| 1 |
Canaan Partners VII LLC |
2,461,399 |
3,126,000 |
27.66% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
2,182,185 |
2,771,000 |
24.52% |
|
|
| 3 |
SPHERA FUNDS MANAGEMENT LTD. |
1,170,643 |
1,487,000 |
13.16% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
867,600 |
1,102,000 |
9.75% |
|
|
| 5 |
ArrowMark Colorado Holdings LLC |
586,780 |
745,000 |
6.59% |
|
|
| 6 |
J. Goldman & Co LP |
547,290 |
695,000 |
6.15% |
|
|
| 7 |
PUTNAM INVESTMENTS LLC |
300,000 |
381,000 |
3.37% |
|
|
| 8 |
VANGUARD GROUP INC |
283,380 |
360,000 |
3.19% |
|
|
| 9 |
DAFNA Capital Management LLC |
90,237 |
115,000 |
1.02% |
|
|
| 10 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
75,500 |
96,000 |
0.85% |
|
|
| 11 |
Palo Alto Investors LP |
63,517 |
81,000 |
0.72% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
55,614 |
70,000 |
0.62% |
|
|
| 13 |
BlackRock Fund Advisors |
35,340 |
45,000 |
0.40% |
|
|
| 14 |
BLACKROCK ADVISORS LLC |
32,027 |
41,000 |
0.36% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
22,956 |
29,000 |
0.26% |
|
|
| 16 |
BANK OF AMERICA CORP /DE/ |
21,212 |
27,000 |
0.24% |
|
|
| 17 |
NORTHERN TRUST CORP |
21,108 |
27,000 |
0.24% |
|
|
| 18 |
UBS Group AG |
19,251 |
24,000 |
0.21% |
|
|
| 19 |
Bank of New York Mellon Corp |
16,474 |
21,000 |
0.19% |
|
|
| 20 |
GOLDMAN SACHS GROUP INC |
12,415 |
16,000 |
0.14% |
|
|
| 21 |
WEDBUSH SECURITIES INC |
11,000 |
14,000 |
0.12% |
|
|
| 22 |
Tower Research Capital LLC (TRC) |
8,260 |
10,000 |
0.09% |
|
|
| 23 |
Tradewinds Capital Management, LLC |
6,000 |
8,000 |
0.07% |
|
|
| 24 |
CAPITAL GUARDIAN TRUST CO |
4,120 |
5,000 |
0.04% |
|
|
| 25 |
BlackRock Investment Management, LLC |
2,024 |
3,000 |
0.03% |
|
|
| 26 |
WOLVERINE TRADING LP /BD |
1,312 |
1,719 |
0.02% |
|
|
| 27 |
MORGAN STANLEY |
1,200 |
1,000 |
0.01% |
|
|
| 28 |
WELLS FARGO & COMPANY/MN |
500 |
1,000 |
0.01% |
|
|
| 29 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
161 |
0 |
0.00% |
|
|
