| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 3,452,493 | 40,567,000 | 27.02% | ||
| 2 | ORBIMED ADVISORS LLC | 2,175,857 | 25,566,000 | 17.03% | ||
| 3 | NEA Management Company, LLC | 1,792,207 | 21,058,000 | 14.03% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,591,546 | 18,701,000 | 12.46% | ||
| 5 | BVF INC/IL | 1,190,702 | 13,991,000 | 9.32% | ||
| 6 | RS INVESTMENT MANAGEMENT CO LLC | 734,141 | 8,626,000 | 5.75% | ||
| 7 | Visium Asset Management, LP | 400,000 | 4,700,000 | 3.13% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 383,648 | 4,508,000 | 3.00% | ||
| 9 | Redmile Group, LLC | 137,681 | 1,618,000 | 1.08% | ||
| 10 | AXA S.A. | 133,545 | 1,569,000 | 1.05% | ||
| 11 | BAKER BROS. ADVISORS LP | 100,000 | 1,175,000 | 0.78% | ||
| 12 | BlackRock Fund Advisors | 96,906 | 1,139,000 | 0.76% | ||
| 13 | AWM Investment Company, Inc. | 75,000 | 881,000 | 0.59% | ||
| 14 | Alyeska Investment Group, L.P. | 68,649 | 807,000 | 0.54% | ||
| 15 | Nicholas Investment Partners, LP | 60,505 | 711,000 | 0.47% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 48,750 | 573,000 | 0.38% | ||
| 17 | NORTHERN TRUST CORP | 37,266 | 438,000 | 0.29% | ||
| 18 | VANGUARD GROUP INC | 35,707 | 420,000 | 0.28% | ||
| 19 | MILLENNIUM MANAGEMENT LLC | 35,616 | 418,000 | 0.28% | ||
| 20 | STATE STREET CORP | 33,800 | 395,000 | 0.26% | ||
| 21 | GOLDMAN SACHS GROUP INC | 29,107 | 342,000 | 0.23% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 27,795 | 326,000 | 0.22% | ||
| 23 | BLACKROCK ADVISORS LLC | 24,062 | 283,000 | 0.19% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 21,031 | 247,000 | 0.16% | ||
| 25 | Bank of New York Mellon Corp | 20,264 | 238,000 | 0.16% | ||
| 26 | DEUTSCHE BANK AG\ | 12,715 | 149,000 | 0.10% | ||
| 27 | Nationwide Fund Advisors | 12,553 | 147,000 | 0.10% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 12,532 | 138,000 | 0.09% | ||
| 29 | BlackRock Investment Management, LLC | 9,079 | 107,000 | 0.07% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,729 | 79,000 | 0.05% | ||
| 31 | BlackRock Group LTD | 6,122 | 72,000 | 0.05% | ||
| 32 | TEACHERS ADVISORS, LLC | 3,373 | 40,000 | 0.03% | ||
| 33 | BlackRock Japan Co. Ltd | 3,363 | 40,000 | 0.03% | ||
| 34 | AMERICAN INTERNATIONAL GROUP, INC. | 2,276 | 26,743 | 0.02% | ||
| 35 | STRS OHIO | 1,200 | 14,000 | 0.01% | ||
| 36 | MANAGED ACCOUNT ADVISORS LLC | 605 | 7,000 | 0.00% | ||
| 37 | CITIGROUP INC | 620 | 7,000 | 0.00% | ||
| 38 | MORGAN STANLEY | 502 | 6,000 | 0.00% | ||
| 39 | UBS Group AG | 399 | 5,000 | 0.00% | ||
| 40 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 300 | 4,000 | 0.00% | ||
| 41 | BARCLAYS PLC | 206 | 2,000 | 0.00% | ||
| 42 | WELLS FARGO & COMPANY/MN | 168 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
