| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 4,028,920 | 93,390,000 | 19.49% | ||
| 2 | FMR LLC | 3,199,856 | 74,173,000 | 15.48% | ||
| 3 | ORBIMED ADVISORS LLC | 2,175,857 | 50,436,000 | 10.52% | ||
| 4 | NEA Management Company, LLC | 1,792,207 | 41,543,000 | 8.67% | ||
| 5 | RS INVESTMENT MANAGEMENT CO LLC | 1,505,004 | 34,886,000 | 7.28% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 1,288,106 | 29,858,000 | 6.23% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 817,500 | 18,950,000 | 3.95% | ||
| 8 | EVENTIDE ASSET MANAGEMENT, LLC | 740,000 | 17,153,000 | 3.58% | ||
| 9 | VANGUARD GROUP INC | 499,283 | 11,573,000 | 2.41% | ||
| 10 | BlackRock Fund Advisors | 344,956 | 7,996,000 | 1.67% | ||
| 11 | DRIEHAUS CAPITAL MANAGEMENT LLC | 315,024 | 7,302,000 | 1.52% | ||
| 12 | CASDIN CAPITAL, LLC | 300,000 | 6,954,000 | 1.45% | ||
| 13 | FRANKLIN RESOURCES INC | 275,000 | 6,375,000 | 1.33% | ||
| 14 | Capital World Investors | 262,000 | 6,073,000 | 1.27% | ||
| 15 | AXA S.A. | 260,412 | 6,036,000 | 1.26% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 251,000 | 5,818,000 | 1.21% | ||
| 17 | PAULSON & CO. INC. | 250,341 | 5,803,000 | 1.21% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 215,369 | 4,992,000 | 1.04% | ||
| 19 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 209,098 | 4,847,000 | 1.01% | ||
| 20 | STATE STREET CORP | 201,021 | 4,658,000 | 0.97% | ||
| 21 | Informed Momentum Co LLC | 199,730 | 4,630,000 | 0.97% | ||
| 22 | AWM Investment Company, Inc. | 190,000 | 4,404,000 | 0.92% | ||
| 23 | NORTHERN TRUST CORP | 165,048 | 3,826,000 | 0.80% | ||
| 24 | BAKER BROS. ADVISORS LP | 137,735 | 3,193,000 | 0.67% | ||
| 25 | DAFNA Capital Management LLC | 101,966 | 2,364,000 | 0.49% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 97,293 | 2,255,000 | 0.47% | ||
| 27 | Bank of New York Mellon Corp | 97,137 | 2,252,000 | 0.47% | ||
| 28 | Nicholas Investment Partners, LP | 67,655 | 1,568,000 | 0.33% | ||
| 29 | JPMORGAN CHASE & CO | 62,861 | 1,457,000 | 0.30% | ||
| 30 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 61,440 | 1,424,000 | 0.30% | ||
| 31 | AMERIPRISE FINANCIAL INC | 59,357 | 1,376,000 | 0.29% | ||
| 32 | BlackRock Investment Management, LLC | 51,650 | 1,197,000 | 0.25% | ||
| 33 | EMERALD ACQUISITION LTD. | 39,612 | 918,000 | 0.19% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 39,326 | 912,000 | 0.19% | ||
| 35 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 30,250 | 701,000 | 0.15% | ||
| 36 | ALPS ADVISORS INC | 30,015 | 696,000 | 0.15% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,964 | 648,000 | 0.14% | ||
| 38 | Nationwide Fund Advisors | 23,392 | 542,000 | 0.11% | ||
| 39 | TEACHERS ADVISORS, LLC | 21,234 | 492,000 | 0.10% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 20,600 | 478,000 | 0.10% | ||
| 41 | Swiss National Bank | 20,200 | 468,000 | 0.10% | ||
| 42 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 16,457 | 381,000 | 0.08% | ||
| 43 | SECOR Capital Advisors, LP | 14,640 | 340,000 | 0.07% | ||
| 44 | GSA CAPITAL PARTNERS LLP | 14,440 | 335,000 | 0.07% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 14,473 | 335,000 | 0.07% | ||
| 46 | AQR CAPITAL MANAGEMENT LLC | 14,272 | 331,000 | 0.07% | ||
| 47 | DEUTSCHE BANK AG\ | 12,765 | 294,000 | 0.06% | ||
| 48 | RHUMBLINE ADVISERS | 11,699 | 271,000 | 0.06% | ||
| 49 | STRS OHIO | 11,200 | 259,000 | 0.05% | ||
| 50 | METROPOLITAN LIFE INSURANCE CO/NY | 10,559 | 245,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
