| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Omega Fund Management, LLC | 2,600,410 | 40,046,000 | 14.11% | ||
| 2 | FMR LLC | 2,115,292 | 32,575,000 | 11.48% | ||
| 3 | BAUPOST GROUP LLC/MA | 2,044,498 | 31,485,000 | 11.09% | ||
| 4 | Abingworth LLP | 1,301,413 | 19,977,000 | 7.04% | ||
| 5 | BlackRock Fund Advisors | 901,143 | 13,878,000 | 4.89% | ||
| 6 | Broadfin Capital, LLC | 786,134 | 12,106,000 | 4.27% | ||
| 7 | Tekla Capital Management LLC | 762,581 | 11,744,000 | 4.14% | ||
| 8 | VANGUARD GROUP INC | 661,179 | 10,182,000 | 3.59% | ||
| 9 | Rock Springs Capital Management LP | 525,500 | 8,093,000 | 2.85% | ||
| 10 | INTERWEST VENTURE MANAGEMENT CO | 512,366 | 7,890,000 | 2.78% | ||
| 11 | Aisling Capital LLC | 482,680 | 7,433,000 | 2.62% | ||
| 12 | Granahan Investment Management, LLC | 455,230 | 7,011,000 | 2.47% | ||
| 13 | Fortress Investment Group LLC | 433,804 | 6,680,000 | 2.35% | ||
| 14 | BROWN BROTHERS HARRIMAN & CO | 367,902 | 5,666,000 | 2.00% | ||
| 15 | Roumell Asset Management, LLC | 312,475 | 4,812,000 | 1.70% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 312,491 | 4,812,000 | 1.70% | ||
| 17 | GENERAL AMERICAN INVESTORS CO INC | 263,176 | 4,053,000 | 1.43% | ||
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 250,300 | 3,855,000 | 1.36% | ||
| 19 | NORTHERN TRUST CORP | 245,394 | 3,780,000 | 1.33% | ||
| 20 | STATE STREET CORP | 238,092 | 3,668,000 | 1.29% | ||
| 21 | Boston Partners | 156,858 | 2,416,000 | 0.85% | ||
| 22 | SPHERA FUNDS MANAGEMENT LTD. | 140,000 | 2,156,000 | 0.76% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 134,570 | 2,072,000 | 0.73% | ||
| 24 | DEUTSCHE BANK AG\ | 127,122 | 1,955,000 | 0.69% | ||
| 25 | SENZAR ASSET MANAGEMENT, LLC | 124,519 | 1,918,000 | 0.68% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 110,264 | 1,698,000 | 0.60% | ||
| 27 | SABBY MANAGEMENT, LLC | 110,000 | 1,694,000 | 0.60% | ||
| 28 | DEERFIELD MANAGEMENT COMPANY, L.P. | 100,000 | 1,540,000 | 0.54% | ||
| 29 | NEXTHERA CAPITAL LP | 100,000 | 1,540,000 | 0.54% | ||
| 30 | NORGES BANK | 96,500 | 1,486,000 | 0.52% | ||
| 31 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 92,660 | 1,427,000 | 0.50% | ||
| 32 | Point72 Asset Management, L.P. | 88,986 | 1,370,000 | 0.48% | ||
| 33 | Opus Point Partners Management, LLC | 80,000 | 1,232,000 | 0.43% | ||
| 34 | BlackRock Investment Management, LLC | 73,378 | 1,130,000 | 0.40% | ||
| 35 | Granite Investment Partners, LLC | 71,577 | 1,102,000 | 0.39% | ||
| 36 | Bank of New York Mellon Corp | 71,540 | 1,101,000 | 0.39% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 67,232 | 1,035,000 | 0.36% | ||
| 38 | NEA Management Company, LLC | 66,245 | 1,020,000 | 0.36% | ||
| 39 | TURNER INVESTMENTS LLC | 62,210 | 958,000 | 0.34% | ||
| 40 | MORGAN STANLEY | 59,450 | 916,000 | 0.32% | ||
| 41 | GOLDMAN SACHS GROUP INC | 54,595 | 841,000 | 0.30% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 47,237 | 727,000 | 0.26% | ||
| 43 | DLD ASSET MANAGEMENT, LP | 46,000 | 708,000 | 0.25% | Put | |
| 44 | ESSEX INVESTMENT MANAGEMENT CO LLC | 44,487 | 685,000 | 0.24% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,722 | 581,000 | 0.20% | ||
| 46 | SECOR Capital Advisors, LP | 36,685 | 565,000 | 0.20% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 30,322 | 467,000 | 0.16% | ||
| 48 | LPL Financial LLC | 29,450 | 459,000 | 0.16% | ||
| 49 | STONERIDGE INVESTMENT PARTNERS LLC | 28,110 | 433,000 | 0.15% | ||
| 50 | SHEPHERD KAPLAN KROCHUK, LLC | 27,339 | 421,000 | 0.15% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
