| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 12,792,689 | 332,226,000 | 12.67% | ||
| 2 | FMR LLC | 8,709,848 | 226,195,000 | 8.63% | ||
| 3 | Broadfin Capital, LLC | 7,053,504 | 183,179,000 | 6.99% | ||
| 4 | VANGUARD GROUP INC | 5,506,926 | 143,015,000 | 5.45% | ||
| 5 | HealthCor Management, L.P. | 4,000,000 | 103,880,000 | 3.96% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,697,140 | 96,015,000 | 3.66% | ||
| 7 | Visium Asset Management, LP | 2,960,546 | 76,885,000 | 2.93% | ||
| 8 | STATE STREET CORP | 2,705,746 | 70,269,000 | 2.68% | ||
| 9 | Tourbillon Capital Partners, L.P. | 2,665,000 | 69,210,000 | 2.64% | ||
| 10 | TimesSquare Capital Management, LLC | 2,115,500 | 54,940,000 | 2.10% | ||
| 11 | LionEye Capital Management LLC | 1,882,000 | 48,876,000 | 1.86% | ||
| 12 | Bank of New York Mellon Corp | 1,863,108 | 48,385,000 | 1.85% | ||
| 13 | Scale Management, LLC | 1,710,451 | 44,420,000 | 1.69% | ||
| 14 | CHARTWELL INVESTMENT PARTNERS, LLC | 1,708,880 | 44,380,000 | 1.69% | ||
| 15 | D. E. Shaw & Co., Inc. | 1,557,023 | 40,436,000 | 1.54% | ||
| 16 | CASTLEARK MANAGEMENT LLC | 1,519,050 | 39,450,000 | 1.50% | ||
| 17 | JPMORGAN CHASE & CO | 1,454,777 | 37,780,000 | 1.44% | ||
| 18 | KENNEDY CAPITAL MANAGEMENT LLC | 1,441,949 | 37,447,000 | 1.43% | ||
| 19 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,250,000 | 32,463,000 | 1.24% | Call | |
| 20 | LORD, ABBETT & CO. LLC | 1,124,104 | 29,193,000 | 1.11% | ||
| 21 | Beach Point Capital Management LP | 1,118,518 | 29,048,000 | 1.11% | ||
| 22 | ORBIMED ADVISORS LLC | 1,075,000 | 27,918,000 | 1.06% | ||
| 23 | GLENMEDE TRUST CO NA | 1,054,141 | 27,375,000 | 1.04% | ||
| 24 | BANK OF MONTREAL /CAN/ | 895,494 | 23,256,000 | 0.89% | ||
| 25 | PRICE T ROWE ASSOCIATES INC /MD/ | 862,000 | 22,386,000 | 0.85% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 803,719 | 20,873,000 | 0.80% | ||
| 27 | OXFORD ASSET MANAGEMENT LLP | 801,829 | 20,823,000 | 0.79% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 768,800 | 19,966,000 | 0.76% | Call | |
| 29 | NORTHERN TRUST CORP | 735,652 | 19,105,000 | 0.73% | ||
| 30 | JW Asset Management, LLC | 729,609 | 18,948,000 | 0.72% | ||
| 31 | Marble Arch Investments, LP | 720,000 | 18,698,000 | 0.71% | ||
| 32 | NEW YORK STATE COMMON RETIREMENT FUND | 673,655 | 17,495,000 | 0.67% | ||
| 33 | RICE HALL JAMES & ASSOCIATES, LLC | 664,904 | 17,268,000 | 0.66% | ||
| 34 | CITADEL ADVISORS LLC | 660,693 | 17,159,000 | 0.65% | ||
| 35 | WELLS FARGO & COMPANY/MN | 654,543 | 16,997,000 | 0.65% | ||
| 36 | DEUTSCHE BANK AG\ | 633,682 | 16,455,000 | 0.63% | ||
| 37 | Penn Capital Management Company, LLC | 580,251 | 15,069,000 | 0.57% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 578,111 | 15,014,000 | 0.57% | ||
| 39 | SYSTEMATIC FINANCIAL MANAGEMENT LP | 548,755 | 14,251,000 | 0.54% | ||
| 40 | Nicholas Investment Partners, LP | 542,990 | 14,101,000 | 0.54% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 534,900 | 13,891,000 | 0.53% | Put | |
| 42 | Allianz Asset Management GmbH | 507,761 | 13,187,000 | 0.50% | ||
| 43 | Zweig-DiMenna Associates LLC | 500,000 | 12,985,000 | 0.50% | ||
| 44 | Broadfin Capital, LLC | 500,000 | 12,985,000 | 0.50% | Call | |
| 45 | Tourbillon Capital Partners, L.P. | 500,000 | 12,985,000 | 0.50% | Call | |
| 46 | NEUMEIER POMA INVESTMENT COUNSEL LLC | 490,050 | 12,727,000 | 0.49% | ||
| 47 | STIFEL FINANCIAL CORP | 485,117 | 12,597,000 | 0.48% | ||
| 48 | EMERALD ADVISERS, LLC | 424,266 | 12,546,000 | 0.48% | ||
| 49 | TURNER INVESTMENTS LLC | 482,090 | 12,520,000 | 0.48% | ||
| 50 | GEODE CAPITAL MANAGEMENT, LLC | 463,955 | 12,048,000 | 0.46% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
