| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 4,582,616 | 32,628,000 | 28.81% | ||
| 2 | Bain Capital Public Equity Management, LLC | 2,097,902 | 14,937,000 | 13.19% | ||
| 3 | FMR LLC | 1,426,173 | 10,154,000 | 8.97% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 1,056,110 | 7,519,000 | 6.64% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 868,820 | 6,186,000 | 5.46% | ||
| 6 | BlackRock Fund Advisors | 798,340 | 5,684,000 | 5.02% | ||
| 7 | Lombard Odier Asset Management (USA) Corp | 643,292 | 4,580,000 | 4.04% | ||
| 8 | PointState Capital LP | 608,233 | 4,331,000 | 3.82% | ||
| 9 | Opaleye Management Inc. | 595,000 | 4,236,000 | 3.74% | ||
| 10 | BAKER BROS. ADVISORS LP | 400,000 | 2,848,000 | 2.52% | ||
| 11 | Anson Funds Management LP | 373,344 | 2,658,000 | 2.35% | ||
| 12 | Tekla Capital Management LLC | 294,213 | 2,095,000 | 1.85% | ||
| 13 | TFS CAPITAL LLC | 224,347 | 1,597,000 | 1.41% | ||
| 14 | STATE STREET CORP | 205,171 | 1,460,000 | 1.29% | ||
| 15 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 175,000 | 1,246,000 | 1.10% | ||
| 16 | NORTHERN TRUST CORP | 134,269 | 956,000 | 0.84% | ||
| 17 | NORGES BANK | 120,487 | 858,000 | 0.76% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 107,198 | 763,000 | 0.67% | ||
| 19 | Telemetry Investments, L.L.C. | 100,000 | 712,000 | 0.63% | ||
| 20 | Jefferies Group LLC | 90,000 | 641,000 | 0.57% | ||
| 21 | GLG Partners LP | 59,403 | 423,000 | 0.37% | ||
| 22 | D. E. Shaw & Co., Inc. | 59,260 | 422,000 | 0.37% | ||
| 23 | SABBY MANAGEMENT, LLC | 56,773 | 404,000 | 0.36% | ||
| 24 | A.R.T. Advisors, LLC | 53,555 | 381,000 | 0.34% | ||
| 25 | BlackRock Investment Management, LLC | 53,231 | 379,000 | 0.33% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 49,177 | 350,000 | 0.31% | ||
| 27 | CITADEL ADVISORS LLC | 48,585 | 346,000 | 0.31% | ||
| 28 | VANGUARD GROUP INC | 43,383 | 309,000 | 0.27% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 42,170 | 300,000 | 0.26% | ||
| 30 | ALPS ADVISORS INC | 39,171 | 279,000 | 0.25% | ||
| 31 | Trexquant Investment LP | 36,900 | 263,000 | 0.23% | ||
| 32 | GOLDMAN SACHS GROUP INC | 31,286 | 223,000 | 0.20% | ||
| 33 | Bank of New York Mellon Corp | 30,734 | 219,000 | 0.19% | ||
| 34 | BANK OF NOVA SCOTIA | 30,725 | 218,000 | 0.19% | ||
| 35 | ProShare Advisors LLC | 28,975 | 206,000 | 0.18% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,337 | 202,000 | 0.18% | ||
| 37 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 28,000 | 199,000 | 0.18% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 27,348 | 194,000 | 0.17% | ||
| 39 | MUHLENKAMP & CO INC | 27,205 | 194,000 | 0.17% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,114 | 158,000 | 0.14% | ||
| 41 | TEACHERS ADVISORS, LLC | 22,196 | 158,000 | 0.14% | ||
| 42 | Virtu KCG Holdings LLC | 22,258 | 158,000 | 0.14% | ||
| 43 | AMERICAN INTERNATIONAL GROUP, INC. | 21,793 | 155,000 | 0.14% | ||
| 44 | PANAGORA ASSET MANAGEMENT INC | 21,188 | 151,000 | 0.13% | ||
| 45 | Creative Planning | 19,500 | 139,000 | 0.12% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 13,900 | 99,000 | 0.09% | ||
| 47 | RHUMBLINE ADVISERS | 13,809 | 98,000 | 0.09% | ||
| 48 | ELLINGTON MANAGEMENT GROUP LLC | 10,380 | 74,000 | 0.07% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,227 | 73,000 | 0.06% | ||
| 50 | Nationwide Fund Advisors | 9,835 | 70,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
