| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 5,814,630 | 78,323,000 | 36.89% | ||
| 2 | Bain Capital Public Equity Management, LLC | 2,097,902 | 28,259,000 | 13.31% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,647,973 | 22,198,000 | 10.45% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 1,023,820 | 13,791,000 | 6.49% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 946,810 | 12,753,000 | 6.01% | ||
| 6 | Lombard Odier Asset Management (USA) Corp | 650,000 | 8,755,000 | 4.12% | ||
| 7 | Opaleye Management Inc. | 590,300 | 7,951,000 | 3.74% | ||
| 8 | FMR LLC | 442,215 | 5,957,000 | 2.81% | ||
| 9 | BlackRock Fund Advisors | 402,515 | 5,422,000 | 2.55% | ||
| 10 | BAKER BROS. ADVISORS LP | 400,000 | 5,388,000 | 2.54% | ||
| 11 | TFS CAPITAL LLC | 201,988 | 2,721,000 | 1.28% | ||
| 12 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 175,000 | 2,357,000 | 1.11% | ||
| 13 | Numeric Investors LLC | 166,217 | 2,239,000 | 1.05% | ||
| 14 | Alyeska Investment Group, L.P. | 140,585 | 1,894,000 | 0.89% | ||
| 15 | STATE STREET CORP | 122,402 | 1,647,000 | 0.78% | ||
| 16 | NORGES BANK | 121,200 | 1,633,000 | 0.77% | ||
| 17 | Iguana Healthcare Management, LLC | 100,000 | 1,347,000 | 0.63% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 94,700 | 1,276,000 | 0.60% | ||
| 19 | Telemetry Investments, L.L.C. | 60,000 | 808,000 | 0.38% | ||
| 20 | Polar Capital LLP | 55,878 | 753,000 | 0.35% | ||
| 21 | BlackRock Investment Management, LLC | 53,872 | 726,000 | 0.34% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 44,438 | 599,000 | 0.28% | ||
| 23 | Bank of New York Mellon Corp | 42,354 | 570,000 | 0.27% | ||
| 24 | ACADIAN ASSET MANAGEMENT LLC | 31,189 | 421,000 | 0.20% | ||
| 25 | DAFNA Capital Management LLC | 28,950 | 390,000 | 0.18% | SH | |
| 26 | ALPS ADVISORS INC | 28,749 | 387,000 | 0.18% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,936 | 376,000 | 0.18% | ||
| 28 | VANGUARD GROUP INC | 27,108 | 365,000 | 0.17% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 23,095 | 311,000 | 0.15% | ||
| 30 | TEACHERS ADVISORS, LLC | 22,196 | 299,000 | 0.14% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,114 | 298,000 | 0.14% | ||
| 32 | CITADEL ADVISORS LLC | 20,585 | 277,000 | 0.13% | ||
| 33 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 15,000 | 202,000 | 0.10% | ||
| 34 | ClariVest Asset Management LLC | 12,803 | 172,000 | 0.08% | ||
| 35 | NORTHERN TRUST CORP | 12,524 | 169,000 | 0.08% | ||
| 36 | BANK OF MONTREAL /CAN/ | 12,133 | 163,000 | 0.08% | ||
| 37 | RHUMBLINE ADVISERS | 11,840 | 159,000 | 0.07% | ||
| 38 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,227 | 138,000 | 0.06% | ||
| 39 | Nationwide Fund Advisors | 9,835 | 132,000 | 0.06% | ||
| 40 | BARCLAYS PLC | 9,293 | 121,000 | 0.06% | ||
| 41 | AMERICAN INTERNATIONAL GROUP, INC. | 8,964 | 120,745 | 0.06% | ||
| 42 | NEW YORK STATE COMMON RETIREMENT FUND | 8,580 | 116,000 | 0.05% | ||
| 43 | BLACKROCK ADVISORS LLC | 7,693 | 104,000 | 0.05% | ||
| 44 | STRS OHIO | 4,900 | 66,000 | 0.03% | ||
| 45 | DEUTSCHE BANK AG\ | 3,675 | 49,000 | 0.02% | ||
| 46 | WELLS FARGO & COMPANY/MN | 2,416 | 32,000 | 0.02% | ||
| 47 | Clearbridge Investments, LLC | 2,210 | 30,000 | 0.01% | ||
| 48 | ROYAL BANK OF CANADA | 1,431 | 20,000 | 0.01% | ||
| 49 | BNP PARIBAS FINANCIAL MARKETS | 1,273 | 17,147 | 0.01% | ||
| 50 | UBS Group AG | 936 | 13,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
