| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 40,545,355 | 294,765,000 | 18.19% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 23,483,121 | 170,722,000 | 10.53% | ||
| 3 | VANGUARD GROUP INC | 19,935,014 | 144,928,000 | 8.94% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 11,964,480 | 86,983,000 | 5.37% | ||
| 5 | BlackRock Fund Advisors | 10,155,357 | 73,829,000 | 4.56% | ||
| 6 | STATE STREET CORP | 9,014,643 | 65,542,000 | 4.04% | ||
| 7 | BB BIOTECH AG | 8,330,000 | 60,559,000 | 3.74% | ||
| 8 | Invesco Ltd. | 7,904,623 | 57,467,000 | 3.55% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 7,441,710 | 54,100,000 | 3.34% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 6,545,554 | 47,586,000 | 2.94% | ||
| 11 | FRANKLIN RESOURCES INC | 5,483,365 | 39,864,000 | 2.46% | ||
| 12 | FIRST TRUST ADVISORS LP | 5,248,180 | 38,154,000 | 2.35% | ||
| 13 | EAGLE ASSET MANAGEMENT INC | 5,032,209 | 36,584,000 | 2.26% | ||
| 14 | AMERIPRISE FINANCIAL INC | 3,951,960 | 28,726,000 | 1.77% | ||
| 15 | NORTHERN TRUST CORP | 3,337,308 | 24,263,000 | 1.50% | ||
| 16 | MORGAN STANLEY | 2,755,563 | 20,032,000 | 1.24% | ||
| 17 | BAKER BROS. ADVISORS LP | 2,379,254 | 17,297,000 | 1.07% | ||
| 18 | NORGES BANK | 2,248,096 | 16,344,000 | 1.01% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 2,179,700 | 15,846,000 | 0.98% | ||
| 20 | VOYA INVESTMENT MANAGEMENT LLC | 2,138,658 | 15,548,000 | 0.96% | ||
| 21 | NORTHPOINTE CAPITAL LLC | 2,124,035 | 15,442,000 | 0.95% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 2,035,254 | 14,796,000 | 0.91% | ||
| 23 | JPMORGAN CHASE & CO | 1,696,470 | 12,334,000 | 0.76% | ||
| 24 | Cormorant Asset Management, LP | 1,619,608 | 11,775,000 | 0.73% | ||
| 25 | EverPoint Asset Management, LLC | 1,600,000 | 11,632,000 | 0.72% | Put | |
| 26 | PANAGORA ASSET MANAGEMENT INC | 1,513,549 | 11,003,000 | 0.68% | ||
| 27 | DEUTSCHE BANK AG\ | 1,422,255 | 10,338,000 | 0.64% | ||
| 28 | Bank of New York Mellon Corp | 1,230,474 | 8,945,000 | 0.55% | ||
| 29 | BlackRock Investment Management, LLC | 1,005,689 | 7,311,000 | 0.45% | ||
| 30 | MCKINLEY CAPITAL MANAGEMENT LLC | 980,955 | 7,132,000 | 0.44% | ||
| 31 | CREDIT SUISSE AG/ | 962,615 | 6,997,000 | 0.43% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 959,708 | 6,978,000 | 0.43% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 959,220 | 6,974,000 | 0.43% | ||
| 34 | SECTORAL ASSET MANAGEMENT INC | 912,305 | 6,632,000 | 0.41% | ||
| 35 | Rock Springs Capital Management LP | 852,500 | 6,198,000 | 0.38% | ||
| 36 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 823,463 | 5,987,000 | 0.37% | ||
| 37 | D. E. Shaw & Co., Inc. | 770,658 | 5,603,000 | 0.35% | ||
| 38 | TEACHERS ADVISORS, LLC | 687,375 | 4,997,000 | 0.31% | ||
| 39 | WILLIAM HARRIS INVESTORS INC | 667,922 | 4,856,000 | 0.30% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 664,800 | 4,833,000 | 0.30% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 637,700 | 4,636,000 | 0.29% | Call | |
| 42 | Asset Management One Co., Ltd. | 646,515 | 4,635,000 | 0.29% | ||
| 43 | HARVEY CAPITAL MANAGEMENT INC | 602,750 | 4,381,000 | 0.27% | ||
| 44 | ALDEN GLOBAL CAPITAL LLC | 600,000 | 4,362,000 | 0.27% | ||
| 45 | Allianz Asset Management GmbH | 595,806 | 4,332,000 | 0.27% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 567,034 | 4,122,000 | 0.25% | ||
| 47 | TD ASSET MANAGEMENT INC | 566,100 | 4,116,000 | 0.25% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 554,060 | 4,028,000 | 0.25% | ||
| 49 | DAFNA Capital Management LLC | 550,000 | 3,999,000 | 0.25% | ||
| 50 | Creative Planning | 471,269 | 3,426,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
