| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 4,126,493 | 10,234,000 | 28.96% | ||
| 2 | ORBIMED ADVISORS LLC | 3,775,000 | 9,362,000 | 26.49% | ||
| 3 | Bain Capital Public Equity Management, LLC | 2,097,902 | 5,203,000 | 14.72% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 734,301 | 1,821,000 | 5.15% | ||
| 5 | Opaleye Management Inc. | 595,000 | 1,476,000 | 4.18% | ||
| 6 | BlackRock Fund Advisors | 437,668 | 1,085,000 | 3.07% | ||
| 7 | BAKER BROS. ADVISORS LP | 400,000 | 992,000 | 2.81% | ||
| 8 | Lombard Odier Asset Management (USA) Corp | 365,677 | 907,000 | 2.57% | ||
| 9 | Anson Funds Management LP | 363,161 | 901,000 | 2.55% | ||
| 10 | Tekla Capital Management LLC | 294,213 | 730,000 | 2.07% | ||
| 11 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 175,000 | 434,000 | 1.23% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 107,800 | 267,000 | 0.76% | ||
| 13 | Telemetry Investments, L.L.C. | 100,000 | 248,000 | 0.70% | ||
| 14 | CREDIT SUISSE AG/ | 74,952 | 186,000 | 0.53% | ||
| 15 | MOORE CAPITAL MANAGEMENT, LP | 75,000 | 186,000 | 0.53% | ||
| 16 | DEUTSCHE BANK AG\ | 71,316 | 176,000 | 0.50% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 66,416 | 165,000 | 0.47% | ||
| 18 | GOLDMAN SACHS GROUP INC | 62,431 | 155,000 | 0.44% | ||
| 19 | Paloma Partners Management Co | 57,418 | 142,000 | 0.40% | ||
| 20 | MUHLENKAMP & CO INC | 29,154 | 72,000 | 0.20% | ||
| 21 | ProShare Advisors LLC | 24,756 | 61,000 | 0.17% | ||
| 22 | A.R.T. Advisors, LLC | 21,978 | 54,000 | 0.15% | ||
| 23 | Alpine Global Management, LLC | 20,745 | 51,000 | 0.14% | ||
| 24 | BARCLAYS PLC | 19,930 | 49,000 | 0.14% | ||
| 25 | LMR Partners LLP | 19,193 | 48,000 | 0.14% | ||
| 26 | NOMURA HOLDINGS INC | 18,000 | 44,000 | 0.12% | ||
| 27 | Squarepoint Ops LLC | 17,600 | 44,000 | 0.12% | ||
| 28 | Virtu KCG Holdings LLC | 15,204 | 38,000 | 0.11% | ||
| 29 | Creative Planning | 14,497 | 36,000 | 0.10% | ||
| 30 | WEDBUSH SECURITIES INC | 13,134 | 33,000 | 0.09% | ||
| 31 | JANE STREET GROUP, LLC | 13,442 | 33,000 | 0.09% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 12,273 | 30,000 | 0.08% | ||
| 33 | BANK OF AMERICA CORP /DE/ | 7,794 | 19,000 | 0.05% | ||
| 34 | MORGAN STANLEY | 6,786 | 17,000 | 0.05% | ||
| 35 | CITIGROUP INC | 4,167 | 10,000 | 0.03% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 4,200 | 10,000 | 0.03% | ||
| 37 | UBS Group AG | 2,824 | 7,000 | 0.02% | ||
| 38 | SEI INVESTMENTS CO | 2,000 | 5,000 | 0.01% | ||
| 39 | WOLVERINE TRADING LP /BD | 972 | 2,323 | 0.01% | ||
| 40 | Tower Research Capital LLC (TRC) | 400 | 1,000 | 0.00% | ||
| 41 | ROYAL BANK OF CANADA | 500 | 1,000 | 0.00% | ||
| 42 | ADVISOR GROUP, INC. | 519 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
