| 1 |
Canaan Partners VII LLC |
2,461,399 |
13,242,000 |
25.22% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
2,182,185 |
11,740,000 |
22.36% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
965,000 |
5,192,000 |
9.89% |
|
|
| 4 |
ArrowMark Colorado Holdings LLC |
858,961 |
4,621,000 |
8.80% |
|
|
| 5 |
New Leaf Venture Partners, L.L.C. |
704,572 |
3,791,000 |
7.22% |
|
|
| 6 |
SPHERA FUNDS MANAGEMENT LTD. |
570,908 |
3,071,000 |
5.85% |
|
|
| 7 |
DAFNA Capital Management LLC |
566,498 |
3,048,000 |
5.80% |
|
|
| 8 |
EverPoint Asset Management, LLC |
325,000 |
1,749,000 |
3.33% |
|
|
| 9 |
PUTNAM INVESTMENTS LLC |
300,000 |
1,614,000 |
3.07% |
|
|
| 10 |
VANGUARD GROUP INC |
275,762 |
1,484,000 |
2.83% |
|
|
| 11 |
Allianz Asset Management GmbH |
73,234 |
394,000 |
0.75% |
|
|
| 12 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
69,100 |
372,000 |
0.71% |
|
|
| 13 |
Palo Alto Investors LP |
59,017 |
318,000 |
0.61% |
|
|
| 14 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
55,400 |
298,000 |
0.57% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
51,924 |
279,000 |
0.53% |
|
|
| 16 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
50,500 |
272,000 |
0.52% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
39,959 |
215,000 |
0.41% |
|
|
| 18 |
BLACKROCK ADVISORS LLC |
32,027 |
172,000 |
0.33% |
|
|
| 19 |
NORTHERN TRUST CORP |
21,108 |
114,000 |
0.22% |
|
|
| 20 |
BANK OF AMERICA CORP /DE/ |
21,180 |
114,000 |
0.22% |
|
|
| 21 |
UBS Group AG |
21,100 |
113,000 |
0.22% |
|
|
| 22 |
Bank of New York Mellon Corp |
16,535 |
89,000 |
0.17% |
|
|
| 23 |
BlackRock Fund Advisors |
13,232 |
71,000 |
0.14% |
|
|
| 24 |
HARVEY CAPITAL MANAGEMENT INC |
10,000 |
53,000 |
0.10% |
|
|
| 25 |
JPMORGAN CHASE & CO |
9,499 |
51,000 |
0.10% |
|
|
| 26 |
CAPITAL GUARDIAN TRUST CO |
4,120 |
22,000 |
0.04% |
|
|
| 27 |
BlackRock Investment Management, LLC |
1,045 |
6,000 |
0.01% |
|
|
| 28 |
Tower Research Capital LLC (TRC) |
904 |
5,000 |
0.01% |
|
|
| 29 |
WELLS FARGO & COMPANY/MN |
500 |
3,000 |
0.01% |
|
|
| 30 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
161 |
1,000 |
0.00% |
|
|
