| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 3,452,493 | 62,248,000 | 23.90% | ||
| 2 | ORBIMED ADVISORS LLC | 2,175,857 | 39,231,000 | 15.06% | ||
| 3 | NEA Management Company, LLC | 1,792,207 | 32,313,000 | 12.41% | ||
| 4 | BVF INC/IL | 1,615,081 | 29,120,000 | 11.18% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,450,151 | 26,146,000 | 10.04% | ||
| 6 | RS INVESTMENT MANAGEMENT CO LLC | 1,192,401 | 21,499,000 | 8.25% | ||
| 7 | DRIEHAUS CAPITAL MANAGEMENT LLC | 465,716 | 8,397,000 | 3.22% | ||
| 8 | Visium Asset Management, LP | 400,000 | 7,212,000 | 2.77% | ||
| 9 | EVENTIDE ASSET MANAGEMENT, LLC | 243,700 | 4,394,000 | 1.69% | ||
| 10 | AXA S.A. | 214,864 | 3,874,000 | 1.49% | ||
| 11 | BlackRock Fund Advisors | 197,270 | 3,557,000 | 1.37% | ||
| 12 | VANGUARD GROUP INC | 177,478 | 3,200,000 | 1.23% | ||
| 13 | JPMORGAN CHASE & CO | 166,000 | 2,993,000 | 1.15% | ||
| 14 | BAKER BROS. ADVISORS LP | 100,000 | 1,803,000 | 0.69% | ||
| 15 | Alyeska Investment Group, L.P. | 79,545 | 1,434,000 | 0.55% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 79,352 | 1,431,000 | 0.55% | ||
| 17 | Informed Momentum Co LLC | 76,807 | 1,385,000 | 0.53% | ||
| 18 | AWM Investment Company, Inc. | 75,000 | 1,352,000 | 0.52% | ||
| 19 | Nicholas Investment Partners, LP | 62,626 | 1,129,000 | 0.43% | ||
| 20 | STATE STREET CORP | 49,000 | 884,000 | 0.34% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 47,000 | 847,000 | 0.33% | ||
| 22 | Bank of New York Mellon Corp | 43,535 | 786,000 | 0.30% | ||
| 23 | NORTHERN TRUST CORP | 40,588 | 732,000 | 0.28% | ||
| 24 | BLACKROCK ADVISORS LLC | 36,363 | 656,000 | 0.25% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 33,660 | 606,000 | 0.23% | ||
| 26 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 30,000 | 541,000 | 0.21% | ||
| 27 | BlackRock Investment Management, LLC | 29,139 | 525,000 | 0.20% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 25,788 | 465,000 | 0.18% | ||
| 29 | Nationwide Fund Advisors | 14,958 | 270,000 | 0.10% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,213 | 256,000 | 0.10% | ||
| 31 | DAFNA Capital Management LLC | 12,245 | 221,000 | 0.08% | ||
| 32 | TEACHERS ADVISORS, LLC | 11,552 | 208,000 | 0.08% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 11,516 | 208,000 | 0.08% | ||
| 34 | BlackRock Group LTD | 7,924 | 143,000 | 0.05% | ||
| 35 | PANAGORA ASSET MANAGEMENT INC | 5,153 | 93,000 | 0.04% | ||
| 36 | AMERICAN INTERNATIONAL GROUP, INC. | 4,561 | 82,235 | 0.03% | ||
| 37 | DEUTSCHE BANK AG\ | 2,284 | 39,000 | 0.01% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 2,087 | 38,000 | 0.01% | ||
| 39 | UBS Group AG | 1,827 | 33,000 | 0.01% | ||
| 40 | WELLS FARGO & COMPANY/MN | 1,390 | 25,000 | 0.01% | ||
| 41 | BlackRock Japan Co. Ltd | 918 | 17,000 | 0.01% | ||
| 42 | BNP PARIBAS FINANCIAL MARKETS | 648 | 11,683 | 0.00% | ||
| 43 | MANAGED ACCOUNT ADVISORS LLC | 601 | 11,000 | 0.00% | ||
| 44 | ROYAL BANK OF CANADA | 455 | 8,000 | 0.00% | ||
| 45 | MORGAN STANLEY | 286 | 6,000 | 0.00% | ||
| 46 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 300 | 5,000 | 0.00% | ||
| 47 | Invesco Ltd. | 279 | 5,000 | 0.00% | ||
| 48 | GLENMEDE TRUST CO NA | 290 | 5,000 | 0.00% | ||
| 49 | CITIGROUP INC | 210 | 4,000 | 0.00% | ||
| 50 | BARCLAYS PLC | 150 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
