| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 30,962,737 | 64,402,000 | 17.51% | ||
| 2 | VANGUARD GROUP INC | 20,215,812 | 42,048,000 | 11.43% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 14,821,308 | 30,828,000 | 8.38% | ||
| 4 | BlackRock Fund Advisors | 10,704,775 | 22,266,000 | 6.05% | ||
| 5 | STATE STREET CORP | 10,023,559 | 20,849,000 | 5.67% | ||
| 6 | BB BIOTECH AG | 8,330,000 | 17,326,000 | 4.71% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 6,709,352 | 13,955,000 | 3.79% | ||
| 8 | Invesco Ltd. | 6,184,315 | 12,863,000 | 3.50% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 5,528,297 | 11,499,000 | 3.13% | ||
| 10 | FRANKLIN RESOURCES INC | 5,483,365 | 11,405,000 | 3.10% | ||
| 11 | FIRST TRUST ADVISORS LP | 3,590,680 | 7,469,000 | 2.03% | ||
| 12 | JPMORGAN CHASE & CO | 3,570,243 | 7,427,000 | 2.02% | ||
| 13 | NORTHERN TRUST CORP | 3,270,835 | 6,803,000 | 1.85% | ||
| 14 | MORGAN STANLEY | 2,925,456 | 6,086,000 | 1.65% | ||
| 15 | NORGES BANK | 2,619,021 | 5,203,000 | 1.41% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 2,179,700 | 4,534,000 | 1.23% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 1,969,551 | 4,096,000 | 1.11% | ||
| 18 | PANAGORA ASSET MANAGEMENT INC | 1,775,110 | 3,692,000 | 1.00% | ||
| 19 | NORTHPOINTE CAPITAL LLC | 1,666,893 | 3,467,000 | 0.94% | ||
| 20 | Bank of New York Mellon Corp | 1,206,951 | 2,511,000 | 0.68% | ||
| 21 | CREDIT SUISSE AG/ | 1,162,873 | 2,419,000 | 0.66% | ||
| 22 | GROUP ONE TRADING LLC | 1,120,150 | 2,330,000 | 0.63% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,099,100 | 2,286,000 | 0.62% | Put | |
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,028,171 | 2,139,000 | 0.58% | ||
| 25 | BlackRock Investment Management, LLC | 1,014,536 | 2,110,000 | 0.57% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,007,264 | 2,096,000 | 0.57% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 959,133 | 1,995,000 | 0.54% | ||
| 28 | ROYCE & ASSOCIATES LP | 900,000 | 1,872,000 | 0.51% | ||
| 29 | Rock Springs Capital Management LP | 852,500 | 1,773,000 | 0.48% | ||
| 30 | OXFORD ASSET MANAGEMENT LLP | 668,498 | 1,390,000 | 0.38% | ||
| 31 | DEUTSCHE BANK AG\ | 630,747 | 1,311,000 | 0.36% | ||
| 32 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 622,200 | 1,294,000 | 0.35% | ||
| 33 | CITADEL ADVISORS LLC | 616,500 | 1,282,000 | 0.35% | Put | |
| 34 | CITADEL ADVISORS LLC | 578,140 | 1,203,000 | 0.33% | ||
| 35 | GOLDMAN SACHS GROUP INC | 574,413 | 1,195,000 | 0.32% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 571,434 | 1,189,000 | 0.32% | ||
| 37 | Tekla Capital Management LLC | 571,000 | 1,188,000 | 0.32% | ||
| 38 | Quantitative Investment Management, LLC | 557,700 | 1,160,000 | 0.32% | ||
| 39 | CITADEL ADVISORS LLC | 520,900 | 1,083,000 | 0.29% | Call | |
| 40 | Artal Group S.A. | 500,000 | 1,040,000 | 0.28% | ||
| 41 | BARCLAYS PLC | 493,200 | 1,026,000 | 0.28% | Call | |
| 42 | RTW INVESTMENTS, LP | 4,787 | 996,000 | 0.27% | Call | |
| 43 | WOLVERINE ASSET MANAGEMENT LLC | 456,800 | 950,000 | 0.26% | Put | |
| 44 | Swiss National Bank | 447,050 | 930,000 | 0.25% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 443,201 | 922,000 | 0.25% | ||
| 46 | TEACHERS ADVISORS, LLC | 437,167 | 909,000 | 0.25% | ||
| 47 | FRONTIER CAPITAL MANAGEMENT CO LLC | 428,998 | 892,000 | 0.24% | ||
| 48 | GUGGENHEIM CAPITAL LLC | 418,340 | 870,000 | 0.24% | ||
| 49 | BARCLAYS PLC | 417,700 | 869,000 | 0.24% | Put | |
| 50 | GREAT POINT PARTNERS LLC | 409,200 | 851,000 | 0.23% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
