| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Canaan Partners VII LLC | 2,461,399 | 18,805,000 | 24.65% | ||
| 2 | FRANKLIN RESOURCES INC | 1,902,285 | 14,533,000 | 19.05% | ||
| 3 | ORBIMED ADVISORS LLC | 965,000 | 7,373,000 | 9.67% | ||
| 4 | ArrowMark Colorado Holdings LLC | 848,236 | 6,481,000 | 8.50% | ||
| 5 | New Leaf Venture Partners, L.L.C. | 704,572 | 5,383,000 | 7.06% | ||
| 6 | SPHERA FUNDS MANAGEMENT LTD. | 570,908 | 4,362,000 | 5.72% | ||
| 7 | DAFNA Capital Management LLC | 566,498 | 4,328,000 | 5.67% | ||
| 8 | EverPoint Asset Management, LLC | 325,000 | 2,483,000 | 3.26% | ||
| 9 | PUTNAM INVESTMENTS LLC | 300,000 | 2,292,000 | 3.00% | ||
| 10 | Point72 Asset Management, L.P. | 204,755 | 1,564,000 | 2.05% | ||
| 11 | BAKER BROS. ADVISORS LP | 200,000 | 1,528,000 | 2.00% | ||
| 12 | EMERALD ADVISERS, LLC | 193,228 | 1,476,000 | 1.94% | ||
| 13 | VANGUARD GROUP INC | 184,321 | 1,408,000 | 1.85% | ||
| 14 | Allianz Asset Management GmbH | 77,423 | 592,000 | 0.78% | ||
| 15 | Palo Alto Investors LP | 59,017 | 451,000 | 0.59% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 51,968 | 397,000 | 0.52% | ||
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,500 | 386,000 | 0.51% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 46,972 | 359,000 | 0.47% | ||
| 19 | CREDIT SUISSE AG/ | 36,695 | 280,000 | 0.37% | ||
| 20 | BLACKROCK ADVISORS LLC | 32,627 | 249,000 | 0.33% | ||
| 21 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 32,500 | 248,000 | 0.33% | ||
| 22 | NEXTHERA CAPITAL LP | 25,000 | 191,000 | 0.25% | ||
| 23 | A.R.T. Advisors, LLC | 24,969 | 190,000 | 0.25% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 21,180 | 162,000 | 0.21% | ||
| 25 | NORTHERN TRUST CORP | 18,920 | 145,000 | 0.19% | ||
| 26 | MENTA CAPITAL LLC | 14,612 | 112,000 | 0.15% | ||
| 27 | BlackRock Fund Advisors | 13,850 | 106,000 | 0.14% | ||
| 28 | HARVEY CAPITAL MANAGEMENT INC | 14,000 | 106,000 | 0.14% | ||
| 29 | BOOTHBAY FUND MANAGEMENT, LLC | 11,261 | 86,000 | 0.11% | ||
| 30 | TFS CAPITAL LLC | 10,147 | 78,000 | 0.10% | ||
| 31 | UBS Group AG | 5,160 | 39,000 | 0.05% | ||
| 32 | CAPITAL GUARDIAN TRUST CO | 4,120 | 31,000 | 0.04% | ||
| 33 | BlackRock Japan Co. Ltd | 2,516 | 19,000 | 0.02% | ||
| 34 | Walleye Trading LLC | 1,700 | 13,000 | 0.02% | ||
| 35 | DEUTSCHE BANK AG\ | 1,015 | 7,000 | 0.01% | ||
| 36 | BlackRock Investment Management, LLC | 875 | 7,000 | 0.01% | ||
| 37 | MORGAN STANLEY | 225 | 2,000 | 0.00% | ||
| 38 | WELLS FARGO & COMPANY/MN | 100 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
