| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 3,452,493 | 45,330,000 | 30.91% | ||
| 2 | ORBIMED ADVISORS LLC | 2,175,857 | 28,569,000 | 19.48% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,591,546 | 20,897,000 | 14.25% | ||
| 4 | BVF INC/IL | 1,192,202 | 15,654,000 | 10.67% | ||
| 5 | RS INVESTMENT MANAGEMENT CO LLC | 599,400 | 7,870,000 | 5.37% | ||
| 6 | Redmile Group, LLC | 540,300 | 7,094,000 | 4.84% | ||
| 7 | DRIEHAUS CAPITAL MANAGEMENT LLC | 365,566 | 4,800,000 | 3.27% | ||
| 8 | Visium Asset Management, LP | 332,516 | 4,366,000 | 2.98% | ||
| 9 | JENNISON ASSOCIATES LLC | 125,000 | 1,641,000 | 1.12% | ||
| 10 | AXA S.A. | 125,000 | 1,641,000 | 1.12% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 100,000 | 1,313,000 | 0.90% | ||
| 12 | BAKER BROS. ADVISORS LP | 100,000 | 1,313,000 | 0.90% | ||
| 13 | BlackRock Fund Advisors | 80,319 | 1,055,000 | 0.72% | ||
| 14 | MARXE AUSTIN W & GREENHOUSE DAVID M | 75,000 | 985,000 | 0.67% | ||
| 15 | Nicholas Investment Partners, LP | 73,341 | 963,000 | 0.66% | ||
| 16 | Alyeska Investment Group, L.P. | 50,449 | 662,000 | 0.45% | ||
| 17 | GOLDMAN SACHS GROUP INC | 40,040 | 526,000 | 0.36% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 27,765 | 365,000 | 0.25% | ||
| 19 | Bank of New York Mellon Corp | 19,173 | 252,000 | 0.17% | ||
| 20 | STATE STREET CORP | 17,100 | 226,000 | 0.15% | ||
| 21 | Spark Investment Management LLC | 15,400 | 199,000 | 0.14% | ||
| 22 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 12,532 | 165,000 | 0.11% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,310 | 149,000 | 0.10% | ||
| 24 | DEUTSCHE BANK AG\ | 9,010 | 118,000 | 0.08% | ||
| 25 | BlackRock Investment Management, LLC | 8,440 | 111,000 | 0.08% | ||
| 26 | Nationwide Fund Advisors | 7,125 | 94,000 | 0.06% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,700 | 88,000 | 0.06% | ||
| 28 | MORGAN STANLEY | 5,631 | 74,000 | 0.05% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 4,879 | 64,000 | 0.04% | ||
| 30 | TEACHERS ADVISORS, LLC | 3,373 | 44,000 | 0.03% | ||
| 31 | STRS OHIO | 1,200 | 16,000 | 0.01% | ||
| 32 | BLACKROCK ADVISORS LLC | 1,214 | 16,000 | 0.01% | ||
| 33 | MANAGED ACCOUNT ADVISORS LLC | 674 | 9,000 | 0.01% | ||
| 34 | UBS AG | 155 | 2,000 | 0.00% | ||
| 35 | CITIGROUP INC | 127 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
