| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | JENNISON ASSOCIATES LLC | 2,585,047 | 12,925,000 | 28.69% | ||
| 2 | ORBIMED ADVISORS LLC | 2,305,446 | 11,527,000 | 25.59% | ||
| 3 | Redmile Group, LLC | 1,553,225 | 7,766,000 | 17.24% | ||
| 4 | Clearbridge Investments, LLC | 499,476 | 2,497,000 | 5.54% | ||
| 5 | Artal Group S.A. | 400,000 | 2,000,000 | 4.44% | ||
| 6 | JANUS HENDERSON INVESTORS US LLC | 383,821 | 1,919,000 | 4.26% | ||
| 7 | SPHERA FUNDS MANAGEMENT LTD. | 330,000 | 1,650,000 | 3.66% | ||
| 8 | FRANKLIN RESOURCES INC | 309,700 | 1,549,000 | 3.44% | ||
| 9 | FMR LLC | 237,916 | 1,190,000 | 2.64% | ||
| 10 | ALTRINSIC GLOBAL ADVISORS LLC | 191,360 | 957,000 | 2.12% | ||
| 11 | PRINCIPAL FINANCIAL GROUP INC | 76,494 | 382,000 | 0.85% | ||
| 12 | MORGAN STANLEY | 48,553 | 243,000 | 0.54% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 29,444 | 147,000 | 0.33% | ||
| 14 | Hikari Power Ltd | 24,144 | 121,000 | 0.27% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 11,588 | 57,000 | 0.13% | ||
| 16 | WELLS FARGO & COMPANY/MN | 10,826 | 54,000 | 0.12% | ||
| 17 | Virtu KCG Holdings LLC | 10,367 | 52,000 | 0.12% | ||
| 18 | Creative Planning | 1,900 | 10,000 | 0.02% | ||
| 19 | ROYAL BANK OF CANADA | 523 | 3,000 | 0.01% | ||
| 20 | CRIBSTONE CAPITAL MANAGEMENT, LLC | 286 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
