| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 23,455,514 | 508,281,000 | 16.12% | ||
| 2 | LONE PINE CAPITAL LLC | 15,600,988 | 338,073,000 | 10.72% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 11,684,801 | 253,210,000 | 8.03% | ||
| 4 | VANGUARD GROUP INC | 9,567,662 | 207,331,000 | 6.58% | ||
| 5 | Broadfin Capital, LLC | 8,131,310 | 176,205,000 | 5.59% | ||
| 6 | TimesSquare Capital Management, LLC | 3,935,300 | 85,278,000 | 2.70% | ||
| 7 | JPMORGAN CHASE & CO | 3,276,598 | 71,003,000 | 2.25% | ||
| 8 | JANUS HENDERSON INVESTORS US LLC | 3,173,258 | 68,765,000 | 2.18% | ||
| 9 | Visium Asset Management, LP | 2,960,933 | 64,163,000 | 2.03% | ||
| 10 | BlackRock Fund Advisors | 2,729,296 | 59,144,000 | 1.88% | ||
| 11 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,519,955 | 54,607,000 | 1.73% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 2,276,496 | 49,332,000 | 1.56% | ||
| 13 | Brandywine Global Investment Management, LLC | 2,270,520 | 49,203,000 | 1.56% | ||
| 14 | RS INVESTMENT MANAGEMENT CO LLC | 2,210,448 | 47,900,000 | 1.52% | ||
| 15 | TEACHER RETIREMENT SYSTEM OF TEXAS | 2,136,961 | 46,308,000 | 1.47% | ||
| 16 | Gotham Asset Management, LLC | 2,075,017 | 44,966,000 | 1.43% | ||
| 17 | GOLDMAN SACHS GROUP INC | 2,019,268 | 43,757,000 | 1.39% | ||
| 18 | STATE STREET CORP | 1,732,843 | 37,553,000 | 1.19% | ||
| 19 | Apex Capital Management | 1,711,089 | 37,079,000 | 1.18% | ||
| 20 | Scale Management, LLC | 1,710,451 | 37,065,000 | 1.18% | ||
| 21 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 1,651,116 | 35,780,000 | 1.13% | ||
| 22 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,410,000 | 30,555,000 | 0.97% | Call | |
| 23 | NORGES BANK | 1,368,287 | 29,651,000 | 0.94% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,309,200 | 28,370,000 | 0.90% | Put | |
| 25 | Allianz Asset Management GmbH | 1,202,425 | 26,490,000 | 0.84% | ||
| 26 | UBS Group AG | 1,052,363 | 22,805,000 | 0.72% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 943,354 | 20,443,000 | 0.65% | ||
| 28 | GOLDMAN SACHS GROUP INC | 922,200 | 19,984,000 | 0.63% | Call | |
| 29 | BANK OF MONTREAL /CAN/ | 872,586 | 18,909,000 | 0.60% | ||
| 30 | TIGER MANAGEMENT L.L.C. | 823,577 | 17,847,000 | 0.57% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 808,100 | 17,512,000 | 0.56% | Call | |
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 803,143 | 17,404,000 | 0.55% | ||
| 33 | Tekla Capital Management LLC | 749,900 | 16,250,000 | 0.52% | ||
| 34 | NEUMEIER POMA INVESTMENT COUNSEL LLC | 739,485 | 16,025,000 | 0.51% | ||
| 35 | HIGHLAND CAPITAL MANAGEMENT LP | 728,807 | 15,793,000 | 0.50% | ||
| 36 | D. E. Shaw & Co., Inc. | 701,606 | 15,204,000 | 0.48% | ||
| 37 | JW Asset Management, LLC | 673,075 | 14,586,000 | 0.46% | ||
| 38 | C WorldWide Group Holding A/S | 661,500 | 14,335,000 | 0.45% | ||
| 39 | DEUTSCHE BANK AG\ | 633,015 | 13,716,000 | 0.44% | ||
| 40 | OXFORD ASSET MANAGEMENT LLP | 582,449 | 12,971,000 | 0.41% | ||
| 41 | KENNEDY CAPITAL MANAGEMENT LLC | 566,980 | 12,286,000 | 0.39% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 557,772 | 12,089,000 | 0.38% | ||
| 43 | RAINIER INVESTMENT MANAGEMENT LLC | 553,870 | 12,002,000 | 0.38% | ||
| 44 | MORGAN STANLEY | 548,234 | 11,881,000 | 0.38% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 540,900 | 11,721,000 | 0.37% | ||
| 46 | GOLDMAN SACHS GROUP INC | 521,600 | 11,303,000 | 0.36% | Put | |
| 47 | NEXT CENTURY GROWTH INVESTORS LLC | 519,383 | 11,255,000 | 0.36% | ||
| 48 | RUSSELL FRANK CO/ | 498,110 | 11,147,000 | 0.35% | ||
| 49 | CITADEL ADVISORS LLC | 512,716 | 11,111,000 | 0.35% | ||
| 50 | Broadfin Capital, LLC | 500,000 | 10,835,000 | 0.34% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
