| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 40,444,158 | 339,327,000 | 19.62% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 22,738,991 | 190,780,000 | 11.03% | ||
| 3 | VANGUARD GROUP INC | 18,017,812 | 151,169,000 | 8.74% | ||
| 4 | FIRST TRUST ADVISORS LP | 13,525,640 | 113,480,000 | 6.56% | ||
| 5 | BlackRock Fund Advisors | 9,978,226 | 83,717,000 | 4.84% | ||
| 6 | WELLINGTON MANAGEMENT GROUP LLP | 8,862,353 | 74,354,000 | 4.30% | ||
| 7 | STATE STREET CORP | 8,793,126 | 73,772,000 | 4.27% | ||
| 8 | BB BIOTECH AG | 8,330,000 | 69,889,000 | 4.04% | ||
| 9 | Invesco Ltd. | 8,143,484 | 68,324,000 | 3.95% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 6,589,958 | 55,290,000 | 3.20% | ||
| 11 | AMERIPRISE FINANCIAL INC | 3,332,153 | 27,956,000 | 1.62% | ||
| 12 | NORTHERN TRUST CORP | 3,241,949 | 27,200,000 | 1.57% | ||
| 13 | FRANKLIN RESOURCES INC | 3,042,865 | 25,530,000 | 1.48% | ||
| 14 | JANUS HENDERSON INVESTORS US LLC | 2,983,626 | 25,033,000 | 1.45% | ||
| 15 | CITADEL ADVISORS LLC | 2,301,386 | 19,308,000 | 1.12% | ||
| 16 | NORGES BANK | 2,248,096 | 18,862,000 | 1.09% | ||
| 17 | BAKER BROS. ADVISORS LP | 2,195,687 | 18,422,000 | 1.07% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 2,179,700 | 18,288,000 | 1.06% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 1,815,885 | 15,235,000 | 0.88% | ||
| 20 | EAGLE ASSET MANAGEMENT INC | 1,627,883 | 13,657,000 | 0.79% | ||
| 21 | Cormorant Asset Management, LP | 1,600,000 | 13,424,000 | 0.78% | ||
| 22 | VOYA INVESTMENT MANAGEMENT LLC | 1,490,081 | 12,502,000 | 0.72% | ||
| 23 | Bank of New York Mellon Corp | 1,250,892 | 10,494,000 | 0.61% | ||
| 24 | MORGAN STANLEY | 1,138,362 | 9,550,000 | 0.55% | ||
| 25 | BNP Paribas Asset Management Holding S.A. | 1,086,979 | 9,120,000 | 0.53% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 1,038,752 | 8,715,000 | 0.50% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 1,001,037 | 8,399,000 | 0.49% | ||
| 28 | CREDIT SUISSE AG/ | 945,215 | 7,931,000 | 0.46% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 899,193 | 7,545,000 | 0.44% | ||
| 30 | BlackRock Investment Management, LLC | 897,843 | 7,533,000 | 0.44% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 813,000 | 6,821,000 | 0.39% | ||
| 32 | DEUTSCHE BANK AG\ | 807,023 | 6,769,000 | 0.39% | ||
| 33 | Rock Springs Capital Management LP | 770,000 | 6,460,000 | 0.37% | ||
| 34 | FRED ALGER MANAGEMENT, LLC | 728,894 | 6,115,000 | 0.35% | ||
| 35 | TEACHERS ADVISORS, LLC | 649,828 | 5,452,000 | 0.32% | ||
| 36 | HARVEY CAPITAL MANAGEMENT INC | 645,650 | 5,417,000 | 0.31% | ||
| 37 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 626,146 | 5,254,000 | 0.30% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 591,113 | 4,959,000 | 0.29% | ||
| 39 | GUGGENHEIM CAPITAL LLC | 588,062 | 4,934,000 | 0.29% | ||
| 40 | TD ASSET MANAGEMENT INC | 576,800 | 4,839,000 | 0.28% | ||
| 41 | UBS Group AG | 507,707 | 4,260,000 | 0.25% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 496,682 | 4,167,000 | 0.24% | ||
| 43 | MCKINLEY CAPITAL MANAGEMENT LLC | 492,022 | 4,128,000 | 0.24% | ||
| 44 | WILLIAM HARRIS INVESTORS INC | 485,310 | 4,072,000 | 0.24% | ||
| 45 | GROUP ONE TRADING LLC | 460,601 | 3,864,000 | 0.22% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 452,569 | 3,797,000 | 0.22% | ||
| 47 | NORTHPOINTE CAPITAL LLC | 507,344 | 3,587,000 | 0.21% | ||
| 48 | Creative Planning | 425,250 | 3,568,000 | 0.21% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 401,900 | 3,372,000 | 0.19% | Put | |
| 50 | SPHERA FUNDS MANAGEMENT LTD. | 400,000 | 3,356,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
