| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,612,433 | 39,631,000 | 18.51% | ||
| 2 | Omega Fund Management, LLC | 2,138,872 | 32,447,000 | 15.16% | ||
| 3 | BAUPOST GROUP LLC/MA | 1,544,498 | 23,430,000 | 10.95% | ||
| 4 | Abingworth LLP | 1,301,413 | 19,703,000 | 9.20% | ||
| 5 | Tekla Capital Management LLC | 762,581 | 11,568,000 | 5.40% | ||
| 6 | Aisling Capital LLC | 682,680 | 10,356,000 | 4.84% | ||
| 7 | Broadfin Capital, LLC | 530,282 | 8,044,000 | 3.76% | ||
| 8 | Fortress Investment Group LLC | 433,804 | 6,581,000 | 3.07% | ||
| 9 | BROWN BROTHERS HARRIMAN & CO | 367,902 | 5,581,000 | 2.61% | ||
| 10 | VANGUARD GROUP INC | 364,043 | 5,523,000 | 2.58% | ||
| 11 | Granahan Investment Management, LLC | 321,270 | 4,874,000 | 2.28% | ||
| 12 | BlackRock Fund Advisors | 317,504 | 4,817,000 | 2.25% | ||
| 13 | GREAT POINT PARTNERS LLC | 305,459 | 4,634,000 | 2.16% | ||
| 14 | GENERAL AMERICAN INVESTORS CO INC | 277,076 | 4,203,000 | 1.96% | ||
| 15 | Rock Springs Capital Management LP | 223,000 | 3,383,000 | 1.58% | ||
| 16 | Roumell Asset Management, LLC | 217,128 | 3,294,000 | 1.54% | ||
| 17 | JPMORGAN CHASE & CO | 216,902 | 3,290,000 | 1.54% | ||
| 18 | SABBY MANAGEMENT, LLC | 192,322 | 2,918,000 | 1.36% | ||
| 19 | STATE STREET CORP | 160,205 | 2,432,000 | 1.14% | ||
| 20 | NORTHERN TRUST CORP | 137,871 | 2,092,000 | 0.98% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 129,733 | 1,968,000 | 0.92% | ||
| 22 | NEA Management Company, LLC | 125,004 | 1,896,000 | 0.89% | ||
| 23 | Lombard Odier Asset Management (USA) Corp | 89,531 | 1,358,000 | 0.63% | ||
| 24 | RENAISSANCE TECHNOLOGIES LLC | 78,564 | 1,192,000 | 0.56% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 50,943 | 772,000 | 0.36% | ||
| 26 | Opus Point Partners Management, LLC | 45,000 | 683,000 | 0.32% | ||
| 27 | TFS CAPITAL LLC | 44,891 | 681,000 | 0.32% | ||
| 28 | BlackRock Investment Management, LLC | 42,998 | 652,000 | 0.30% | ||
| 29 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 42,660 | 647,000 | 0.30% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 40,658 | 617,000 | 0.29% | ||
| 31 | Bank of New York Mellon Corp | 40,524 | 615,000 | 0.29% | ||
| 32 | DEUTSCHE BANK AG\ | 28,340 | 429,000 | 0.20% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,836 | 392,000 | 0.18% | ||
| 34 | LPL Financial LLC | 26,000 | 388,000 | 0.18% | ||
| 35 | NORGES BANK | 21,313 | 323,000 | 0.15% | ||
| 36 | TEACHERS ADVISORS, LLC | 17,609 | 267,000 | 0.12% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,408 | 265,000 | 0.12% | ||
| 38 | VIRTUS ETF ADVISERS LLC | 14,884 | 226,000 | 0.11% | ||
| 39 | Swiss National Bank | 15,400 | 224,000 | 0.10% | ||
| 40 | RHUMBLINE ADVISERS | 12,282 | 186,000 | 0.09% | ||
| 41 | NEW YORK STATE COMMON RETIREMENT FUND | 11,700 | 177,000 | 0.08% | ||
| 42 | LOEB PARTNERS CORP | 10,000 | 152,000 | 0.07% | ||
| 43 | Weiss Multi-Strategy Advisers LLC | 10,000 | 152,000 | 0.07% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,913 | 143,000 | 0.07% | ||
| 45 | METROPOLITAN LIFE INSURANCE CO/NY | 9,202 | 140,000 | 0.07% | ||
| 46 | CITIGROUP INC | 8,525 | 129,000 | 0.06% | ||
| 47 | Nationwide Fund Advisors | 8,303 | 126,000 | 0.06% | ||
| 48 | AMERICAN INTERNATIONAL GROUP, INC. | 7,141 | 108,000 | 0.05% | ||
| 49 | INTEGRATED WEALTH MANAGEMENT | 4,500 | 68,000 | 0.03% | ||
| 50 | BLACKROCK ADVISORS LLC | 4,261 | 65,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
