| 1 |
Canaan Partners VII LLC |
2,461,399 |
20,528,000 |
38.31% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
1,090,585 |
9,095,000 |
16.97% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
704,572 |
5,876,000 |
10.97% |
|
|
| 4 |
PUTNAM INVESTMENTS LLC |
300,000 |
2,502,000 |
4.67% |
|
|
| 5 |
ArrowMark Colorado Holdings LLC |
272,701 |
2,274,000 |
4.24% |
|
|
| 6 |
Point72 Asset Management, L.P. |
231,895 |
1,934,000 |
3.61% |
|
|
| 7 |
BAKER BROS. ADVISORS LP |
200,000 |
1,668,000 |
3.11% |
|
|
| 8 |
EMERALD ADVISERS, LLC |
188,522 |
1,572,000 |
2.93% |
|
|
| 9 |
SPHERA FUNDS MANAGEMENT LTD. |
162,120 |
1,352,000 |
2.52% |
|
|
| 10 |
AWM Investment Company, Inc. |
122,500 |
1,022,000 |
1.91% |
|
|
| 11 |
CREDIT SUISSE AG/ |
99,015 |
826,000 |
1.54% |
|
|
| 12 |
GOLDMAN SACHS GROUP INC |
76,881 |
641,000 |
1.20% |
|
|
| 13 |
Iguana Healthcare Management, LLC |
75,000 |
626,000 |
1.17% |
|
|
| 14 |
MORGAN STANLEY |
68,229 |
569,000 |
1.06% |
|
|
| 15 |
Palo Alto Investors LP |
59,017 |
492,000 |
0.92% |
|
|
| 16 |
VANGUARD GROUP INC |
55,520 |
463,000 |
0.86% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
42,500 |
354,000 |
0.66% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
37,781 |
315,000 |
0.59% |
|
|
| 19 |
HARVEY CAPITAL MANAGEMENT INC |
25,500 |
212,000 |
0.40% |
|
|
| 20 |
TFS CAPITAL LLC |
24,538 |
205,000 |
0.38% |
|
|
| 21 |
Numeric Investors LLC |
23,629 |
197,000 |
0.37% |
|
|
| 22 |
DAFNA Capital Management LLC |
22,319 |
186,000 |
0.35% |
|
|
| 23 |
MENTA CAPITAL LLC |
20,558 |
171,000 |
0.32% |
|
|
| 24 |
A.R.T. Advisors, LLC |
20,323 |
169,000 |
0.32% |
|
|
| 25 |
BlackRock Fund Advisors |
12,218 |
102,000 |
0.19% |
|
|
| 26 |
PDT Partners, LLC |
11,800 |
98,000 |
0.18% |
|
|
| 27 |
BlackRock Institutional Trust Company, N.A. |
4,919 |
41,000 |
0.08% |
|
|
| 28 |
CAPITAL GUARDIAN TRUST CO |
4,120 |
34,000 |
0.06% |
|
|
| 29 |
Cubist Systematic Strategies, LLC |
2,093 |
17,000 |
0.03% |
|
|
| 30 |
Walleye Trading LLC |
1,700 |
14,000 |
0.03% |
|
|
| 31 |
MSI Financial Services Inc |
1,000 |
8,000 |
0.01% |
|
|
| 32 |
BlackRock Investment Management, LLC |
777 |
6,000 |
0.01% |
|
|
| 33 |
UBS Group AG |
649 |
5,000 |
0.01% |
|
|
| 34 |
PRELUDE CAPITAL MANAGEMENT, LLC |
400 |
3,000 |
0.01% |
|
|
| 35 |
Tower Research Capital LLC (TRC) |
200 |
2,000 |
0.00% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
100 |
1,000 |
0.00% |
|
|
| 37 |
CITIGROUP INC |
24 |
0 |
0.00% |
|
|
