| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 24,702,261 | 146,484,000 | 16.34% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 12,377,102 | 73,396,000 | 8.19% | ||
| 3 | Invesco Ltd. | 9,406,365 | 55,780,000 | 6.22% | ||
| 4 | BlackRock Fund Advisors | 8,912,279 | 52,850,000 | 5.90% | ||
| 5 | BB BIOTECH AG | 7,900,000 | 46,847,000 | 5.23% | ||
| 6 | VANGUARD GROUP INC | 7,355,595 | 43,619,000 | 4.87% | ||
| 7 | WELLS FARGO & COMPANY/MN | 7,092,511 | 42,058,000 | 4.69% | ||
| 8 | STATE STREET CORP | 6,617,020 | 39,240,000 | 4.38% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 6,512,387 | 38,618,000 | 4.31% | ||
| 10 | WELLINGTON MANAGEMENT GROUP LLP | 4,341,101 | 25,743,000 | 2.87% | ||
| 11 | BNP Paribas Asset Management Holding S.A. | 3,799,476 | 22,531,000 | 2.51% | ||
| 12 | FRANKLIN RESOURCES INC | 3,352,865 | 19,882,000 | 2.22% | ||
| 13 | RA CAPITAL MANAGEMENT, L.P. | 3,241,083 | 19,220,000 | 2.14% | ||
| 14 | NORTHERN TRUST CORP | 2,633,376 | 15,615,000 | 1.74% | ||
| 15 | NORTHPOINTE CAPITAL LLC | 2,259,077 | 13,396,000 | 1.49% | ||
| 16 | Camber Capital Management LP | 2,000,000 | 11,860,000 | 1.32% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 1,908,700 | 11,319,000 | 1.26% | ||
| 18 | Cormorant Asset Management, LP | 1,500,000 | 8,895,000 | 0.99% | ||
| 19 | CREDIT SUISSE AG/ | 1,488,344 | 8,825,000 | 0.98% | ||
| 20 | Bank of New York Mellon Corp | 1,404,827 | 8,331,000 | 0.93% | ||
| 21 | MORGAN STANLEY | 1,380,689 | 8,188,000 | 0.91% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 1,366,477 | 8,103,000 | 0.90% | ||
| 23 | AMERIPRISE FINANCIAL INC | 1,234,437 | 7,321,000 | 0.82% | ||
| 24 | BAKER BROS. ADVISORS LP | 1,223,362 | 7,255,000 | 0.81% | ||
| 25 | CITY NATIONAL BANK | 1,084,194 | 6,429,000 | 0.72% | ||
| 26 | MCKINLEY CAPITAL MANAGEMENT LLC | 997,636 | 5,916,000 | 0.66% | ||
| 27 | WILLIAM HARRIS INVESTORS INC | 995,427 | 5,903,000 | 0.66% | ||
| 28 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 947,341 | 5,617,732 | 0.63% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 944,738 | 5,602,000 | 0.62% | ||
| 30 | STONERIDGE INVESTMENT PARTNERS LLC | 908,534 | 5,388,000 | 0.60% | ||
| 31 | Catalyst Capital Advisors LLC | 846,000 | 5,017,000 | 0.56% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 812,794 | 4,820,000 | 0.54% | ||
| 33 | PRUDENTIAL FINANCIAL INC | 809,753 | 4,802,000 | 0.54% | ||
| 34 | Nationwide Fund Advisors | 776,396 | 4,604,000 | 0.51% | ||
| 35 | Informed Momentum Co LLC | 697,679 | 4,137,000 | 0.46% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 696,246 | 4,129,000 | 0.46% | ||
| 37 | GUGGENHEIM CAPITAL LLC | 669,474 | 3,970,000 | 0.44% | ||
| 38 | HealthCor Management, L.P. | 649,781 | 3,853,000 | 0.43% | ||
| 39 | BlackRock Investment Management, LLC | 647,726 | 3,841,000 | 0.43% | ||
| 40 | D. E. Shaw & Co., Inc. | 643,242 | 3,814,000 | 0.43% | ||
| 41 | Rock Springs Capital Management LP | 635,000 | 3,766,000 | 0.42% | ||
| 42 | PANAGORA ASSET MANAGEMENT INC | 624,290 | 3,702,000 | 0.41% | ||
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 602,700 | 3,574,000 | 0.40% | ||
| 44 | HARVEY CAPITAL MANAGEMENT INC | 594,650 | 3,526,000 | 0.39% | ||
| 45 | AWM Investment Company, Inc. | 570,000 | 3,380,000 | 0.38% | ||
| 46 | Employees Retirement System of Texas | 526,000 | 3,119,000 | 0.35% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 393,700 | 3,079,000 | 0.34% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 456,741 | 2,708,000 | 0.30% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 443,737 | 2,631,000 | 0.29% | ||
| 50 | RUSSELL FRANK CO/ | 369,615 | 2,151,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
