| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 5,814,630 | 36,632,000 | 60.64% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 1,893,351 | 11,928,000 | 19.74% | ||
| 3 | PERCEPTIVE ADVISORS LLC | 805,820 | 5,076,000 | 8.40% | ||
| 4 | BAKER BROS. ADVISORS LP | 400,000 | 2,520,000 | 4.17% | ||
| 5 | Silver Rock Financial LLC | 171,720 | 1,082,000 | 1.79% | ||
| 6 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 175,000 | 991,000 | 1.64% | ||
| 7 | NORGES BANK | 141,200 | 890,000 | 1.47% | ||
| 8 | Alyeska Investment Group, L.P. | 62,521 | 394,000 | 0.65% | ||
| 9 | DAFNA Capital Management LLC | 62,500 | 394,000 | 0.65% | SH | |
| 10 | Spark Investment Management LLC | 39,100 | 246,000 | 0.41% | ||
| 11 | ClariVest Asset Management LLC | 12,803 | 81,000 | 0.13% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 11,000 | 69,000 | 0.11% | ||
| 13 | BANK OF MONTREAL /CAN/ | 7,353 | 46,000 | 0.08% | ||
| 14 | ACADIAN ASSET MANAGEMENT LLC | 4,533 | 29,000 | 0.05% | ||
| 15 | Clearbridge Investments, LLC | 2,710 | 17,000 | 0.03% | ||
| 16 | BlackRock Investment Management, LLC | 1,312 | 8,000 | 0.01% | ||
| 17 | MAGEE THOMSON INVESTMENT PARTNERS LLC | 629 | 4,000 | 0.01% | ||
| 18 | UBS Group AG | 571 | 4,000 | 0.01% | ||
| 19 | Tower Research Capital LLC (TRC) | 284 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
