| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Aisling Capital LLC | 3,796,362 | 108,006,000 | 21.51% | ||
| 2 | FMR LLC | 2,934,365 | 83,482,000 | 16.63% | ||
| 3 | ORBIMED ADVISORS LLC | 2,175,857 | 61,903,000 | 12.33% | ||
| 4 | NEA Management Company, LLC | 1,792,207 | 50,988,000 | 10.15% | ||
| 5 | RS INVESTMENT MANAGEMENT CO LLC | 1,444,626 | 41,100,000 | 8.19% | ||
| 6 | BVF INC/IL | 711,067 | 20,230,000 | 4.03% | ||
| 7 | EVENTIDE ASSET MANAGEMENT, LLC | 553,300 | 15,741,000 | 3.14% | ||
| 8 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 14,225,000 | 2.83% | ||
| 9 | Visium Asset Management, LP | 400,000 | 11,380,000 | 2.27% | ||
| 10 | DRIEHAUS CAPITAL MANAGEMENT LLC | 353,098 | 10,046,000 | 2.00% | ||
| 11 | AXA S.A. | 275,480 | 7,837,000 | 1.56% | ||
| 12 | VANGUARD GROUP INC | 252,585 | 7,186,000 | 1.43% | ||
| 13 | CASDIN CAPITAL, LLC | 251,500 | 7,155,000 | 1.43% | ||
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 251,000 | 7,141,000 | 1.42% | ||
| 15 | BlackRock Fund Advisors | 237,779 | 6,765,000 | 1.35% | ||
| 16 | BAKER BROS. ADVISORS LP | 137,735 | 3,919,000 | 0.78% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 126,753 | 3,606,000 | 0.72% | ||
| 18 | STATE STREET CORP | 123,932 | 3,530,000 | 0.70% | ||
| 19 | Informed Momentum Co LLC | 109,855 | 3,125,000 | 0.62% | ||
| 20 | AWM Investment Company, Inc. | 105,000 | 2,987,000 | 0.59% | ||
| 21 | NORTHERN TRUST CORP | 89,550 | 2,548,000 | 0.51% | ||
| 22 | Invesco Ltd. | 84,143 | 2,394,000 | 0.48% | ||
| 23 | PAULSON & CO. INC. | 82,179 | 2,338,000 | 0.47% | ||
| 24 | DAFNA Capital Management LLC | 61,737 | 1,756,000 | 0.35% | ||
| 25 | Opus Point Partners Management, LLC | 60,000 | 1,707,000 | 0.34% | ||
| 26 | Nicholas Investment Partners, LP | 56,553 | 1,609,000 | 0.32% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 54,942 | 1,563,000 | 0.31% | ||
| 28 | SPHERA FUNDS MANAGEMENT LTD. | 45,000 | 1,280,000 | 0.25% | ||
| 29 | Bank of New York Mellon Corp | 39,891 | 1,135,000 | 0.23% | ||
| 30 | GSA CAPITAL PARTNERS LLP | 37,100 | 1,055,000 | 0.21% | ||
| 31 | BlackRock Investment Management, LLC | 31,629 | 900,000 | 0.18% | ||
| 32 | DEUTSCHE BANK AG\ | 30,766 | 873,000 | 0.17% | ||
| 33 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 30,200 | 859,000 | 0.17% | ||
| 34 | BALYASNY ASSET MANAGEMENT L.P. | 27,550 | 784,000 | 0.16% | ||
| 35 | RUSSELL FRANK CO/ | 26,220 | 766,000 | 0.15% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 26,593 | 757,000 | 0.15% | ||
| 37 | CITADEL ADVISORS LLC | 25,501 | 726,000 | 0.14% | ||
| 38 | ALPS ADVISORS INC | 25,276 | 719,000 | 0.14% | ||
| 39 | BLACKROCK ADVISORS LLC | 21,391 | 609,000 | 0.12% | ||
| 40 | RENAISSANCE TECHNOLOGIES LLC | 20,800 | 592,000 | 0.12% | ||
| 41 | TWO SIGMA INVESTMENTS, LP | 20,324 | 578,000 | 0.12% | ||
| 42 | Spark Investment Management LLC | 18,800 | 534,000 | 0.11% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,864 | 480,000 | 0.10% | ||
| 44 | MORGAN STANLEY | 16,677 | 475,000 | 0.09% | ||
| 45 | PDT Partners, LLC | 14,831 | 422,000 | 0.08% | ||
| 46 | A.R.T. Advisors, LLC | 14,794 | 420,000 | 0.08% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 14,100 | 401,000 | 0.08% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,200 | 376,000 | 0.07% | ||
| 49 | TEACHERS ADVISORS, LLC | 11,552 | 329,000 | 0.07% | ||
| 50 | AQR CAPITAL MANAGEMENT LLC | 11,216 | 319,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
