| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 4,152,270 | 11,543,000 | 30.62% | ||
| 2 | ORBIMED ADVISORS LLC | 3,375,000 | 9,383,000 | 24.89% | ||
| 3 | Bain Capital Public Equity Management, LLC | 2,097,902 | 5,832,000 | 15.47% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 734,301 | 2,041,000 | 5.41% | ||
| 5 | BlackRock Fund Advisors | 468,237 | 1,302,000 | 3.45% | ||
| 6 | Opaleye Management Inc. | 430,000 | 1,195,000 | 3.17% | ||
| 7 | BAKER BROS. ADVISORS LP | 400,000 | 1,112,000 | 2.95% | ||
| 8 | Anson Funds Management LP | 363,161 | 1,010,000 | 2.68% | ||
| 9 | Lombard Odier Asset Management (USA) Corp | 350,989 | 976,000 | 2.59% | ||
| 10 | Tekla Capital Management LLC | 294,213 | 818,000 | 2.17% | ||
| 11 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 175,000 | 487,000 | 1.29% | ||
| 12 | MOORE CAPITAL MANAGEMENT, LP | 75,000 | 209,000 | 0.55% | ||
| 13 | RENAISSANCE TECHNOLOGIES LLC | 74,100 | 206,000 | 0.55% | ||
| 14 | MUHLENKAMP & CO INC | 73,109 | 203,000 | 0.54% | ||
| 15 | Telemetry Investments, L.L.C. | 69,347 | 193,000 | 0.51% | ||
| 16 | GOLDMAN SACHS GROUP INC | 53,748 | 149,000 | 0.40% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 51,999 | 145,000 | 0.38% | ||
| 18 | Virtu KCG Holdings LLC | 49,100 | 136,000 | 0.36% | ||
| 19 | MORGAN STANLEY | 47,953 | 133,000 | 0.35% | ||
| 20 | DEUTSCHE BANK AG\ | 24,420 | 67,000 | 0.18% | ||
| 21 | WELLS FARGO & COMPANY/MN | 22,749 | 63,000 | 0.17% | ||
| 22 | ProShare Advisors LLC | 20,977 | 58,000 | 0.15% | ||
| 23 | WEDBUSH SECURITIES INC | 20,743 | 58,000 | 0.15% | ||
| 24 | CREDIT SUISSE AG/ | 19,694 | 55,000 | 0.15% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,300 | 45,000 | 0.12% | Put | |
| 26 | BARCLAYS PLC | 14,741 | 41,000 | 0.11% | ||
| 27 | Creative Planning | 14,497 | 40,000 | 0.11% | ||
| 28 | Spark Investment Management LLC | 14,200 | 39,000 | 0.10% | ||
| 29 | SIMPLEX TRADING, LLC | 12,457 | 34,000 | 0.09% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 12,379 | 34,000 | 0.09% | ||
| 31 | D. E. Shaw & Co., Inc. | 10,986 | 31,000 | 0.08% | ||
| 32 | JPMORGAN CHASE & CO | 10,080 | 28,000 | 0.07% | ||
| 33 | CITIGROUP INC | 5,364 | 15,000 | 0.04% | ||
| 34 | UBS Group AG | 3,068 | 9,000 | 0.02% | ||
| 35 | ROYAL BANK OF CANADA | 742 | 2,000 | 0.01% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 110 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
