| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GREAT POINT PARTNERS LLC | 4,781,708 | 22,187,000 | 21.75% | ||
| 2 | BAKER BROS. ADVISORS LP | 2,466,702 | 11,445,000 | 11.22% | ||
| 3 | FRANKLIN RESOURCES INC | 1,499,370 | 6,957,000 | 6.82% | ||
| 4 | DSC Advisors, L.P. | 1,186,654 | 5,506,000 | 5.40% | ||
| 5 | Opaleye Management Inc. | 1,135,000 | 5,266,000 | 5.16% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 1,117,324 | 5,184,000 | 5.08% | ||
| 7 | AXA S.A. | 942,735 | 4,374,000 | 4.29% | ||
| 8 | Tekla Capital Management LLC | 930,398 | 4,317,000 | 4.23% | ||
| 9 | VIVO CAPITAL, LLC | 855,000 | 3,967,000 | 3.89% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 817,435 | 3,793,000 | 3.72% | ||
| 11 | MARSHALL WACE NORTH AMERICA, L.P. | 632,819 | 3,164,000 | 3.10% | ||
| 12 | SENZAR ASSET MANAGEMENT, LLC | 569,197 | 2,641,000 | 2.59% | ||
| 13 | Bank of New York Mellon Corp | 544,853 | 2,528,000 | 2.48% | ||
| 14 | BlackRock Finance, Inc. | 535,403 | 2,484,000 | 2.44% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 509,535 | 2,364,000 | 2.32% | ||
| 16 | FOLGER HILL ASSET MANAGEMENT LP | 451,869 | 2,097,000 | 2.06% | ||
| 17 | INTERNATIONAL BIOTECHNOLOGY TRUST PLC | 358,975 | 1,666,000 | 1.63% | ||
| 18 | DAFNA Capital Management LLC | 355,667 | 1,650,000 | 1.62% | ||
| 19 | JENNISON ASSOCIATES LLC | 331,658 | 1,539,000 | 1.51% | ||
| 20 | BAILLIE GIFFORD & CO | 219,400 | 1,018,000 | 1.00% | ||
| 21 | Alyeska Investment Group, L.P. | 205,870 | 955,000 | 0.94% | ||
| 22 | Crestline Management, LP | 177,488 | 824,000 | 0.81% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 154,900 | 719,000 | 0.70% | ||
| 24 | Sio Capital Management, LLC | 139,200 | 646,000 | 0.63% | ||
| 25 | GOLDMAN SACHS GROUP INC | 126,280 | 586,000 | 0.57% | ||
| 26 | Ghost Tree Capital, LLC | 125,000 | 580,000 | 0.57% | ||
| 27 | MILLENNIUM MANAGEMENT LLC | 123,085 | 571,000 | 0.56% | ||
| 28 | DEUTSCHE BANK AG\ | 108,222 | 502,000 | 0.49% | ||
| 29 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 106,312 | 493,288 | 0.48% | ||
| 30 | PDT Partners, LLC | 65,500 | 304,000 | 0.30% | ||
| 31 | RAYMOND JAMES & ASSOCIATES | 42,500 | 197,000 | 0.19% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 34,100 | 158,000 | 0.15% | Put | |
| 33 | MENORA MIVTACHIM HOLDINGS LTD. | 29,340 | 136,000 | 0.13% | ||
| 34 | PURA VIDA INVESTMENTS, LLC | 24,100 | 112,000 | 0.11% | ||
| 35 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 23,000 | 107,000 | 0.10% | ||
| 36 | ETF MANAGERS GROUP, LLC | 20,927 | 97,000 | 0.10% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 19,970 | 92,000 | 0.09% | ||
| 38 | ProShare Advisors LLC | 19,108 | 89,000 | 0.09% | ||
| 39 | A.R.T. Advisors, LLC | 18,308 | 84,000 | 0.08% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,887 | 78,000 | 0.08% | ||
| 41 | D. E. Shaw & Co., Inc. | 16,327 | 76,000 | 0.07% | ||
| 42 | IPG Investment Advisors LLC | 14,575 | 67,628 | 0.07% | ||
| 43 | GROUP ONE TRADING LLC | 13,791 | 64,000 | 0.06% | ||
| 44 | SIMPLEX TRADING, LLC | 12,934 | 60,000 | 0.06% | ||
| 45 | JPMORGAN CHASE & CO | 11,806 | 55,000 | 0.05% | ||
| 46 | VAN ECK ASSOCIATES CORP | 10,844 | 50,000 | 0.05% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 10,116 | 47,000 | 0.05% | ||
| 48 | VICTORY CAPITAL MANAGEMENT INC | 7,252 | 34,000 | 0.03% | ||
| 49 | Tower Research Capital LLC (TRC) | 4,872 | 23,000 | 0.02% | ||
| 50 | Creative Planning | 3,000 | 14,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
