| 1 |
FMR LLC |
2,641,292 |
50,105,000 |
19.33% |
|
|
| 2 |
Omega Fund Management, LLC |
2,138,872 |
40,574,000 |
15.65% |
|
|
| 3 |
BAUPOST GROUP LLC/MA |
1,544,498 |
29,299,000 |
11.30% |
|
|
| 4 |
Abingworth LLP |
1,301,413 |
24,688,000 |
9.52% |
|
|
| 5 |
Tekla Capital Management LLC |
762,581 |
14,466,000 |
5.58% |
|
|
| 6 |
Aisling Capital LLC |
682,680 |
12,950,000 |
4.99% |
|
|
| 7 |
Broadfin Capital, LLC |
530,283 |
10,059,000 |
3.88% |
|
|
| 8 |
BROWN BROTHERS HARRIMAN & CO |
367,902 |
6,979,000 |
2.69% |
|
|
| 9 |
GREAT POINT PARTNERS LLC |
355,459 |
6,743,000 |
2.60% |
|
|
| 10 |
VANGUARD GROUP INC |
351,266 |
6,664,000 |
2.57% |
|
|
| 11 |
BlackRock Fund Advisors |
331,758 |
6,293,000 |
2.43% |
|
|
| 12 |
Granahan Investment Management, LLC |
329,019 |
6,241,000 |
2.41% |
|
|
| 13 |
GENERAL AMERICAN INVESTORS CO INC |
277,076 |
5,256,000 |
2.03% |
|
|
| 14 |
JPMORGAN CHASE & CO |
216,902 |
4,115,000 |
1.59% |
|
|
| 15 |
Roumell Asset Management, LLC |
199,555 |
3,786,000 |
1.46% |
|
|
| 16 |
STATE STREET CORP |
145,605 |
2,765,000 |
1.07% |
|
|
| 17 |
Lombard Odier Asset Management (USA) Corp |
141,367 |
2,682,000 |
1.03% |
|
|
| 18 |
NORTHERN TRUST CORP |
134,678 |
2,555,000 |
0.99% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
130,961 |
2,484,000 |
0.96% |
|
|
| 20 |
NEA Management Company, LLC |
125,004 |
2,371,000 |
0.91% |
|
|
| 21 |
SABBY MANAGEMENT, LLC |
122,613 |
2,326,000 |
0.90% |
|
|
| 22 |
Omega Advisors Inc. |
118,600 |
2,250,000 |
0.87% |
|
|
| 23 |
RENAISSANCE TECHNOLOGIES LLC |
83,813 |
1,590,000 |
0.61% |
|
|
| 24 |
TURNER INVESTMENTS LLC |
61,430 |
1,165,000 |
0.45% |
|
|
| 25 |
Opus Point Partners Management, LLC |
60,000 |
1,138,000 |
0.44% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
48,654 |
922,000 |
0.36% |
|
|
| 27 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
42,660 |
809,000 |
0.31% |
|
|
| 28 |
BlackRock Investment Management, LLC |
41,787 |
793,000 |
0.31% |
|
|
| 29 |
Bank of New York Mellon Corp |
40,760 |
773,000 |
0.30% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
40,658 |
771,000 |
0.30% |
|
|
| 31 |
Rock Springs Capital Management LP |
30,827 |
585,000 |
0.23% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
28,748 |
543,000 |
0.21% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
22,549 |
428,000 |
0.17% |
|
|
| 34 |
NORGES BANK |
21,313 |
404,000 |
0.16% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
17,609 |
334,000 |
0.13% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
17,408 |
331,000 |
0.13% |
|
|
| 37 |
VIRTUS ETF ADVISERS LLC |
15,819 |
300,000 |
0.12% |
|
|
| 38 |
TEACHER RETIREMENT SYSTEM OF TEXAS |
15,162 |
288,000 |
0.11% |
|
|
| 39 |
ARDSLEY ADVISORY PARTNERS LP |
15,000 |
285,000 |
0.11% |
|
|
| 40 |
RHUMBLINE ADVISERS |
12,217 |
232,000 |
0.09% |
|
|
| 41 |
Swiss National Bank |
12,000 |
228,000 |
0.09% |
|
|
| 42 |
NEW YORK STATE COMMON RETIREMENT FUND |
11,700 |
222,000 |
0.09% |
|
|
| 43 |
APPLETON PARTNERS INC/MA |
10,109 |
192,000 |
0.07% |
|
|
| 44 |
Weiss Multi-Strategy Advisers LLC |
10,000 |
190,000 |
0.07% |
|
|
| 45 |
METROPOLITAN LIFE INSURANCE CO/NY |
9,202 |
175,000 |
0.07% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
8,655 |
164,000 |
0.06% |
|
|
| 47 |
Nationwide Fund Advisors |
7,802 |
148,000 |
0.06% |
|
|
| 48 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,141 |
135,000 |
0.05% |
|
|
| 49 |
INTEGRATED WEALTH MANAGEMENT |
4,500 |
85,000 |
0.03% |
|
|
| 50 |
BLACKROCK ADVISORS LLC |
3,899 |
74,000 |
0.03% |
|
|
