| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 22,546,090 | 783,251,000 | 17.31% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 12,259,875 | 425,908,000 | 9.41% | ||
| 3 | VANGUARD GROUP INC | 8,595,909 | 298,622,000 | 6.60% | ||
| 4 | Broadfin Capital, LLC | 4,815,807 | 167,301,000 | 3.70% | ||
| 5 | DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 4,190,340 | 145,572,000 | 3.22% | ||
| 6 | JPMORGAN CHASE & CO | 3,819,975 | 132,706,000 | 2.93% | ||
| 7 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 3,325,829 | 115,539,000 | 2.55% | ||
| 8 | LONE PINE CAPITAL LLC | 3,204,972 | 111,341,000 | 2.46% | ||
| 9 | HealthCor Management, L.P. | 3,200,000 | 111,168,000 | 2.46% | ||
| 10 | TimesSquare Capital Management, LLC | 2,783,240 | 96,690,000 | 2.14% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 2,154,395 | 74,844,000 | 1.65% | ||
| 12 | BlackRock Fund Advisors | 2,029,978 | 70,521,000 | 1.56% | ||
| 13 | HIGHLINE CAPITAL MANAGEMENT, L.P. | 1,930,000 | 67,048,000 | 1.48% | ||
| 14 | Marble Arch Investments, LP | 1,888,000 | 65,589,000 | 1.45% | ||
| 15 | D. E. Shaw & Co., Inc. | 1,805,525 | 62,724,000 | 1.39% | ||
| 16 | CITADEL ADVISORS LLC | 1,790,187 | 62,191,000 | 1.37% | ||
| 17 | Scale Management, LLC | 1,710,451 | 59,421,000 | 1.31% | ||
| 18 | Visium Asset Management, LP | 1,683,700 | 58,492,000 | 1.29% | ||
| 19 | LionEye Capital Management LLC | 1,381,000 | 47,976,000 | 1.06% | ||
| 20 | Ratan Capital Management LP | 1,321,300 | 45,902,000 | 1.01% | ||
| 21 | Bank of New York Mellon Corp | 1,258,665 | 43,726,000 | 0.97% | ||
| 22 | STATE STREET CORP | 1,226,095 | 42,593,000 | 0.94% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 1,216,800 | 42,272,000 | 0.93% | ||
| 24 | Broadfin Capital, LLC | 1,100,000 | 38,214,000 | 0.84% | Call | |
| 25 | Apex Capital Management | 1,024,469 | 35,590,000 | 0.79% | ||
| 26 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,016,389 | 35,309,000 | 0.78% | ||
| 27 | RS INVESTMENT MANAGEMENT CO LLC | 964,160 | 33,495,000 | 0.74% | ||
| 28 | ORBIMED ADVISORS LLC | 951,000 | 33,038,000 | 0.73% | ||
| 29 | Tourbillon Capital Partners, L.P. | 950,000 | 33,003,000 | 0.73% | ||
| 30 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 900,000 | 31,266,000 | 0.69% | Call | |
| 31 | JANUS HENDERSON INVESTORS US LLC | 893,695 | 31,047,000 | 0.69% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 889,778 | 30,910,000 | 0.68% | ||
| 33 | GOLDMAN SACHS GROUP INC | 873,069 | 30,330,000 | 0.67% | ||
| 34 | WELLS FARGO & COMPANY/MN | 810,421 | 28,155,000 | 0.62% | ||
| 35 | Beach Point Capital Management LP | 794,290 | 27,594,000 | 0.61% | ||
| 36 | BANK OF MONTREAL /CAN/ | 781,510 | 27,149,000 | 0.60% | ||
| 37 | JW Asset Management, LLC | 766,724 | 26,636,000 | 0.59% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 764,691 | 26,565,000 | 0.59% | ||
| 39 | KENNEDY CAPITAL MANAGEMENT LLC | 758,248 | 26,342,000 | 0.58% | ||
| 40 | NORTHERN TRUST CORP | 748,785 | 26,013,000 | 0.57% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 622,500 | 21,626,000 | 0.48% | Call | |
| 42 | CASTLEARK MANAGEMENT LLC | 610,600 | 21,212,000 | 0.47% | ||
| 43 | DEUTSCHE BANK AG\ | 607,289 | 21,096,000 | 0.47% | ||
| 44 | Zweig-DiMenna Associates LLC | 562,900 | 19,555,000 | 0.43% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 551,900 | 19,173,000 | 0.42% | ||
| 46 | MORGAN STANLEY | 549,501 | 19,089,000 | 0.42% | ||
| 47 | GLENMEDE TRUST CO NA | 542,278 | 18,838,000 | 0.42% | ||
| 48 | Nicholas Investment Partners, LP | 538,901 | 18,721,000 | 0.41% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 529,500 | 18,395,000 | 0.41% | Put | |
| 50 | GOLDMAN SACHS GROUP INC | 500,000 | 17,370,000 | 0.38% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
