| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 2,976,119 | 73,034,000 | 8.88% | ||
| 2 | ORBIMED ADVISORS LLC | 2,472,200 | 60,668,000 | 7.38% | ||
| 3 | Amici Capital, LLC | 1,979,550 | 48,578,000 | 5.91% | ||
| 4 | VANGUARD GROUP INC | 1,469,838 | 36,070,000 | 4.39% | ||
| 5 | STATE STREET CORP | 1,323,958 | 32,487,000 | 3.95% | ||
| 6 | CITADEL ADVISORS LLC | 1,175,799 | 28,854,000 | 3.51% | ||
| 7 | Polar Capital LLP | 1,080,944 | 26,525,000 | 3.23% | ||
| 8 | BlackRock Fund Advisors | 959,461 | 23,545,000 | 2.86% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 902,623 | 22,150,000 | 2.69% | ||
| 10 | WESTFIELD CAPITAL MANAGEMENT CO LP | 888,247 | 21,798,000 | 2.65% | ||
| 11 | Broadfin Capital, LLC | 789,710 | 19,379,000 | 2.36% | ||
| 12 | FRANKLIN RESOURCES INC | 772,930 | 18,968,000 | 2.31% | ||
| 13 | JHL Capital Group LLC | 754,195 | 18,508,000 | 2.25% | ||
| 14 | Redmile Group, LLC | 724,348 | 17,775,000 | 2.16% | ||
| 15 | New Leaf Venture Partners, L.L.C. | 712,498 | 17,485,000 | 2.13% | ||
| 16 | JENNISON ASSOCIATES LLC | 611,938 | 15,017,000 | 1.83% | ||
| 17 | Tourbillon Capital Partners, L.P. | 586,841 | 14,401,000 | 1.75% | ||
| 18 | Cormorant Asset Management, LP | 575,000 | 14,111,000 | 1.72% | ||
| 19 | AMERIPRISE FINANCIAL INC | 571,426 | 14,022,000 | 1.71% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 456,256 | 11,197,000 | 1.36% | ||
| 21 | GLENHILL ADVISORS LLC | 442,065 | 10,848,000 | 1.32% | ||
| 22 | CLOVIS CAPITAL MANAGEMENT LP | 425,000 | 10,430,000 | 1.27% | ||
| 23 | NORTHERN TRUST CORP | 408,040 | 10,014,000 | 1.22% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 388,610 | 9,537,000 | 1.16% | ||
| 25 | APEX CAPITAL, LLC | 380,000 | 9,325,000 | 1.13% | ||
| 26 | FMR LLC | 339,400 | 8,329,000 | 1.01% | ||
| 27 | Lombard Odier Asset Management (USA) Corp | 324,333 | 7,959,000 | 0.97% | ||
| 28 | ROYCE & ASSOCIATES LP | 319,000 | 7,828,000 | 0.95% | ||
| 29 | RENAISSANCE TECHNOLOGIES LLC | 302,551 | 7,425,000 | 0.90% | ||
| 30 | GOLDMAN SACHS GROUP INC | 300,000 | 7,362,000 | 0.90% | Call | |
| 31 | CLOUGH CAPITAL PARTNERS L P | 285,858 | 7,015,000 | 0.85% | ||
| 32 | EVENTIDE ASSET MANAGEMENT, LLC | 280,700 | 6,888,000 | 0.84% | ||
| 33 | Tekla Capital Management LLC | 275,000 | 6,749,000 | 0.82% | ||
| 34 | DEUTSCHE BANK AG\ | 253,062 | 6,209,000 | 0.76% | ||
| 35 | Pier Capital, LLC | 249,243 | 6,116,000 | 0.74% | ||
| 36 | Bank of New York Mellon Corp | 245,924 | 6,034,000 | 0.73% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 238,014 | 5,840,000 | 0.71% | ||
| 38 | LORD, ABBETT & CO. LLC | 224,763 | 5,515,000 | 0.67% | ||
| 39 | AXA S.A. | 215,794 | 5,296,000 | 0.64% | ||
| 40 | BLAIR WILLIAM & CO/IL | 191,915 | 4,709,000 | 0.57% | ||
| 41 | C WorldWide Group Holding A/S | 187,522 | 4,602,000 | 0.56% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 171,116 | 4,199,000 | 0.51% | ||
| 43 | PICTET ASSET MANAGEMENT LTD | 170,282 | 4,179,000 | 0.51% | ||
| 44 | Claar Advisors LLC | 166,100 | 4,076,000 | 0.50% | ||
| 45 | Informed Momentum Co LLC | 158,471 | 3,889,000 | 0.47% | ||
| 46 | OXFORD ASSET MANAGEMENT LLP | 158,033 | 3,878,000 | 0.47% | ||
| 47 | Nicholas Investment Partners, LP | 156,255 | 3,834,000 | 0.47% | ||
| 48 | DSC Advisors, L.P. | 155,000 | 3,804,000 | 0.46% | ||
| 49 | Invesco Ltd. | 150,810 | 3,701,000 | 0.45% | ||
| 50 | Rock Springs Capital Management LP | 150,000 | 3,681,000 | 0.45% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
