| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 2,977,629 | 71,940,000 | 8.95% | ||
| 2 | FMR LLC | 2,636,982 | 63,709,000 | 7.93% | ||
| 3 | ORBIMED ADVISORS LLC | 2,472,200 | 59,728,000 | 7.43% | ||
| 4 | Amici Capital, LLC | 1,880,225 | 45,426,000 | 5.65% | ||
| 5 | VANGUARD GROUP INC | 1,483,161 | 35,833,000 | 4.46% | ||
| 6 | STATE STREET CORP | 1,117,142 | 26,991,000 | 3.36% | ||
| 7 | Polar Capital LLP | 1,080,944 | 26,115,000 | 3.25% | ||
| 8 | BANK OF AMERICA CORP /DE/ | 1,044,126 | 25,227,000 | 3.14% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 1,004,449 | 24,267,000 | 3.02% | ||
| 10 | BlackRock Fund Advisors | 995,307 | 24,047,000 | 2.99% | ||
| 11 | FRANKLIN RESOURCES INC | 817,330 | 19,747,000 | 2.46% | ||
| 12 | Broadfin Capital, LLC | 629,710 | 15,214,000 | 1.89% | ||
| 13 | AMERIPRISE FINANCIAL INC | 602,000 | 14,544,000 | 1.81% | ||
| 14 | Cormorant Asset Management, LP | 575,000 | 13,892,000 | 1.73% | ||
| 15 | New Leaf Venture Partners, L.L.C. | 546,998 | 13,215,000 | 1.64% | ||
| 16 | Tourbillon Capital Partners, L.P. | 514,648 | 12,434,000 | 1.55% | ||
| 17 | GOLDMAN SACHS GROUP INC | 493,982 | 11,935,000 | 1.48% | ||
| 18 | GLENHILL ADVISORS LLC | 489,050 | 11,815,000 | 1.47% | ||
| 19 | NORTHERN TRUST CORP | 424,749 | 10,261,000 | 1.28% | ||
| 20 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 400,000 | 9,664,000 | 1.20% | Call | |
| 21 | DRIEHAUS CAPITAL MANAGEMENT LLC | 395,117 | 9,546,000 | 1.19% | ||
| 22 | CLOUGH CAPITAL PARTNERS L P | 362,383 | 8,755,000 | 1.09% | ||
| 23 | APEX CAPITAL, LLC | 340,000 | 8,214,000 | 1.02% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 325,600 | 7,866,000 | 0.98% | Call | |
| 25 | MILLENNIUM MANAGEMENT LLC | 310,400 | 7,499,000 | 0.93% | Call | |
| 26 | Tekla Capital Management LLC | 275,000 | 6,644,000 | 0.83% | ||
| 27 | EVENTIDE ASSET MANAGEMENT, LLC | 250,000 | 6,040,000 | 0.75% | ||
| 28 | OXFORD ASSET MANAGEMENT LLP | 246,171 | 5,965,000 | 0.74% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 245,955 | 5,942,000 | 0.74% | ||
| 30 | CITADEL ADVISORS LLC | 237,407 | 5,736,000 | 0.71% | ||
| 31 | CQS Cayman LP | 237,310 | 5,733,000 | 0.71% | ||
| 32 | LORD, ABBETT & CO. LLC | 235,268 | 5,685,000 | 0.71% | ||
| 33 | PICTET ASSET MANAGEMENT LTD | 216,871 | 5,240,000 | 0.65% | ||
| 34 | CLOVIS CAPITAL MANAGEMENT LP | 215,479 | 5,206,000 | 0.65% | ||
| 35 | AXA S.A. | 211,351 | 5,106,000 | 0.64% | ||
| 36 | ROYCE & ASSOCIATES LP | 209,000 | 5,049,000 | 0.63% | ||
| 37 | BLAIR WILLIAM & CO/IL | 207,068 | 5,002,000 | 0.62% | ||
| 38 | Bank of New York Mellon Corp | 206,225 | 4,982,000 | 0.62% | ||
| 39 | EverPoint Asset Management, LLC | 200,000 | 4,832,000 | 0.60% | Put | |
| 40 | Lombard Odier Asset Management (USA) Corp | 195,869 | 4,732,000 | 0.59% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 193,936 | 4,685,000 | 0.58% | ||
| 42 | DEUTSCHE BANK AG\ | 191,446 | 4,624,000 | 0.58% | ||
| 43 | C WorldWide Group Holding A/S | 184,362 | 4,454,000 | 0.55% | ||
| 44 | RENAISSANCE TECHNOLOGIES LLC | 174,473 | 4,215,000 | 0.52% | ||
| 45 | Invesco Ltd. | 160,536 | 3,879,000 | 0.48% | ||
| 46 | Informed Momentum Co LLC | 159,125 | 3,844,000 | 0.48% | ||
| 47 | DSC Advisors, L.P. | 155,000 | 3,745,000 | 0.47% | ||
| 48 | MOORE CAPITAL MANAGEMENT, LP | 155,000 | 3,745,000 | 0.47% | ||
| 49 | Rock Springs Capital Management LP | 150,000 | 3,624,000 | 0.45% | ||
| 50 | D. E. Shaw & Co., Inc. | 140,683 | 3,399,000 | 0.42% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
