| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 21,194,137 | 26,705,000 | 14.29% | ||
| 2 | VANGUARD GROUP INC | 20,742,737 | 26,136,000 | 13.98% | ||
| 3 | STATE STREET CORP | 19,971,040 | 25,163,000 | 13.46% | ||
| 4 | BlackRock Fund Advisors | 12,066,999 | 15,204,000 | 8.13% | ||
| 5 | BB BIOTECH AG | 8,330,000 | 10,496,000 | 5.62% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 7,613,524 | 9,593,000 | 5.13% | ||
| 7 | FRANKLIN RESOURCES INC | 5,483,365 | 6,909,000 | 3.70% | ||
| 8 | Quantitative Investment Management, LLC | 3,784,100 | 4,767,000 | 2.55% | ||
| 9 | MORGAN STANLEY | 3,359,928 | 4,233,000 | 2.26% | ||
| 10 | NORTHERN TRUST CORP | 3,249,426 | 4,095,000 | 2.19% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 3,135,072 | 3,950,000 | 2.11% | ||
| 12 | PANAGORA ASSET MANAGEMENT INC | 3,089,323 | 3,893,000 | 2.08% | ||
| 13 | NORGES BANK | 2,619,021 | 3,300,000 | 1.77% | ||
| 14 | JPMORGAN CHASE & CO | 2,612,717 | 3,292,000 | 1.76% | ||
| 15 | GEODE CAPITAL MANAGEMENT, LLC | 2,029,665 | 2,557,000 | 1.37% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 1,449,700 | 1,827,000 | 0.98% | ||
| 17 | D. E. Shaw & Co., Inc. | 1,350,606 | 1,702,000 | 0.91% | ||
| 18 | CITIGROUP INC | 1,312,547 | 1,653,000 | 0.88% | ||
| 19 | Bank of New York Mellon Corp | 1,204,753 | 1,517,000 | 0.81% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 1,052,857 | 1,327,000 | 0.71% | ||
| 21 | BlackRock Investment Management, LLC | 1,013,039 | 1,276,000 | 0.68% | ||
| 22 | CREDIT SUISSE AG/ | 991,924 | 1,250,000 | 0.67% | ||
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 952,449 | 1,201,000 | 0.64% | ||
| 24 | Rock Springs Capital Management LP | 820,000 | 1,033,000 | 0.55% | ||
| 25 | DEUTSCHE BANK AG\ | 758,724 | 954,000 | 0.51% | ||
| 26 | UBS Group AG | 719,601 | 906,000 | 0.48% | ||
| 27 | ALDEN GLOBAL CAPITAL LLC | 640,500 | 807,000 | 0.43% | ||
| 28 | Creative Planning | 606,715 | 764,000 | 0.41% | ||
| 29 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 591,900 | 746,000 | 0.40% | ||
| 30 | Tekla Capital Management LLC | 571,000 | 719,000 | 0.38% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 555,834 | 700,000 | 0.37% | ||
| 32 | ROYCE & ASSOCIATES LP | 550,000 | 693,000 | 0.37% | ||
| 33 | GROUP ONE TRADING LLC | 531,276 | 669,000 | 0.36% | ||
| 34 | Artal Group S.A. | 500,000 | 630,000 | 0.34% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 478,500 | 603,000 | 0.32% | Put | |
| 36 | Quantbot Technologies LP | 462,250 | 582,000 | 0.31% | ||
| 37 | TEACHERS ADVISORS, LLC | 455,686 | 574,000 | 0.31% | ||
| 38 | Swiss National Bank | 447,050 | 563,000 | 0.30% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 431,415 | 544,000 | 0.29% | ||
| 40 | FRONTIER CAPITAL MANAGEMENT CO LLC | 402,524 | 507,000 | 0.27% | ||
| 41 | GOLDMAN SACHS GROUP INC | 391,995 | 494,000 | 0.26% | ||
| 42 | WOLVERINE ASSET MANAGEMENT LLC | 381,100 | 480,000 | 0.26% | Put | |
| 43 | ALLIANCEBERNSTEIN L.P. | 363,701 | 458,000 | 0.25% | ||
| 44 | PERCEPTIVE ADVISORS LLC | 335,413 | 423,000 | 0.23% | ||
| 45 | WELLS FARGO & COMPANY/MN | 334,748 | 422,000 | 0.23% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 333,200 | 420,000 | 0.22% | ||
| 47 | BELLEVUE GROUP AG | 325,000 | 410,000 | 0.22% | ||
| 48 | BLACKROCK ADVISORS LLC | 323,973 | 408,000 | 0.22% | ||
| 49 | RHUMBLINE ADVISERS | 312,313 | 394,000 | 0.21% | ||
| 50 | CITADEL ADVISORS LLC | 293,900 | 370,000 | 0.20% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
