| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FEDERATED HERMES, INC. | 2,959,800 | 31,048,000 | 8.23% | ||
| 2 | Point72 Asset Management, L.P. | 1,754,000 | 18,399,000 | 4.87% | ||
| 3 | BLAIR WILLIAM & CO/IL | 1,738,506 | 18,237,000 | 4.83% | ||
| 4 | FMR LLC | 1,620,235 | 16,996,000 | 4.50% | ||
| 5 | VANGUARD GROUP INC | 1,556,665 | 16,328,000 | 4.33% | ||
| 6 | STATE STREET CORP | 1,548,561 | 16,247,000 | 4.30% | ||
| 7 | Senvest Management, LLC | 1,436,016 | 15,064,000 | 3.99% | ||
| 8 | Broadfin Capital, LLC | 1,347,810 | 14,139,000 | 3.75% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,205,300 | 12,644,000 | 3.35% | Call | |
| 10 | BlackRock Fund Advisors | 1,075,267 | 11,280,000 | 2.99% | ||
| 11 | FRANKLIN RESOURCES INC | 978,730 | 10,267,000 | 2.72% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 955,946 | 10,028,000 | 2.66% | ||
| 13 | GLENHILL ADVISORS LLC | 911,326 | 9,561,000 | 2.53% | ||
| 14 | GOLDMAN SACHS GROUP INC | 883,756 | 9,271,000 | 2.46% | ||
| 15 | AMERIPRISE FINANCIAL INC | 837,048 | 8,778,000 | 2.33% | ||
| 16 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 808,703 | 8,483,000 | 2.25% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 763,800 | 8,012,000 | 2.12% | Call | |
| 18 | PERCEPTIVE ADVISORS LLC | 16,000 | 7,180,000 | 1.90% | Put | |
| 19 | PICTET ASSET MANAGEMENT LTD | 633,376 | 6,644,000 | 1.76% | ||
| 20 | MORGAN STANLEY | 604,358 | 6,340,000 | 1.68% | ||
| 21 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 571,555 | 5,996,000 | 1.59% | ||
| 22 | Amici Capital, LLC | 545,202 | 5,719,000 | 1.52% | ||
| 23 | SABBY MANAGEMENT, LLC | 521,875 | 5,474,000 | 1.45% | ||
| 24 | NORTHERN TRUST CORP | 469,186 | 4,922,000 | 1.30% | ||
| 25 | New Leaf Venture Partners, L.L.C. | 400,381 | 4,200,000 | 1.11% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 374,488 | 3,928,000 | 1.04% | ||
| 27 | VIVO CAPITAL, LLC | 359,828 | 3,775,000 | 1.00% | ||
| 28 | Tekla Capital Management LLC | 345,050 | 3,620,000 | 0.96% | ||
| 29 | DEUTSCHE BANK AG\ | 319,627 | 3,352,000 | 0.89% | ||
| 30 | CQS Cayman LP | 316,582 | 3,321,000 | 0.88% | ||
| 31 | PANAGORA ASSET MANAGEMENT INC | 301,033 | 3,158,000 | 0.84% | ||
| 32 | Rhenman & Partners Asset Management AB | 300,000 | 3,147,000 | 0.83% | ||
| 33 | C WorldWide Group Holding A/S | 297,462 | 3,120,000 | 0.83% | ||
| 34 | AXA S.A. | 276,212 | 2,897,000 | 0.77% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 263,527 | 2,764,000 | 0.73% | ||
| 36 | CITADEL ADVISORS LLC | 253,339 | 2,657,000 | 0.70% | ||
| 37 | Amici Capital, LLC | 2,501 | 2,624,000 | 0.70% | Put | |
| 38 | EVENTIDE ASSET MANAGEMENT, LLC | 250,000 | 2,623,000 | 0.69% | ||
| 39 | Ghost Tree Capital, LLC | 200,000 | 2,098,000 | 0.56% | Call | |
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 199,000 | 2,088,000 | 0.55% | Put | |
| 41 | PAULSON & CO. INC. | 174,000 | 1,825,000 | 0.48% | ||
| 42 | CLOVIS CAPITAL MANAGEMENT LP | 167,907 | 1,761,000 | 0.47% | ||
| 43 | Bank of New York Mellon Corp | 167,307 | 1,755,000 | 0.46% | ||
| 44 | Rock Springs Capital Management LP | 165,000 | 1,731,000 | 0.46% | ||
| 45 | DSC Advisors, L.P. | 155,000 | 1,626,000 | 0.43% | ||
| 46 | BlackRock Investment Management, LLC | 152,732 | 1,602,000 | 0.42% | ||
| 47 | UBS Group AG | 152,531 | 1,601,000 | 0.42% | ||
| 48 | Jefferies Group LLC | 150,900 | 1,583,000 | 0.42% | Call | |
| 49 | JPMORGAN CHASE & CO | 135,400 | 1,420,000 | 0.38% | ||
| 50 | EverPoint Asset Management, LLC | 130,000 | 1,364,000 | 0.36% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
