| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 24,940,961 | 104,004,000 | 16.46% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 11,911,502 | 49,671,000 | 7.86% | ||
| 3 | Invesco Ltd. | 8,423,615 | 35,126,000 | 5.56% | ||
| 4 | BlackRock Fund Advisors | 8,043,390 | 33,541,000 | 5.31% | ||
| 5 | BB BIOTECH AG | 7,500,000 | 31,275,000 | 4.95% | ||
| 6 | WELLS FARGO & COMPANY/MN | 7,300,918 | 30,446,000 | 4.82% | ||
| 7 | VANGUARD GROUP INC | 7,082,027 | 29,532,000 | 4.67% | ||
| 8 | STATE STREET CORP | 6,952,523 | 28,988,000 | 4.59% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 6,650,277 | 27,732,000 | 4.39% | ||
| 10 | RA CAPITAL MANAGEMENT, L.P. | 5,067,083 | 21,130,000 | 3.34% | ||
| 11 | Camber Capital Management LP | 4,750,000 | 19,807,000 | 3.14% | ||
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 4,037,354 | 16,836,000 | 2.67% | ||
| 13 | BNP Paribas Asset Management Holding S.A. | 3,840,274 | 16,014,000 | 2.53% | ||
| 14 | FRANKLIN RESOURCES INC | 3,613,265 | 15,067,000 | 2.39% | ||
| 15 | NORTHERN TRUST CORP | 2,735,577 | 11,408,000 | 1.81% | ||
| 16 | NORTHPOINTE CAPITAL LLC | 2,066,679 | 8,618,000 | 1.36% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 1,908,700 | 7,959,000 | 1.26% | ||
| 18 | AMERIPRISE FINANCIAL INC | 1,584,919 | 6,609,000 | 1.05% | ||
| 19 | CREDIT SUISSE AG/ | 1,504,262 | 6,273,000 | 0.99% | ||
| 20 | Cormorant Asset Management, LP | 1,500,000 | 6,255,000 | 0.99% | ||
| 21 | Bank of New York Mellon Corp | 1,404,926 | 5,859,000 | 0.93% | ||
| 22 | MORGAN STANLEY | 1,401,571 | 5,844,000 | 0.93% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 1,331,406 | 5,551,000 | 0.88% | ||
| 24 | BAKER BROS. ADVISORS LP | 1,223,362 | 5,101,000 | 0.81% | ||
| 25 | WILLIAM HARRIS INVESTORS INC | 1,108,377 | 4,622,000 | 0.73% | ||
| 26 | MCKINLEY CAPITAL MANAGEMENT LLC | 1,003,691 | 4,185,000 | 0.66% | ||
| 27 | CITY NATIONAL BANK | 993,244 | 4,142,000 | 0.66% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 854,426 | 3,563,000 | 0.56% | ||
| 29 | Catalyst Capital Advisors LLC | 836,000 | 3,487,000 | 0.55% | ||
| 30 | Nationwide Fund Advisors | 787,939 | 3,286,000 | 0.52% | ||
| 31 | STONERIDGE INVESTMENT PARTNERS LLC | 750,926 | 3,131,000 | 0.50% | ||
| 32 | Spot Trading L.L.C | 695,700 | 2,901,000 | 0.46% | Put | |
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 668,408 | 2,788,000 | 0.44% | ||
| 34 | BlackRock Investment Management, LLC | 650,872 | 2,714,000 | 0.43% | ||
| 35 | GUGGENHEIM CAPITAL LLC | 649,240 | 2,707,000 | 0.43% | ||
| 36 | HealthCor Management, L.P. | 590,000 | 2,460,000 | 0.39% | ||
| 37 | Rock Springs Capital Management LP | 575,000 | 2,398,000 | 0.38% | ||
| 38 | MARXE AUSTIN W & GREENHOUSE DAVID M | 570,000 | 2,377,000 | 0.38% | ||
| 39 | Employees Retirement System of Texas | 511,000 | 2,131,000 | 0.34% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 503,700 | 2,100,000 | 0.33% | ||
| 41 | First Eagle Investment Management, LLC | 500,000 | 2,085,000 | 0.33% | ||
| 42 | HARVEY CAPITAL MANAGEMENT INC | 494,950 | 2,063,000 | 0.33% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 464,300 | 1,936,000 | 0.31% | Put | |
| 44 | Informed Momentum Co LLC | 452,856 | 1,888,000 | 0.30% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 439,459 | 1,833,000 | 0.29% | ||
| 46 | D. E. Shaw & Co., Inc. | 406,306 | 1,694,000 | 0.27% | ||
| 47 | BANK OF MONTREAL /CAN/ | 400,000 | 1,668,000 | 0.26% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 393,700 | 1,642,000 | 0.26% | ||
| 49 | PANAGORA ASSET MANAGEMENT INC | 376,864 | 1,572,000 | 0.25% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 342,732 | 1,429,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
