| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,411,021 | 62,132,000 | 17.92% | ||
| 2 | Omega Fund Management, LLC | 2,138,872 | 55,119,000 | 15.90% | ||
| 3 | BAUPOST GROUP LLC/MA | 1,544,498 | 39,802,000 | 11.48% | ||
| 4 | Abingworth LLP | 1,301,413 | 33,524,000 | 9.67% | ||
| 5 | Tekla Capital Management LLC | 691,000 | 17,807,000 | 5.14% | ||
| 6 | Aisling Capital LLC | 682,680 | 17,593,000 | 5.07% | ||
| 7 | Broadfin Capital, LLC | 530,283 | 13,665,000 | 3.94% | ||
| 8 | GREAT POINT PARTNERS LLC | 415,338 | 10,703,000 | 3.09% | ||
| 9 | BROWN BROTHERS HARRIMAN & CO | 367,902 | 9,481,000 | 2.73% | ||
| 10 | BlackRock Fund Advisors | 319,034 | 8,222,000 | 2.37% | ||
| 11 | VANGUARD GROUP INC | 310,402 | 7,999,000 | 2.31% | ||
| 12 | JENNISON ASSOCIATES LLC | 301,514 | 7,770,000 | 2.24% | ||
| 13 | GENERAL AMERICAN INVESTORS CO INC | 277,076 | 7,140,000 | 2.06% | ||
| 14 | Bank of New York Mellon Corp | 235,170 | 6,059,000 | 1.75% | ||
| 15 | JPMORGAN CHASE & CO | 216,902 | 5,590,000 | 1.61% | ||
| 16 | Roumell Asset Management, LLC | 207,703 | 5,353,000 | 1.54% | ||
| 17 | NEA Management Company, LLC | 173,892 | 4,481,000 | 1.29% | ||
| 18 | Granahan Investment Management, LLC | 141,376 | 3,643,000 | 1.05% | ||
| 19 | Omega Advisors Inc. | 140,300 | 3,616,000 | 1.04% | ||
| 20 | Lombard Odier Asset Management (USA) Corp | 140,000 | 3,607,000 | 1.04% | ||
| 21 | STATE STREET CORP | 105,534 | 2,718,000 | 0.78% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 104,086 | 2,682,000 | 0.77% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 88,708 | 2,286,000 | 0.66% | ||
| 24 | DEUTSCHE BANK AG\ | 65,414 | 1,684,000 | 0.49% | ||
| 25 | SABBY MANAGEMENT, LLC | 55,613 | 1,433,000 | 0.41% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 44,992 | 1,159,000 | 0.33% | ||
| 27 | BlackRock Investment Management, LLC | 42,385 | 1,092,000 | 0.31% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 40,355 | 1,040,000 | 0.30% | ||
| 29 | MILLENNIUM MANAGEMENT LLC | 38,286 | 987,000 | 0.28% | ||
| 30 | DIMENSIONAL FUND ADVISORS LP | 29,363 | 757,000 | 0.22% | ||
| 31 | TFS CAPITAL LLC | 23,960 | 617,000 | 0.18% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 22,269 | 574,000 | 0.17% | ||
| 33 | NORGES BANK | 21,313 | 549,000 | 0.16% | ||
| 34 | NORTHERN TRUST CORP | 18,826 | 486,000 | 0.14% | ||
| 35 | TEACHERS ADVISORS, LLC | 17,609 | 454,000 | 0.13% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,408 | 449,000 | 0.13% | ||
| 37 | PDT Partners, LLC | 16,600 | 428,000 | 0.12% | ||
| 38 | A.R.T. Advisors, LLC | 11,872 | 305,000 | 0.09% | ||
| 39 | BLACKROCK ADVISORS LLC | 11,658 | 300,000 | 0.09% | ||
| 40 | DRW Securities, LLC | 11,512 | 297,000 | 0.09% | ||
| 41 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 11,040 | 285,000 | 0.08% | ||
| 42 | APPLETON PARTNERS INC/MA | 10,043 | 259,000 | 0.07% | ||
| 43 | RHUMBLINE ADVISERS | 9,930 | 256,000 | 0.07% | ||
| 44 | METROPOLITAN LIFE INSURANCE CO/NY | 9,202 | 237,000 | 0.07% | ||
| 45 | PANAGORA ASSET MANAGEMENT INC | 8,495 | 219,000 | 0.06% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,276 | 213,000 | 0.06% | ||
| 47 | ANCHOR CAPITAL ADVISORS LLC | 8,000 | 206,000 | 0.06% | ||
| 48 | Nationwide Fund Advisors | 7,905 | 204,000 | 0.06% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 7,146 | 184,152 | 0.05% | ||
| 50 | NEW YORK STATE COMMON RETIREMENT FUND | 6,874 | 177,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
