| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 3,205,300 | 61,670,000 | 9.24% | ||
| 2 | FMR LLC | 2,278,760 | 43,843,000 | 6.57% | ||
| 3 | ORBIMED ADVISORS LLC | 1,974,700 | 37,993,000 | 5.69% | ||
| 4 | STATE STREET CORP | 1,665,452 | 32,038,000 | 4.80% | ||
| 5 | Amici Capital, LLC | 1,639,602 | 31,546,000 | 4.73% | ||
| 6 | VANGUARD GROUP INC | 1,487,861 | 28,626,000 | 4.29% | ||
| 7 | BANK OF AMERICA CORP /DE/ | 1,483,103 | 28,535,000 | 4.28% | ||
| 8 | GLENHILL ADVISORS LLC | 1,170,440 | 22,520,000 | 3.37% | ||
| 9 | FRANKLIN RESOURCES INC | 978,730 | 18,831,000 | 2.82% | ||
| 10 | Cormorant Asset Management, LP | 975,000 | 18,759,000 | 2.81% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 953,439 | 18,344,000 | 2.75% | ||
| 12 | BlackRock Fund Advisors | 950,782 | 18,293,000 | 2.74% | ||
| 13 | AMERIPRISE FINANCIAL INC | 865,148 | 16,643,000 | 2.49% | ||
| 14 | Point72 Asset Management, L.P. | 804,126 | 15,471,000 | 2.32% | ||
| 15 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 558,964 | 10,754,000 | 1.61% | ||
| 16 | Broadfin Capital, LLC | 547,810 | 10,540,000 | 1.58% | ||
| 17 | New Leaf Venture Partners, L.L.C. | 496,042 | 9,544,000 | 1.43% | ||
| 18 | NORTHERN TRUST CORP | 432,085 | 8,313,000 | 1.25% | ||
| 19 | GOLDMAN SACHS GROUP INC | 430,666 | 8,286,000 | 1.24% | ||
| 20 | Polar Capital LLP | 430,000 | 8,273,000 | 1.24% | ||
| 21 | CLOVIS CAPITAL MANAGEMENT LP | 426,245 | 8,201,000 | 1.23% | ||
| 22 | D. E. Shaw & Co., Inc. | 409,653 | 7,882,000 | 1.18% | ||
| 23 | CLOUGH CAPITAL PARTNERS L P | 403,483 | 7,763,000 | 1.16% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 370,800 | 7,134,000 | 1.07% | Put | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 367,500 | 7,071,000 | 1.06% | Call | |
| 26 | VIVO CAPITAL, LLC | 357,755 | 6,883,000 | 1.03% | ||
| 27 | BLAIR WILLIAM & CO/IL | 320,147 | 6,159,000 | 0.92% | ||
| 28 | Senvest Management, LLC | 317,917 | 6,117,000 | 0.92% | ||
| 29 | Amici Capital, LLC | 300,000 | 5,772,000 | 0.86% | Call | |
| 30 | PointState Capital LP | 300,000 | 5,772,000 | 0.86% | ||
| 31 | ROYCE & ASSOCIATES LP | 299,000 | 5,753,000 | 0.86% | ||
| 32 | AXA S.A. | 287,427 | 5,530,000 | 0.83% | ||
| 33 | CQS Cayman LP | 282,853 | 5,442,000 | 0.82% | ||
| 34 | PANAGORA ASSET MANAGEMENT INC | 272,501 | 5,243,000 | 0.79% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 256,150 | 4,928,000 | 0.74% | ||
| 36 | EVENTIDE ASSET MANAGEMENT, LLC | 250,000 | 4,810,000 | 0.72% | ||
| 37 | Tekla Capital Management LLC | 240,950 | 4,636,000 | 0.69% | ||
| 38 | DEUTSCHE BANK AG\ | 236,734 | 4,554,000 | 0.68% | ||
| 39 | SABBY MANAGEMENT, LLC | 220,000 | 4,233,000 | 0.63% | ||
| 40 | Lombard Odier Asset Management (USA) Corp | 214,090 | 4,119,000 | 0.62% | ||
| 41 | Bank of New York Mellon Corp | 200,066 | 3,849,000 | 0.58% | ||
| 42 | PAULSON & CO. INC. | 199,700 | 3,842,000 | 0.58% | ||
| 43 | LORD, ABBETT & CO. LLC | 196,615 | 3,782,000 | 0.57% | ||
| 44 | PICTET ASSET MANAGEMENT LTD | 221,212 | 3,566,000 | 0.53% | ||
| 45 | Rock Springs Capital Management LP | 165,000 | 3,175,000 | 0.48% | ||
| 46 | C WorldWide Group Holding A/S | 159,962 | 3,078,000 | 0.46% | ||
| 47 | DSC Advisors, L.P. | 155,000 | 2,982,000 | 0.45% | ||
| 48 | GAM Holding AG | 152,900 | 2,942,000 | 0.44% | ||
| 49 | DRIEHAUS CAPITAL MANAGEMENT LLC | 151,921 | 2,923,000 | 0.44% | ||
| 50 | Rhenman & Partners Asset Management AB | 150,000 | 2,886,000 | 0.43% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
