| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 4,028,920 | 105,477,000 | 19.37% | ||
| 2 | FMR LLC | 3,249,649 | 85,076,000 | 15.62% | ||
| 3 | ORBIMED ADVISORS LLC | 1,728,000 | 45,239,000 | 8.31% | ||
| 4 | VICTORY CAPITAL MANAGEMENT INC | 1,610,334 | 42,158,000 | 7.74% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 1,601,534 | 41,928,000 | 7.70% | ||
| 6 | NEA Management Company, LLC | 1,289,420 | 33,757,000 | 6.20% | ||
| 7 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 817,500 | 21,402,000 | 3.93% | ||
| 8 | EVENTIDE ASSET MANAGEMENT, LLC | 740,000 | 19,373,000 | 3.56% | ||
| 9 | PAULSON & CO. INC. | 736,941 | 19,293,000 | 3.54% | ||
| 10 | VANGUARD GROUP INC | 505,141 | 13,225,000 | 2.43% | ||
| 11 | BlackRock Fund Advisors | 368,439 | 9,646,000 | 1.77% | ||
| 12 | DRIEHAUS CAPITAL MANAGEMENT LLC | 342,765 | 8,974,000 | 1.65% | ||
| 13 | CASDIN CAPITAL, LLC | 291,000 | 7,618,000 | 1.40% | ||
| 14 | FRANKLIN RESOURCES INC | 275,000 | 7,200,000 | 1.32% | ||
| 15 | Capital World Investors | 262,000 | 6,859,000 | 1.26% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 251,000 | 6,571,000 | 1.21% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 239,490 | 6,270,000 | 1.15% | ||
| 18 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 230,575 | 6,037,000 | 1.11% | ||
| 19 | STATE STREET CORP | 209,961 | 5,497,000 | 1.01% | ||
| 20 | AXA S.A. | 198,939 | 5,208,000 | 0.96% | ||
| 21 | AWM Investment Company, Inc. | 180,000 | 4,712,000 | 0.87% | ||
| 22 | NORTHERN TRUST CORP | 161,382 | 4,225,000 | 0.78% | ||
| 23 | BAKER BROS. ADVISORS LP | 137,735 | 3,606,000 | 0.66% | ||
| 24 | DAFNA Capital Management LLC | 130,222 | 3,409,000 | 0.63% | ||
| 25 | Opaleye Management Inc. | 110,000 | 2,880,000 | 0.53% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 100,780 | 2,638,000 | 0.48% | ||
| 27 | Informed Momentum Co LLC | 85,061 | 2,227,000 | 0.41% | ||
| 28 | JPMORGAN CHASE & CO | 76,867 | 2,012,000 | 0.37% | ||
| 29 | Artal Group S.A. | 75,000 | 1,964,000 | 0.36% | ||
| 30 | Nicholas Investment Partners, LP | 67,655 | 1,771,000 | 0.33% | ||
| 31 | Bank of New York Mellon Corp | 65,767 | 1,721,000 | 0.32% | ||
| 32 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 62,260 | 1,630,000 | 0.30% | ||
| 33 | BlackRock Investment Management, LLC | 51,549 | 1,350,000 | 0.25% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 41,049 | 1,075,000 | 0.20% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 39,653 | 1,038,000 | 0.19% | ||
| 36 | TEACHER RETIREMENT SYSTEM OF TEXAS | 34,933 | 915,000 | 0.17% | ||
| 37 | PRICE T ROWE ASSOCIATES INC /MD/ | 33,163 | 868,000 | 0.16% | ||
| 38 | Invesco Ltd. | 33,119 | 867,000 | 0.16% | ||
| 39 | EMERALD ACQUISITION LTD. | 32,042 | 839,000 | 0.15% | ||
| 40 | ALPS ADVISORS INC | 27,618 | 723,000 | 0.13% | ||
| 41 | Nationwide Fund Advisors | 21,892 | 573,000 | 0.11% | ||
| 42 | TEACHERS ADVISORS, LLC | 21,234 | 556,000 | 0.10% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 18,873 | 494,000 | 0.09% | ||
| 44 | Swiss National Bank | 18,700 | 490,000 | 0.09% | ||
| 45 | DEUTSCHE BANK AG\ | 16,920 | 440,000 | 0.08% | ||
| 46 | AQR CAPITAL MANAGEMENT LLC | 16,787 | 439,000 | 0.08% | ||
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 14,422 | 378,000 | 0.07% | ||
| 48 | STRS OHIO | 13,089 | 342,000 | 0.06% | ||
| 49 | SECOR Capital Advisors, LP | 12,887 | 337,000 | 0.06% | ||
| 50 | RHUMBLINE ADVISERS | 12,574 | 329,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
