| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 5,814,630 | 36,051,000 | 56.57% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 1,947,631 | 12,075,000 | 18.95% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 1,005,820 | 6,236,000 | 9.79% | ||
| 4 | Silver Rock Financial LLC | 419,320 | 2,600,000 | 4.08% | ||
| 5 | BAKER BROS. ADVISORS LP | 400,000 | 2,480,000 | 3.89% | ||
| 6 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 175,000 | 991,000 | 1.56% | ||
| 7 | NORGES BANK | 141,200 | 875,000 | 1.37% | ||
| 8 | PointState Capital LP | 124,339 | 771,000 | 1.21% | ||
| 9 | DAFNA Capital Management LLC | 120,000 | 744,000 | 1.17% | ||
| 10 | Alyeska Investment Group, L.P. | 57,926 | 359,000 | 0.56% | ||
| 11 | Polar Capital LLP | 36,963 | 229,000 | 0.36% | ||
| 12 | Spark Investment Management LLC | 23,400 | 144,000 | 0.23% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 14,699 | 91,000 | 0.14% | ||
| 14 | DEUTSCHE BANK AG\ | 10,729 | 66,000 | 0.10% | ||
| 15 | BlackRock Investment Management, LLC | 1,312 | 8,000 | 0.01% | ||
| 16 | MAGEE THOMSON INVESTMENT PARTNERS LLC | 514 | 4,000 | 0.01% | ||
| 17 | Tower Research Capital LLC (TRC) | 415 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
