| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 4,028,920 | 129,409,000 | 19.12% | ||
| 2 | FMR LLC | 3,251,707 | 104,429,000 | 15.43% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 1,814,142 | 58,262,000 | 8.61% | ||
| 4 | ORBIMED ADVISORS LLC | 1,728,000 | 55,495,000 | 8.20% | ||
| 5 | VICTORY CAPITAL MANAGEMENT INC | 1,481,121 | 47,566,000 | 7.03% | ||
| 6 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,170,000 | 37,575,000 | 5.55% | ||
| 7 | PAULSON & CO. INC. | 828,641 | 26,612,000 | 3.93% | ||
| 8 | EVENTIDE ASSET MANAGEMENT, LLC | 740,000 | 23,765,000 | 3.51% | ||
| 9 | BlackRock Fund Advisors | 722,972 | 23,218,000 | 3.43% | ||
| 10 | VANGUARD GROUP INC | 513,411 | 16,488,000 | 2.44% | ||
| 11 | DRIEHAUS CAPITAL MANAGEMENT LLC | 423,276 | 13,594,000 | 2.01% | ||
| 12 | CASDIN CAPITAL, LLC | 360,000 | 11,561,000 | 1.71% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 319,470 | 10,260,000 | 1.52% | ||
| 14 | FRANKLIN RESOURCES INC | 275,000 | 8,832,000 | 1.30% | ||
| 15 | DEERFIELD MANAGEMENT COMPANY, L.P. | 251,000 | 8,061,000 | 1.19% | ||
| 16 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 215,956 | 6,936,000 | 1.02% | ||
| 17 | STATE STREET CORP | 214,321 | 6,882,000 | 1.02% | ||
| 18 | AXA S.A. | 203,087 | 6,522,000 | 0.96% | ||
| 19 | AWM Investment Company, Inc. | 180,000 | 5,781,000 | 0.85% | ||
| 20 | NORTHERN TRUST CORP | 165,841 | 5,326,000 | 0.79% | ||
| 21 | DAFNA Capital Management LLC | 139,722 | 4,487,000 | 0.66% | ||
| 22 | BAKER BROS. ADVISORS LP | 137,735 | 4,423,000 | 0.65% | ||
| 23 | Opaleye Management Inc. | 125,000 | 4,014,000 | 0.59% | ||
| 24 | Informed Momentum Co LLC | 111,268 | 3,573,000 | 0.53% | ||
| 25 | Artal Group S.A. | 100,000 | 3,212,000 | 0.47% | ||
| 26 | JPMORGAN CHASE & CO | 96,004 | 3,083,000 | 0.46% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 92,083 | 2,957,000 | 0.44% | ||
| 28 | Candriam S.C.A. | 80,000 | 2,569,000 | 0.38% | ||
| 29 | Bank of New York Mellon Corp | 72,232 | 2,319,000 | 0.34% | ||
| 30 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 70,680 | 2,270,000 | 0.34% | ||
| 31 | Polar Capital LLP | 70,182 | 2,254,000 | 0.33% | ||
| 32 | BALYASNY ASSET MANAGEMENT L.P. | 63,640 | 2,044,000 | 0.30% | ||
| 33 | RUSSELL INVESTMENTS GROUP, LTD. | 54,430 | 1,812,000 | 0.27% | ||
| 34 | BlackRock Investment Management, LLC | 54,984 | 1,766,000 | 0.26% | ||
| 35 | TEACHER RETIREMENT SYSTEM OF TEXAS | 54,261 | 1,743,000 | 0.26% | ||
| 36 | CRAWFORD LAKE CAPITAL MANAGEMENT, LLC | 52,713 | 1,693,000 | 0.25% | ||
| 37 | D. E. Shaw & Co., Inc. | 47,176 | 1,515,000 | 0.22% | ||
| 38 | SCHONFELD STRATEGIC ADVISORS LLC | 46,900 | 1,506,000 | 0.22% | ||
| 39 | MORGAN STANLEY | 44,353 | 1,424,000 | 0.21% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 43,359 | 1,393,000 | 0.21% | ||
| 41 | CREDIT SUISSE AG/ | 42,156 | 1,353,000 | 0.20% | ||
| 42 | GOLDMAN SACHS GROUP INC | 42,133 | 1,353,000 | 0.20% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 37,158 | 1,193,000 | 0.18% | ||
| 44 | AMERIPRISE FINANCIAL INC | 34,940 | 1,122,000 | 0.17% | ||
| 45 | STRS OHIO | 34,566 | 1,110,000 | 0.16% | ||
| 46 | Invesco Ltd. | 28,269 | 908,000 | 0.13% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,464 | 882,000 | 0.13% | ||
| 48 | TEACHERS ADVISORS, LLC | 22,139 | 711,000 | 0.11% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 21,623 | 694,000 | 0.10% | ||
| 50 | ALPS ADVISORS INC | 20,830 | 669,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
