| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 27,812,021 | 125,989,000 | 22.73% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 9,938,250 | 45,020,000 | 8.12% | ||
| 3 | BlackRock Fund Advisors | 7,763,431 | 35,168,000 | 6.35% | ||
| 4 | STATE STREET CORP | 6,391,887 | 28,955,000 | 5.22% | ||
| 5 | VANGUARD GROUP INC | 5,942,056 | 26,918,000 | 4.86% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 5,660,879 | 25,644,000 | 4.63% | ||
| 7 | Invesco Ltd. | 5,384,180 | 24,390,000 | 4.40% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 4,423,266 | 20,037,000 | 3.62% | ||
| 9 | FRANKLIN RESOURCES INC | 3,850,465 | 17,443,000 | 3.15% | ||
| 10 | WELLS FARGO & COMPANY/MN | 3,194,396 | 14,471,000 | 2.61% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,193,800 | 14,468,000 | 2.61% | ||
| 12 | NORTHERN TRUST CORP | 2,402,702 | 10,884,000 | 1.96% | ||
| 13 | Camber Capital Management LP | 2,250,000 | 10,192,000 | 1.84% | ||
| 14 | BNP Paribas Asset Management Holding S.A. | 2,148,910 | 9,735,000 | 1.76% | ||
| 15 | AMERIPRISE FINANCIAL INC | 1,833,896 | 8,307,000 | 1.50% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 1,740,900 | 7,886,000 | 1.42% | ||
| 17 | NORTHPOINTE CAPITAL LLC | 1,735,278 | 7,860,000 | 1.42% | ||
| 18 | Foresite Capital Management I, LLC | 1,336,200 | 6,053,000 | 1.09% | ||
| 19 | BAKER BROS. ADVISORS LP | 1,223,362 | 5,542,000 | 1.00% | ||
| 20 | Bank of New York Mellon Corp | 1,118,924 | 5,069,000 | 0.91% | ||
| 21 | HealthCor Management, L.P. | 1,116,236 | 5,057,000 | 0.91% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 1,036,729 | 4,696,000 | 0.85% | ||
| 23 | Cormorant Asset Management, LP | 1,000,000 | 4,530,000 | 0.82% | ||
| 24 | TIAA CREF INVESTMENT MANAGEMENT LLC | 734,078 | 3,325,000 | 0.60% | ||
| 25 | WILLIAM HARRIS INVESTORS INC | 720,000 | 3,262,000 | 0.59% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 611,401 | 2,770,000 | 0.50% | ||
| 27 | MARXE AUSTIN W & GREENHOUSE DAVID M | 570,000 | 2,582,000 | 0.47% | ||
| 28 | Informed Momentum Co LLC | 553,465 | 2,507,000 | 0.45% | ||
| 29 | GOLDMAN SACHS GROUP INC | 543,483 | 2,462,000 | 0.44% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 526,330 | 2,385,000 | 0.43% | ||
| 31 | BlackRock Investment Management, LLC | 515,902 | 2,337,000 | 0.42% | ||
| 32 | Employees Retirement System of Texas | 511,000 | 2,315,000 | 0.42% | ||
| 33 | CREDIT SUISSE AG/ | 507,969 | 2,301,000 | 0.42% | ||
| 34 | HARVEY CAPITAL MANAGEMENT INC | 506,950 | 2,296,000 | 0.41% | ||
| 35 | MORGAN STANLEY | 485,276 | 2,199,000 | 0.40% | ||
| 36 | CITY NATIONAL BANK | 462,537 | 2,095,000 | 0.38% | ||
| 37 | MCKINLEY CAPITAL MANAGEMENT LLC | 459,743 | 2,083,000 | 0.38% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 448,300 | 2,031,000 | 0.37% | Put | |
| 39 | Numeric Investors LLC | 447,200 | 2,026,000 | 0.37% | ||
| 40 | Nationwide Fund Advisors | 414,913 | 1,880,000 | 0.34% | ||
| 41 | D. E. Shaw & Co., Inc. | 403,452 | 1,828,000 | 0.33% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 393,700 | 1,700,000 | 0.31% | ||
| 43 | Connor, Clark & Lunn Investment Management Ltd. | 328,835 | 1,644,000 | 0.30% | ||
| 44 | RUSSELL FRANK CO/ | 356,821 | 1,616,000 | 0.29% | ||
| 45 | ProShare Advisors LLC | 348,090 | 1,577,000 | 0.28% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 346,182 | 1,568,000 | 0.28% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 337,566 | 1,529,000 | 0.28% | ||
| 48 | Rock Springs Capital Management LP | 325,000 | 1,472,000 | 0.27% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 320,454 | 1,452,000 | 0.26% | ||
| 50 | CITADEL ADVISORS LLC | 306,255 | 1,387,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
