| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 4,582,616 | 28,275,000 | 27.17% | ||
| 2 | Bain Capital Public Equity Management, LLC | 2,097,902 | 12,944,000 | 12.44% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,620,607 | 9,999,000 | 9.61% | ||
| 4 | FMR LLC | 1,375,573 | 8,487,000 | 8.15% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 920,865 | 5,681,000 | 5.46% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 868,620 | 5,361,000 | 5.15% | ||
| 7 | PointState Capital LP | 850,000 | 5,245,000 | 5.04% | ||
| 8 | Lombard Odier Asset Management (USA) Corp | 637,615 | 3,934,000 | 3.78% | ||
| 9 | Opaleye Management Inc. | 590,300 | 3,642,000 | 3.50% | ||
| 10 | ALPS ADVISORS INC | 46,539 | 2,871,000 | 2.76% | ||
| 11 | BAKER BROS. ADVISORS LP | 400,000 | 2,468,000 | 2.37% | ||
| 12 | BlackRock Fund Advisors | 398,331 | 2,458,000 | 2.36% | ||
| 13 | Tekla Capital Management LLC | 228,083 | 1,407,000 | 1.35% | ||
| 14 | STATE STREET CORP | 200,731 | 1,239,000 | 1.19% | ||
| 15 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 175,000 | 1,080,000 | 1.04% | ||
| 16 | NORTHERN TRUST CORP | 134,064 | 827,000 | 0.79% | ||
| 17 | NORGES BANK | 120,487 | 743,000 | 0.71% | ||
| 18 | GLG Partners LP | 118,593 | 732,000 | 0.70% | ||
| 19 | Telemetry Investments, L.L.C. | 111,450 | 688,000 | 0.66% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 102,728 | 634,000 | 0.61% | ||
| 21 | TFS CAPITAL LLC | 102,470 | 632,000 | 0.61% | ||
| 22 | Numeric Investors LLC | 70,155 | 433,000 | 0.42% | ||
| 23 | Spark Investment Management LLC | 67,400 | 415,000 | 0.40% | ||
| 24 | SABBY MANAGEMENT, LLC | 56,773 | 350,000 | 0.34% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 54,074 | 334,000 | 0.32% | ||
| 26 | BlackRock Investment Management, LLC | 53,056 | 327,000 | 0.31% | ||
| 27 | Polar Capital LLP | 43,550 | 269,000 | 0.26% | ||
| 28 | ACADIAN ASSET MANAGEMENT LLC | 43,244 | 267,000 | 0.26% | ||
| 29 | VANGUARD GROUP INC | 39,655 | 244,000 | 0.23% | ||
| 30 | Bank of New York Mellon Corp | 30,734 | 189,000 | 0.18% | ||
| 31 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 28,000 | 173,000 | 0.17% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,836 | 172,000 | 0.17% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 26,064 | 160,000 | 0.15% | ||
| 34 | MUHLENKAMP & CO INC | 23,960 | 148,000 | 0.14% | ||
| 35 | TEACHERS ADVISORS, LLC | 22,196 | 137,000 | 0.13% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,114 | 137,000 | 0.13% | ||
| 37 | Creative Planning | 16,500 | 102,000 | 0.10% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 13,900 | 86,000 | 0.08% | ||
| 39 | CREDIT SUISSE AG/ | 13,672 | 84,000 | 0.08% | ||
| 40 | RHUMBLINE ADVISERS | 12,384 | 76,000 | 0.07% | ||
| 41 | GOLDMAN SACHS GROUP INC | 11,180 | 69,000 | 0.07% | ||
| 42 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,227 | 63,000 | 0.06% | ||
| 43 | Nationwide Fund Advisors | 9,835 | 61,000 | 0.06% | ||
| 44 | BANK OF MONTREAL /CAN/ | 9,280 | 57,000 | 0.05% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 8,974 | 55,000 | 0.05% | ||
| 46 | PANAGORA ASSET MANAGEMENT INC | 8,943 | 55,000 | 0.05% | ||
| 47 | BARCLAYS PLC | 9,080 | 54,000 | 0.05% | ||
| 48 | BLACKROCK ADVISORS LLC | 7,751 | 48,000 | 0.05% | ||
| 49 | DEUTSCHE BANK AG\ | 7,708 | 46,000 | 0.04% | ||
| 50 | MORGAN STANLEY | 5,303 | 33,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
