| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 2,959,800 | 43,154,000 | 8.66% | ||
| 2 | ORBIMED ADVISORS LLC | 2,403,300 | 35,040,000 | 7.04% | ||
| 3 | FMR LLC | 1,955,960 | 28,518,000 | 5.73% | ||
| 4 | STATE STREET CORP | 1,570,554 | 22,896,000 | 4.60% | ||
| 5 | VANGUARD GROUP INC | 1,521,695 | 22,187,000 | 4.45% | ||
| 6 | BANK OF AMERICA CORP /DE/ | 1,358,110 | 19,801,000 | 3.98% | ||
| 7 | GLENHILL ADVISORS LLC | 1,288,771 | 18,791,000 | 3.77% | ||
| 8 | Amici Capital, LLC | 1,016,002 | 14,813,000 | 2.97% | ||
| 9 | BlackRock Fund Advisors | 1,013,173 | 14,772,000 | 2.97% | ||
| 10 | Senvest Management, LLC | 997,731 | 14,547,000 | 2.92% | ||
| 11 | FRANKLIN RESOURCES INC | 978,730 | 14,270,000 | 2.87% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 942,830 | 13,746,000 | 2.76% | ||
| 13 | AMERIPRISE FINANCIAL INC | 854,561 | 12,458,000 | 2.50% | ||
| 14 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 845,300 | 12,324,000 | 2.47% | ||
| 15 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 800,000 | 11,664,000 | 2.34% | Call | |
| 16 | Cormorant Asset Management, LP | 635,000 | 9,258,000 | 1.86% | ||
| 17 | Broadfin Capital, LLC | 547,810 | 7,987,000 | 1.60% | ||
| 18 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 538,423 | 7,850,000 | 1.58% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 515,900 | 7,522,000 | 1.51% | Call | |
| 20 | GOLDMAN SACHS GROUP INC | 480,802 | 7,010,000 | 1.41% | ||
| 21 | NORTHERN TRUST CORP | 468,166 | 6,826,000 | 1.37% | ||
| 22 | New Leaf Venture Partners, L.L.C. | 454,881 | 6,632,000 | 1.33% | ||
| 23 | Point72 Asset Management, L.P. | 450,346 | 6,566,000 | 1.32% | ||
| 24 | CLOVIS CAPITAL MANAGEMENT LP | 416,397 | 6,071,000 | 1.22% | ||
| 25 | DEUTSCHE BANK AG\ | 391,982 | 5,713,000 | 1.15% | ||
| 26 | Polar Capital LLP | 379,932 | 5,539,000 | 1.11% | ||
| 27 | VIVO CAPITAL, LLC | 359,828 | 5,246,000 | 1.05% | ||
| 28 | Tekla Capital Management LLC | 345,050 | 5,031,000 | 1.01% | ||
| 29 | PANAGORA ASSET MANAGEMENT INC | 340,600 | 4,966,000 | 1.00% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 331,400 | 4,832,000 | 0.97% | Put | |
| 31 | BLAIR WILLIAM & CO/IL | 377,772 | 4,607,000 | 0.92% | ||
| 32 | SABBY MANAGEMENT, LLC | 290,505 | 4,236,000 | 0.85% | ||
| 33 | MORGAN STANLEY | 290,285 | 4,233,000 | 0.85% | ||
| 34 | PICTET ASSET MANAGEMENT LTD | 246,492 | 4,089,000 | 0.82% | ||
| 35 | AXA S.A. | 276,120 | 4,026,000 | 0.81% | ||
| 36 | LORD, ABBETT & CO. LLC | 273,362 | 3,985,000 | 0.80% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 260,091 | 3,792,000 | 0.76% | ||
| 38 | EVENTIDE ASSET MANAGEMENT, LLC | 250,000 | 3,645,000 | 0.73% | ||
| 39 | Lombard Odier Asset Management (USA) Corp | 245,728 | 3,583,000 | 0.72% | ||
| 40 | CLOUGH CAPITAL PARTNERS L P | 243,884 | 3,556,000 | 0.71% | ||
| 41 | C WorldWide Group Holding A/S | 189,962 | 2,770,000 | 0.56% | ||
| 42 | Bank of New York Mellon Corp | 187,933 | 2,740,000 | 0.55% | ||
| 43 | PUTNAM INVESTMENTS LLC | 175,729 | 2,563,000 | 0.51% | ||
| 44 | PAULSON & CO. INC. | 174,000 | 2,537,000 | 0.51% | ||
| 45 | Rock Springs Capital Management LP | 165,000 | 2,406,000 | 0.48% | ||
| 46 | ROYCE & ASSOCIATES LP | 164,000 | 2,391,000 | 0.48% | ||
| 47 | GW&K Investment Management, LLC | 160,213 | 2,336,000 | 0.47% | ||
| 48 | DSC Advisors, L.P. | 155,000 | 2,260,000 | 0.45% | ||
| 49 | Rhenman & Partners Asset Management AB | 150,000 | 2,187,000 | 0.44% | ||
| 50 | BlackRock Investment Management, LLC | 147,646 | 2,153,000 | 0.43% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
