ||
| 48 | PRICE T ROWE ASSOCIATES INC /MD/ | 492,485 | 8,111,000 | 0.34% | ||
| 49 | PANAGORA ASSET MANAGEMENT INC | 492,155 | 8,106,000 | 0.34% | ||
| 50 | NEUMEIER POMA INVESTMENT COUNSEL LLC | 491,410 | 8,094,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
