| 1 |
Canaan Partners VII LLC |
2,461,399 |
22,128,000 |
41.87% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
1,223,100 |
10,996,000 |
20.81% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
524,252 |
4,713,000 |
8.92% |
|
|
| 4 |
EMERALD ADVISERS, LLC |
387,134 |
3,372,000 |
6.38% |
|
|
| 5 |
PUTNAM INVESTMENTS LLC |
300,000 |
2,697,000 |
5.10% |
|
|
| 6 |
AWM Investment Company, Inc. |
267,337 |
2,403,000 |
4.55% |
|
|
| 7 |
SPHERA FUNDS MANAGEMENT LTD. |
213,533 |
1,920,000 |
3.63% |
|
|
| 8 |
BAKER BROS. ADVISORS LP |
200,000 |
1,798,000 |
3.40% |
|
|
| 9 |
EMERALD MUTUAL FUND ADVISERS TRUST |
162,903 |
1,419,000 |
2.69% |
|
|
| 10 |
ACUTA CAPITAL PARTNERS, LLC |
36,107 |
325,000 |
0.62% |
|
|
| 11 |
MORGAN STANLEY |
33,287 |
299,000 |
0.57% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
21,083 |
189,000 |
0.36% |
|
|
| 13 |
GOLDMAN SACHS GROUP INC |
16,677 |
150,000 |
0.28% |
|
|
| 14 |
Spark Investment Management LLC |
16,700 |
148,000 |
0.28% |
|
|
| 15 |
HARVEY CAPITAL MANAGEMENT INC |
15,000 |
134,000 |
0.25% |
|
|
| 16 |
Weiss Multi-Strategy Advisers LLC |
10,000 |
90,000 |
0.17% |
|
|
| 17 |
CAPITAL GUARDIAN TRUST CO |
4,120 |
37,000 |
0.07% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
1,587 |
14,000 |
0.03% |
|
|
| 19 |
BlackRock Investment Management, LLC |
986 |
9,000 |
0.02% |
|
|
| 20 |
Tower Research Capital LLC (TRC) |
300 |
3,000 |
0.01% |
|
|
| 21 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
162 |
1,000 |
0.00% |
|
|
