| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 2,873,659 | 67,315,000 | 10.46% | ||
| 2 | Amici Capital, LLC | 2,567,830 | 60,151,000 | 9.35% | ||
| 3 | STATE STREET CORP | 1,674,364 | 39,219,000 | 6.10% | ||
| 4 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,443,447 | 33,813,000 | 5.26% | ||
| 5 | VANGUARD GROUP INC | 1,180,376 | 27,651,000 | 4.30% | ||
| 6 | Polar Capital LLP | 1,119,533 | 26,224,000 | 4.08% | ||
| 7 | Tourbillon Capital Partners, L.P. | 900,000 | 21,083,000 | 3.28% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 828,403 | 19,405,000 | 3.02% | ||
| 9 | FRANKLIN RESOURCES INC | 786,630 | 18,427,000 | 2.86% | ||
| 10 | BlackRock Fund Advisors | 774,887 | 18,152,000 | 2.82% | ||
| 11 | RA CAPITAL MANAGEMENT, L.P. | 766,000 | 17,944,000 | 2.79% | ||
| 12 | Broadfin Capital, LLC | 766,010 | 17,944,000 | 2.79% | ||
| 13 | AMERIPRISE FINANCIAL INC | 648,913 | 15,199,000 | 2.36% | ||
| 14 | SAB CAPITAL MANAGEMENT LP | 618,607 | 14,491,000 | 2.25% | ||
| 15 | New Leaf Venture Partners, L.L.C. | 612,498 | 14,348,000 | 2.23% | ||
| 16 | CLOUGH CAPITAL PARTNERS L P | 523,908 | 12,273,000 | 1.91% | ||
| 17 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 512,341 | 12,002,000 | 1.87% | ||
| 18 | Cormorant Asset Management, LP | 500,000 | 11,713,000 | 1.82% | ||
| 19 | JHL Capital Group LLC | 500,000 | 11,713,000 | 1.82% | ||
| 20 | GLENHILL ADVISORS LLC | 424,907 | 9,953,000 | 1.55% | ||
| 21 | OXFORD ASSET MANAGEMENT LLP | 395,867 | 9,273,000 | 1.44% | ||
| 22 | CLOVIS CAPITAL MANAGEMENT LP | 350,000 | 8,199,000 | 1.27% | Call | |
| 23 | NORTHERN TRUST CORP | 322,744 | 7,560,000 | 1.18% | ||
| 24 | Lombard Odier Asset Management (USA) Corp | 300,000 | 7,027,000 | 1.09% | ||
| 25 | Claar Advisors LLC | 250,000 | 5,856,000 | 0.91% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 247,200 | 5,791,000 | 0.90% | Call | |
| 27 | Informed Momentum Co LLC | 242,886 | 5,690,000 | 0.88% | ||
| 28 | Bank of New York Mellon Corp | 233,018 | 5,458,000 | 0.85% | ||
| 29 | ROYCE & ASSOCIATES LP | 232,000 | 5,435,000 | 0.84% | ||
| 30 | APEX CAPITAL, LLC | 220,000 | 5,154,000 | 0.80% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 194,500 | 4,556,000 | 0.71% | ||
| 32 | BLAIR WILLIAM & CO/IL | 187,396 | 4,390,000 | 0.68% | ||
| 33 | MORGAN STANLEY | 184,247 | 4,316,000 | 0.67% | ||
| 34 | FMR LLC | 184,200 | 4,315,000 | 0.67% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 178,839 | 4,189,000 | 0.65% | ||
| 36 | DRIEHAUS CAPITAL MANAGEMENT LLC | 173,224 | 4,058,000 | 0.63% | ||
| 37 | CITADEL ADVISORS LLC | 166,318 | 3,896,000 | 0.61% | ||
| 38 | C WorldWide Group Holding A/S | 156,962 | 3,677,000 | 0.57% | ||
| 39 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 3,514,000 | 0.55% | ||
| 40 | BARCLAYS PLC | 129,899 | 2,988,000 | 0.46% | ||
| 41 | Rhenman & Partners Asset Management AB | 122,835 | 2,877,000 | 0.45% | ||
| 42 | KENNEDY CAPITAL MANAGEMENT LLC | 113,856 | 2,667,000 | 0.41% | ||
| 43 | PUTNAM INVESTMENTS LLC | 110,736 | 2,594,000 | 0.40% | ||
| 44 | BlackRock Investment Management, LLC | 104,195 | 2,441,000 | 0.38% | ||
| 45 | D. E. Shaw & Co., Inc. | 101,943 | 2,388,000 | 0.37% | ||
| 46 | DSC Advisors, L.P. | 100,000 | 2,343,000 | 0.36% | ||
| 47 | CLOVIS CAPITAL MANAGEMENT LP | 100,000 | 2,343,000 | 0.36% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 99,122 | 2,322,000 | 0.36% | ||
| 49 | Point72 Asset Management, L.P. | 98,800 | 2,314,000 | 0.36% | ||
| 50 | RUSSELL FRANK CO/ | 92,683 | 2,171,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
