| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 3,796,362 | 103,793,000 | 20.55% | ||
| 2 | FMR LLC | 2,947,659 | 80,589,000 | 15.95% | ||
| 3 | ORBIMED ADVISORS LLC | 2,175,857 | 59,488,000 | 11.78% | ||
| 4 | NEA Management Company, LLC | 1,792,207 | 48,999,000 | 9.70% | ||
| 5 | RS INVESTMENT MANAGEMENT CO LLC | 1,406,966 | 38,466,000 | 7.61% | ||
| 6 | EVENTIDE ASSET MANAGEMENT, LLC | 740,000 | 20,232,000 | 4.01% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | 19,138,000 | 3.79% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 494,432 | 13,518,000 | 2.68% | ||
| 9 | DRIEHAUS CAPITAL MANAGEMENT LLC | 331,041 | 9,051,000 | 1.79% | ||
| 10 | PointState Capital LP | 280,000 | 7,655,000 | 1.52% | ||
| 11 | VANGUARD GROUP INC | 277,382 | 7,583,000 | 1.50% | ||
| 12 | AXA S.A. | 271,100 | 7,412,000 | 1.47% | ||
| 13 | Capital World Investors | 262,000 | 7,163,000 | 1.42% | ||
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 251,000 | 6,862,000 | 1.36% | ||
| 15 | CASDIN CAPITAL, LLC | 250,000 | 6,835,000 | 1.35% | ||
| 16 | BlackRock Fund Advisors | 232,746 | 6,363,000 | 1.26% | ||
| 17 | PAULSON & CO. INC. | 225,341 | 6,161,000 | 1.22% | ||
| 18 | Informed Momentum Co LLC | 214,859 | 5,874,000 | 1.16% | ||
| 19 | AWM Investment Company, Inc. | 200,000 | 5,468,000 | 1.08% | ||
| 20 | EcoR1 Capital, LLC | 150,308 | 4,109,000 | 0.81% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 148,490 | 4,060,000 | 0.80% | ||
| 22 | BAKER BROS. ADVISORS LP | 137,735 | 3,766,000 | 0.75% | ||
| 23 | STATE STREET CORP | 133,074 | 3,638,000 | 0.72% | ||
| 24 | NORTHERN TRUST CORP | 91,898 | 2,513,000 | 0.50% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 80,344 | 2,197,000 | 0.43% | ||
| 26 | BVF INC/IL | 74,870 | 2,047,000 | 0.41% | ||
| 27 | Bank of New York Mellon Corp | 70,537 | 1,928,000 | 0.38% | ||
| 28 | AMERIPRISE FINANCIAL INC | 63,716 | 1,742,000 | 0.34% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 57,068 | 1,560,000 | 0.31% | ||
| 30 | Nicholas Investment Partners, LP | 56,645 | 1,549,000 | 0.31% | ||
| 31 | Invesco Ltd. | 55,593 | 1,520,000 | 0.30% | ||
| 32 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 50,392 | 1,378,000 | 0.27% | ||
| 33 | RUSSELL FRANK CO/ | 42,836 | 1,171,000 | 0.23% | ||
| 34 | DAFNA Capital Management LLC | 39,000 | 1,066,000 | 0.21% | ||
| 35 | BlackRock Investment Management, LLC | 36,356 | 994,000 | 0.20% | ||
| 36 | Opus Point Partners Management, LLC | 36,000 | 984,000 | 0.19% | ||
| 37 | OXFORD ASSET MANAGEMENT LLP | 35,225 | 963,000 | 0.19% | ||
| 38 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 30,200 | 826,000 | 0.16% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 28,706 | 785,000 | 0.16% | ||
| 40 | ALPS ADVISORS INC | 21,578 | 590,000 | 0.12% | ||
| 41 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,572 | 535,000 | 0.11% | ||
| 42 | AQR CAPITAL MANAGEMENT LLC | 14,272 | 390,000 | 0.08% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 13,950 | 381,000 | 0.08% | ||
| 44 | TEACHERS ADVISORS, LLC | 13,493 | 369,000 | 0.07% | ||
| 45 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 13,235 | 362,000 | 0.07% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,200 | 361,000 | 0.07% | ||
| 47 | GSA CAPITAL PARTNERS LLP | 12,700 | 347,000 | 0.07% | ||
| 48 | RHUMBLINE ADVISERS | 12,657 | 346,000 | 0.07% | ||
| 49 | STRS OHIO | 10,300 | 281,000 | 0.06% | ||
| 50 | DEUTSCHE BANK AG\ | 9,723 | 264,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
