| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Omega Fund Management, LLC | 2,600,410 | 36,172,000 | 14.63% | ||
| 2 | FMR LLC | 2,114,992 | 29,420,000 | 11.90% | ||
| 3 | BAUPOST GROUP LLC/MA | 2,044,498 | 28,439,000 | 11.51% | ||
| 4 | Abingworth LLP | 1,301,413 | 18,103,000 | 7.32% | ||
| 5 | Broadfin Capital, LLC | 803,332 | 11,174,000 | 4.52% | ||
| 6 | Tekla Capital Management LLC | 762,581 | 10,608,000 | 4.29% | ||
| 7 | BVF INC/IL | 575,000 | 7,998,000 | 3.24% | ||
| 8 | Aisling Capital LLC | 482,680 | 6,714,000 | 2.72% | ||
| 9 | GENERAL AMERICAN INVESTORS CO INC | 477,076 | 6,636,000 | 2.68% | ||
| 10 | Fortress Investment Group LLC | 433,804 | 6,034,000 | 2.44% | ||
| 11 | VANGUARD GROUP INC | 427,928 | 5,953,000 | 2.41% | ||
| 12 | Rock Springs Capital Management LP | 418,500 | 5,821,000 | 2.36% | ||
| 13 | BlackRock Fund Advisors | 373,419 | 5,194,000 | 2.10% | ||
| 14 | BROWN BROTHERS HARRIMAN & CO | 367,902 | 5,118,000 | 2.07% | ||
| 15 | Granahan Investment Management, LLC | 351,200 | 4,885,000 | 1.98% | ||
| 16 | Numeric Investors LLC | 311,655 | 4,335,000 | 1.75% | ||
| 17 | SABBY MANAGEMENT, LLC | 305,964 | 4,256,000 | 1.72% | ||
| 18 | Roumell Asset Management, LLC | 290,136 | 4,036,000 | 1.63% | ||
| 19 | Lombard Odier Asset Management (USA) Corp | 200,000 | 2,782,000 | 1.13% | ||
| 20 | NORTHERN TRUST CORP | 172,979 | 2,406,000 | 0.97% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 171,229 | 2,382,000 | 0.96% | ||
| 22 | STATE STREET CORP | 160,691 | 2,235,000 | 0.90% | ||
| 23 | Opaleye Management Inc. | 146,700 | 2,041,000 | 0.83% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 141,176 | 1,964,000 | 0.79% | ||
| 25 | SPHERA FUNDS MANAGEMENT LTD. | 140,000 | 1,947,000 | 0.79% | ||
| 26 | SENZAR ASSET MANAGEMENT, LLC | 134,219 | 1,866,986 | 0.76% | ||
| 27 | BARCLAYS PLC | 105,000 | 1,461,000 | 0.59% | Call | |
| 28 | RENAISSANCE TECHNOLOGIES LLC | 102,264 | 1,422,000 | 0.58% | ||
| 29 | Point72 Asset Management, L.P. | 100,000 | 1,391,000 | 0.56% | ||
| 30 | DEERFIELD MANAGEMENT COMPANY, L.P. | 100,000 | 1,391,000 | 0.56% | ||
| 31 | MONASHEE INVESTMENT MANAGEMENT LLC | 100,000 | 1,391,000 | 0.56% | PRN | |
| 32 | DEUTSCHE BANK AG\ | 95,180 | 1,323,000 | 0.54% | ||
| 33 | HIGHLAND CAPITAL MANAGEMENT LP | 75,000 | 1,044,000 | 0.42% | ||
| 34 | GOLDMAN SACHS GROUP INC | 71,334 | 992,000 | 0.40% | ||
| 35 | NEA Management Company, LLC | 66,245 | 921,000 | 0.37% | ||
| 36 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 65,660 | 913,000 | 0.37% | ||
| 37 | TURNER INVESTMENTS LLC | 63,480 | 883,000 | 0.36% | ||
| 38 | TUDOR INVESTMENT CORP ET AL | 62,500 | 869,000 | 0.35% | ||
| 39 | Polar Capital LLP | 59,230 | 824,000 | 0.33% | ||
| 40 | BlackRock Investment Management, LLC | 54,133 | 753,000 | 0.30% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 53,811 | 748,000 | 0.30% | ||
| 42 | Omega Advisors Inc. | 50,000 | 696,000 | 0.28% | ||
| 43 | BARCLAYS PLC | 50,000 | 696,000 | 0.28% | Put | |
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 48,462 | 674,000 | 0.27% | ||
| 45 | Granite Investment Partners, LLC | 47,776 | 665,000 | 0.27% | ||
| 46 | Bank of New York Mellon Corp | 45,140 | 628,000 | 0.25% | ||
| 47 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 40,000 | 556,000 | 0.22% | ||
| 48 | Candriam S.C.A. | 40,000 | 556,000 | 0.22% | ||
| 49 | Opus Point Partners Management, LLC | 37,665 | 524,000 | 0.21% | ||
| 50 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,222 | 420,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
